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Terminating B cell receptor signaling

Mohammad, Dara K ; Nore, Beston F ; Smith, C. I. Edvard

Oncotarget, 2017, Vol.8(66), p.109857-109858 [Peer Reviewed Journal]

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β2‐microglobulin normalization within 6 months of ibrutinib‐based treatment is associated with superior progression‐free survival in patients with chronic lymphocytic leukemia

Thompson, Philip A. ; O' Brien, Susan M. ; Xiao, Lianchun ; Wang, Xuemei ; Burger, Jan A. ; Jain, Nitin ; Ferrajoli, Alessandra ; Estrov, Zeev ; Keating, Michael J. ; Wierda, William G.

Cancer, 15 February 2016, Vol.122(4), pp.565-573 [Peer Reviewed Journal]

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Bruton tyrosine kinase mediates TLR9-dependent human dendritic cell activation

Lougaris, Vassilios ; Baronio, Manuela ; Vitali, Massimiliano ; Tampella, Giacomo ; Cattalini, Marco ; Tassone, Laura ; Soresina, Annarosa ; Badolato, Raffaele ; Plebani, Alessandro

The Journal of Allergy and Clinical Immunology, June 2014, Vol.133(6), pp.1644-1650.e4 [Peer Reviewed Journal]

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Optimization of permeability in a series of pyrrolotriazine inhibitors of IRAK4

Degorce, Sébastien L ; Anjum, Rana ; Dillman, Keith S ; Drew, Lisa ; Groombridge, Sam D ; Halsall, Christopher T ; Lenz, Eva M ; Lindsay, Nicola A ; Mayo, Michele F ; Pink, Jennifer H ; Robb, Graeme R ; Scott, James S ; Stokes, Stephen ; Xue, Yafeng

Bioorganic & Medicinal Chemistry, 15 February 2018, Vol.26(4), pp.913-924 [Peer Reviewed Journal]

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Design and synthesis of phosphoryl-substituted diphenylpyrimidines (Pho-DPPYs) as potent Bruton’s tyrosine kinase (BTK) inhibitors: Targeted treatment of B lymphoblastic leukemia cell lines

Ge, Yang ; Yang, Haijun ; Wang, Changyuan ; Meng, Qiang ; Li, Lei ; Sun, Huijun ; Zhen, Yuhong ; Liu, Kexin ; Li, Yanxia ; Ma, Xiaodong

Bioorganic & Medicinal Chemistry, 15 January 2017, Vol.25(2), pp.765-772 [Peer Reviewed Journal]

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Myc enhances B cell receptor signaling in precancerous B cells and confers resistance to Btk inhibition

Moyo, Tamara K ; Wilson, Christopher S ; Moore, Daniel J ; Eischen, Christine M

Oncogene, 2017, Vol.36(32), p.4653-4661 [Peer Reviewed Journal]

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Discovery of novel Bruton’s tyrosine kinase (BTK) inhibitors bearing a pyrrolo[2,3-d]pyrimidine scaffold

Zhao, Xinge ; Huang, Wei ; Wang, Yazhou ; Xin, Minhang ; Jin, Qiu ; Cai, Jianfeng ; Tang, Feng ; Zhao, Yong ; Xiang, Hua

Bioorganic & Medicinal Chemistry, 15 February 2015, Vol.23(4), pp.891-901 [Peer Reviewed Journal]

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Design, synthesis and evaluation of novel 5-phenylpyridin-2(1H)-one derivatives as potent reversible Bruton’s tyrosine kinase inhibitors

Zhao, Xinge ; Xin, Minhang ; Huang, Wei ; Ren, Yanliang ; Jin, Qiu ; Tang, Feng ; Jiang, Hailong ; Wang, Yazhou ; Yang, Jie ; Mo, Shifu ; Xiang, Hua

Bioorganic & Medicinal Chemistry, 15 January 2015, Vol.23(2), pp.348-364 [Peer Reviewed Journal]

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Pyrrolo[2,3-b]pyridine derivatives as potent Bruton’s tyrosine kinase inhibitors

Zhao, Xinge ; Huang, Wei ; Wang, Yazhou ; Xin, Minhang ; Jin, Qiu ; Cai, Jianfeng ; Tang, Feng ; Zhao, Yong ; Xiang, Hua

Bioorganic & Medicinal Chemistry, 01 August 2015, Vol.23(15), pp.4344-4353 [Peer Reviewed Journal]

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First-in-human phase 1 study of the BTK inhibitor GDC-0853 in relapsed or refractory B-cell NHL and CLL

Byrd, John C ; Smith, Stephen ; Wagner-Johnston, Nina ; Sharman, Jeff ; Chen, Andy I ; Advani, Ranjana ; Augustson, Bradley ; Marlton, Paula ; Renee Commerford, S ; Okrah, Kwame ; Liu, Lichuan ; Murray, Elaine ; Penuel, Elicia ; Ward, Ashley F ; Flinn, Ian W

Oncotarget, 2018, Vol.9(16), p.13023-13035 [Peer Reviewed Journal]

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Novel small molecule therapeutics in rheumatoid arthritis

Kelly, Victoria ; Genovese, Mark

Rheumatology, 2013, Vol. 52(7), pp.1155-1162 [Peer Reviewed Journal]

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The mTOR kinase inhibitor everolimus synergistically enhances the anti‐tumor effect of the Bruton's tyrosine kinase (BTK) inhibitor PLS‐123 on Mantle cell lymphoma

Li, Jiao ; Wang, Xiaogan ; Xie, Yan ; Ying, Zhitao ; Liu, Weiping ; Ping, Lingyan ; Zhang, Chen ; Pan, Zhengying ; Ding, Ning ; Song, Yuqin ; Zhu, Jun

International Journal of Cancer, 01 January 2018, Vol.142(1), pp.202-213 [Peer Reviewed Journal]

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Design, synthesis and biological evaluation of novel 3-substituted pyrazolopyrimidine derivatives as potent Bruton’s tyrosine kinase (BTK) inhibitors

Zheng, Nan ; Pan, Jing ; Hao, Qun ; Li, Yingxia ; Zhou, Weicheng

Bioorganic & Medicinal Chemistry, 01 May 2018, Vol.26(8), pp.2165-2172 [Peer Reviewed Journal]

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Synthesis and biological evaluation of novel 7-substituted 3-(4-phenoxyphenyl)thieno[3,2-c]pyridin-4-amines as potent Bruton’s tyrosine kinase (BTK) inhibitors

Xin, Minhang ; Zhao, Xinge ; Huang, Wei ; Jin, Qiu ; Wu, Gang ; Wang, Yazhou ; Tang, Feng ; Xiang, Hua

Bioorganic & Medicinal Chemistry, 01 October 2015, Vol.23(19), pp.6250-6257 [Peer Reviewed Journal]

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Design and synthesis of benzofuro[3,2-b]pyridin-2(1H)-one derivatives as anti-leukemia agents by inhibiting Btk and PI3Kδ

Liu, Linyi ; Shi, Bingyu ; Li, Xinyu ; Wang, Xiangqian ; Lu, Xiang ; Cai, Xuerong ; Huang, Ali ; Luo, Guoshun ; You, Qidong ; Xiang, Hua

Bioorganic & Medicinal Chemistry, 15 August 2018, Vol.26(15), pp.4537-4543 [Peer Reviewed Journal]

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Discovery of thieno[3,2-c]pyridin-4-amines as novel Bruton’s tyrosine kinase (BTK) inhibitors

Zhao, Xinge ; Xin, Minhang ; Wang, Yazhou ; Huang, Wei ; Jin, Qiu ; Tang, Feng ; Wu, Gang ; Zhao, Yong ; Xiang, Hua

Bioorganic & Medicinal Chemistry, 01 September 2015, Vol.23(17), pp.6059-6068 [Peer Reviewed Journal]

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17
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Targeting Btk with ibrutinib inhibit gastric carcinoma cells growth

Wang, Jin Dao ; Chen, Xiao Ying ; Ji, Ke Wei ; Tao, Feng

American journal of translational research, 2016, Vol.8(7), pp.3003-12 [Peer Reviewed Journal]

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18
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Btk-dependent epithelial cell rearrangements contribute to the invagination of nearby tubular structures in the posterior spiracles of Drosophila

Tsikala, Georgia ; Karagogeos, Domna ; Strigini, Maura

Developmental Biology, 01 December 2014, Vol.396(1), pp.42-56 [Peer Reviewed Journal]

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19
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Ibrutinib versus temsirolimus in patients with relapsed or refractory mantle-cell lymphoma: an international, randomised, open-label, phase study

Dreyling, Martin ; Jurczak, Wojciech ; Jerkeman, Mats ; Silva, Rodrigo Santucci ; Rusconi, Chiara ; Trneny, Marek ; Offner, Fritz ; Caballero, Dolores ; Joao, Cristina ; Witzens - Harig, Mathias ; Hess, Georg ; Bence - Bruckler, Isabelle ; Cho, Seok - Goo ; Bothos, John ; Goldberg, Jenna D ; Enny, Christopher ; Traina, Shana ; Balasubramanian, Sriram ; Bandyopadhyay, Nibedita ; Sun, Steven ; Vermeulen, Jessica ; Rizo, Aleksandra ; Rule, Simon

LANCET, 2016 [Peer Reviewed Journal]

2016

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20
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Development of the Bruton's tyrosine kinase inhibitor ibrutinib for B cell malignancies

Gayko, Urte ; Fung, Mann ; Clow, Fong ; Sun, Steven ; Faust, Elizabeth ; Price, Samiyeh ; James, Danelle ; Doyle, Margaret ; Bari, Samina ; Zhuang, Sen Hong

Annals of the New York Academy of Sciences, November 2015, Vol.13581(1), pp.82-94 [Peer Reviewed Journal]

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21
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Control of nuclear-cytoplasmic shuttling of Ankrd54 by PKCδ

Samuels, Amy L ; Louw, Alison ; Zareie, Reza ; Ingley, Evan

World Journal of Biological Chemistry, 2017, Vol.8(3), p.163-174 [Peer Reviewed Journal]

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22
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MyD88 is involved in myeloid as well as lymphoid hematopoiesis independent of the presence of a pathogen

Fiedler, Katja ; Kokai, Enikö ; Bresch, Susanne ; Brunner, Cornelia

American journal of blood research, 2013, Vol.3(2), pp.124-40 [Peer Reviewed Journal]

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23
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Transcription factor PU.1 is involved in the progression of glioma

Xu, Yuanzhi ; Gu, Song ; Bi, Yunke ; Qi, Xiangqian ; Yan, Yujin ; Lou, Meiqing

Oncology Letters, 2018, Vol.15(3), pp.3753-3759 [Peer Reviewed Journal]

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24
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BTK blocks the inhibitory effects of MDM2 on p53 activity

Rada, Miran ; Althubiti, Mohammad ; Ekpenyong-Akiba, Akang E ; Lee, Koon-Guan ; Lam, Kong Peng ; Fedorova, Olga ; Barlev, Nickolai A ; Macip, Salvador

Oncotarget, 2017, Vol.8(63), p.106639-106647 [Peer Reviewed Journal]

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25
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Therapeutic potential of new B cell-targeted agents in the treatment of elderly and unfit patients with chronic lymphocytic leukemia

Rai, Kanti ; Rai, Kanti

Journal of Hematology & Oncology, 2015, Vol.8 [Peer Reviewed Journal]

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26
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The effect of Bruton's tyrosine kinase (BTK) inhibitors on collagen‐induced platelet aggregation, BTK, and tyrosine kinase expressed in hepatocellular carcinoma (TEC

Chen, Jun ; Kinoshita, Taisei ; Gururaja, Tarikere ; Sukbuntherng, Juthamas ; James, Danelle ; Lu, Daniel ; Whang, Jennifer ; Versele, Matthias ; Chang, Betty Y.

European Journal of Haematology, November 2018, Vol.101(5), pp.604-612 [Peer Reviewed Journal]

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27
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Ibrutinib repurposing: from B-cell malignancies to solid tumors

Massó-Vallés, Daniel ; Jauset, Toni ; Soucek, Laura

Oncoscience, 2016, Vol.3(5-6), pp.147-8 [Peer Reviewed Journal]

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28
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A Tec kinase BTK inhibitor ibrutinib promotes maturation and activation of dendritic cells

Natarajan, Gayathri ; Oghumu, Steve ; Terrazas, Cesar ; Varikuti, Sanjay ; Byrd, John C ; Satoskar, Abhay R

OncoImmunology, 02 June 2016, Vol.5(6)

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29
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Separate checkpoints regulate splenic plasma cell accumulation and IgG autoantibody production in Lyn‐deficient mice

Gutierrez, Toni ; Halcomb, Kristina E. ; Coughran, Alanna J. ; Li, Quan‐Zhen ; Satterthwaite, Anne B.

European Journal of Immunology, July 2010, Vol.40(7), pp.1897-1905 [Peer Reviewed Journal]

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30
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Bruton's Tyrosine Kinase mediates platelet receptor-induced generation of microparticles: A potential mechanism for amplification of inflammatory responses in rheumatoid arthritis synovial joints

Hsu, Jonathan ; Gu, Yajuan ; Tan, Seng-Lai ; Narula, Satwant ; Demartino, Julie A ; Liao, Cheng

Immunology Letters, February 2013, Vol.150(1-2), pp.97-104 [Peer Reviewed Journal]

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31
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Evaluation of 230 patients with relapsed/refractory deletion 17p chronic lymphocytic leukaemia treated with ibrutinib from 3 clinical trials

Jones, Jeffrey ; Mato, Anthony ; Coutre, Steven ; Byrd, John C. ; Furman, Richard R. ; Hillmen, Peter ; Osterborg, Anders ; Tam, Constantine ; Stilgenbauer, Stephan ; Wierda, William G. ; Heerema, Nyla A. ; Eckert, Karl ; Clow, Fong ; Zhou, Cathy ; Chu, Alvina D. ; James, Danelle F. ; O' Brien, Susan M.

British Journal of Haematology, August 2018, Vol.182(4), pp.504-512 [Peer Reviewed Journal]

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32
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Purine derivatives as potent Bruton’s tyrosine kinase (BTK) inhibitors for autoimmune diseases

Shi, Qing ; Tebben, Andrew ; Dyckman, Alaric J ; Li, Hedy ; Liu, Chunjian ; Lin, James ; Spergel, Steve ; Burke, James R ; Mcintyre, Kim W ; Olini, Gilbert C ; Strnad, Joann ; Surti, Neha ; Muckelbauer, Jodi K ; Chang, Chiehying ; An, Yongmi ; Cheng, Lin ; Ruan, Qian ; Leftheris, Katerina ; Carter, Percy H ; Tino, Joseph

Bioorganic & Medicinal Chemistry Letters, 01 May 2014, Vol.24(9), pp.2206-2211 [Peer Reviewed Journal]

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33
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High expression of Bruton's tyrosine kinase (BTK) is required for EGFR-induced NF-κB activation and predicts poor prognosis in human glioma

Yue, Chenglong ; Niu, Mingshan ; Shan, Qian Qian ; Zhou, Ting ; Tu, Yiming ; Xie, Peng ; Hua, Lei ; Yu, Rutong ; Liu, Xuejiao

Journal of experimental & clinical cancer research : CR, 25 September 2017, Vol.36(1), pp.132 [Peer Reviewed Journal]

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34
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Ibrutinib inhibits SDF1/CXCR4 mediated migration in AML

Zaitseva, Lyubov ; Murray, Megan Y ; Shafat, Manar S ; Lawes, Matthew J ; Macewan, David J ; Bowles, Kristian M ; Rushworth, Stuart A

Oncotarget, 2014, Vol.5(20), p.9930-9938 [Peer Reviewed Journal]

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35
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Clinical and mutational features of X-linked agammaglobulinemia in Mexico

García-García, E ; Staines-Boone, A.T ; Vargas-Hernández, A ; González-Serrano, M.E ; Carrillo-Tapia, E ; Mogica-Martínez, D ; Berrón-Ruíz, L ; Segura-Mendez, N.H ; Espinosa-Rosales, F.J ; Yamazaki-Nakashimada, M.A ; Santos-Argumedo, L ; López-Herrera, G

Clinical Immunology, April 2016, Vol.165, pp.38-44 [Peer Reviewed Journal]

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36
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Influence of Barrier Width on Spin-Polarisation Measured by Point Contact Andreev Reflection

Wójcik, P. ; Naylor, A. ; Wołoszyn, M. ; Hickey, B. ; Spisak, B. ; Adamowski, J.

Journal of Superconductivity and Novel Magnetism, 2011, Vol.24(1), pp.939-943 [Peer Reviewed Journal]

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37
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Identification of highly potent BTK and JAK3 dual inhibitors with improved activity for the treatment of B-cell lymphoma

Ge, Yang ; Wang, Changyuan ; Song, Shijie ; Huang, Jiaxin ; Liu, Zhihao ; Li, Yongming ; Meng, Qiang ; Zhang, Jianbin ; Yao, Jihong ; Liu, Kexin ; Ma, Xiaodong ; Sun, Xiuli

European Journal of Medicinal Chemistry, 01 January 2018, Vol.143, pp.1847-1857 [Peer Reviewed Journal]

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