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11 Results  for Everything (Includes Articles)

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Synthesis of novel anti-inflammatory steroidal macrocycles using ring closing metathesis reaction

Biju, Purakkattle ; Bitar, Rema ; Lim, Yeon-Hee ; Wang, Ying ; Berlin, Michael ; Aslanian, Robert ; Mccormick, Kevin

Tetrahedron Letters, 21 January 2015, Vol.56(4), pp.636-638 [Peer Reviewed Journal]

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A new synthesis of 3,4-disubstituted 1,2,5-thiadiazoles

Biju, Purakkattle ; Yu, Younong

Tetrahedron Letters, 2007, Vol.48(30), pp.5279-5282 [Peer Reviewed Journal]

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Steroidal C-21 heteroaryl thioethers (Part 2): Discovery of orally bioavailable selective glucocorticoid receptor modulators (dissociated steroids)

Biju, Purakkattle ; Mccormick, Kevin ; Aslanian, Robert ; Berlin, Michael ; Solomon, Daniel ; Wang, Hongwu ; Lee, Yoon Joo ; Bitar, Rema ; Prelusky, Daniel ; Mcleod, Robbie ; Jia, Yanlin ; Fernandez, Xiomora ; Eckel, Stephen ; House, Aileen ; Lieber, Gissela ; Jimenez, Johanna ; Kelly, George ; Chapman, Richard ; Phillips, Jonathan ; Anthes, John

Bioorganic & Medicinal Chemistry Letters, 15 January 2012, Vol.22(2), pp.1086-1090 [Peer Reviewed Journal]

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Steroidal C-21 mercapto derivatives as dissociated steroids: Discovery of an inhaled dissociated steroid

Biju, Purakkattle ; Mccormick, Kevin ; Aslanian, Robert ; Berlin, Michael ; Solomon, Daniel ; Chapman, Richard ; Mcleod, Robbie ; Prelusky, Daniel ; Eckel, Stephen ; Kelly, George ; Natiello, Michelle ; House, Aileen ; Fernandez, Xiomara ; Bitar, Rema ; Phillips, Jonathan ; Anthes, John

Bioorganic & Medicinal Chemistry Letters, 2011, Vol.21(21), pp.6343-6347 [Peer Reviewed Journal]

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Steroidal C-21 heteroaryl thioethers. Part 3: Pregn-4-eno-[3,2-c]pyrazole fused A ring modified steroids as selective glucocorticoid receptor modulators (dissociated steroids)

Biju, Purakkattle ; Wang, Hongwu ; Anthes, John ; Mccormick, Kevin ; Aslanian, Robert ; Berlin, Michael ; Bitar, Rema ; Lim, Yeon-Hee ; Lee, Yoon Joo ; Prelusky, Daniel ; Mcleod, Robbie ; Jia, Yanlin ; Fernandez, Xiomora ; Lieber, Gissela ; Jimenez, Johanna ; Eckel, Steve ; House, Aileen ; Chapman, Richard ; Phillips, Jonathan

Bioorganic & Medicinal Chemistry Letters, 01 May 2012, Vol.22(9), pp.3291-3295 [Peer Reviewed Journal]

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Discovery of MK-8318, a Potent and Selective CRTh2 Receptor Antagonist for the Treatment of Asthma

Huang, Xianhai ; Brubaker, Jason ; Zhou, Wei ; Biju, Purakkattle J ; Xiao, Li ; Shao, Ning ; Huang, Ying ; Dong, Li ; Liu, Zhidan ; Bitar, Rema ; Buevich, Alexei ; Jung, Joon ; Peterson, Scott L ; Butcher, John W ; Close, Joshua ; Martinez, Michelle ; Maccoss, Rachel N ; Zhang, Hongjun ; Crawford, Scott ; Mccormick

ACS medicinal chemistry letters, 12 July 2018, Vol.9(7), pp.679-684 [Peer Reviewed Journal]

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Discovery of 2-hydroxy-N,N-dimethyl-3-{2-(R)-1-(5- methylfuran-2-yl)propylamino-3,4-dioxocyclobut-1-enylamino}benzamide (SCH 527123): a potent, orally bioavailable CXCR2/CXCR1 receptor antagonist

Dwyer, Michael P ; Yu, Younong ; Chao, Jianping ; Aki, Cynthia ; Chao, Jianhua ; Biju, Purakkattle ; Girijavallabhan, Viyyoor ; Rindgen, Diane ; Bond, Richard ; Mayer-Ezel, Rosemary ; Jakway, James ; Hipkin, R William ; Fossetta, James ; Gonsiorek, Waldemar ; Bian, Hong ; Fan, Xuedong ; Terminelli, Carol ; Fine, Jay ; Lundell, Daniel ; Merritt

Journal of medicinal chemistry, 28 December 2006, Vol.49(26), pp.7603-6 [Peer Reviewed Journal]

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Fluoroalkyl α side chain containing 3,4-diamino-cyclobutenediones as potent and orally bioavailable CXCR2–CXCR1 dual antagonists

Biju, Purakkattle ; Taveras, Arthur G ; Dwyer, Michael P ; Yu, Younong ; Chao, Jianhua ; Hipkin, R. William ; Fan, Xuedong ; Rindgen, Diane ; Fine, Jay ; Lundell, Daniel

Bioorganic & Medicinal Chemistry Letters, 2009, Vol.19(5), pp.1431-1433 [Peer Reviewed Journal]

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3,4-Diamino-1,2,5-thiadiazole as potent and selective CXCR2 antagonists

Biju, Purakkattle ; Taveras, Arthur G ; Yu, Younong ; Zheng, Junying ; Hipkin, R. William ; Fossetta, James ; Fan, Xuedong ; Fine, Jay ; Lundell, Daniel

Bioorganic & Medicinal Chemistry Letters, 2009, Vol.19(5), pp.1434-1437 [Peer Reviewed Journal]

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Diaminocyclobutenediones as potent and orally bioavailable CXCR2 receptor antagonists: SAR in the phenolic amide region

Aki, Cynthia ; Chao, Jianping ; Ferreira, Johan A ; Dwyer, Michael P ; Yu, Younong ; Chao, Jianhua ; Merritt, Robert J ; Lai, Gaifa ; Wu, Minglang ; Hipkin, R. William ; Fan, Xuedong ; Gonsiorek, Waldemar ; Fosseta, James ; Rindgen, Diane ; Fine, Jay ; Lundell, Daniel ; Taveras, Arthur G ; Biju, Purakkattle

Bioorganic & Medicinal Chemistry Letters, 01 August 2009, Vol.19(15), pp.4446-4449 [Peer Reviewed Journal]

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3,4-Diamino-2,5-thiadiazole-1-oxides as potent CXCR2/CXCR1 antagonists

Biju, Purakkattle ; Taveras, Arthur ; Yu, Younong ; Zheng, Junying ; Chao, Jianhua ; Rindgen, Diane ; Jakway, James ; Hipkin, R. William ; Fossetta, James ; Fan, Xuedong ; Fine, Jay ; Qiu, Hongchen ; Merritt, J. Robert ; Baldwin, John J

Bioorganic & Medicinal Chemistry Letters, 2008, Vol.18(1), pp.228-231 [Peer Reviewed Journal]

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