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1
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Alteration of lymphocyte trafficking by sphingosine-1-phosphate receptor agonists

Mandala, Suzanne ; Hajdu, Richard ; Bergstrom, James ; Quackenbush, Elizabeth ; Xie, Jenny ; Milligan, James ; Thornton, Rosemary ; Shei, Gan-Ju ; Card, Deborah ; Keohane, Carolann ; Rosenbach, Mark ; Hale, Jeffrey ; Lynch, Christopher L ; Rupprecht, Kathleen ; Parsons, William ; Rosen, Hugh

Science (New York, N.Y.), 12 April 2002, Vol.296(5566), pp.346-9 [Peer Reviewed Journal]

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2
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Milk-substitutes comparable to rat's milk; their preparation, composition and impact on development and metabolism in the artificially reared rat

Auestad, Nancy ; Korsak, Rose A ; Bergstrom, James D ; Edmond, John

British Journal of Nutrition, 1989, Vol.61(3), pp.495-518 [Peer Reviewed Journal]

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3
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A radiochemical assay for acetoacetyl-CoA synthetase

Bergstrom, James D ; Edmond, John

Analytical Biochemistry, 1985, Vol.149(2), pp.358-364 [Peer Reviewed Journal]

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4
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Color imaging of Mars by the High Resolution Imaging Science Experiment (HiRISE)

Delamere, W. Alan ; Tornabene, Livio L ; Mcewen, Alfred S ; Becker, Kris ; Bergstrom, James W ; Bridges, Nathan T ; Eliason, Eric M ; Gallagher, Dennis ; Herkenhoff, Kenneth E ; Keszthelyi, Laszlo ; Mattson, Sarah ; Mcarthur, Guy K ; Mellon, Michael T ; Milazzo, Moses ; Russell, Patrick S ; Thomas, Nicolas

Icarus, 2010, Vol.205(1), pp.38-52 [Peer Reviewed Journal]

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5
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A rational utilization of high-throughput screening affords selective, orally bioavailable 1-benzyl-3-carboxyazetidine sphingosine-1-phosphate-1 receptor agonists

Hale, Jeffrey J ; Lynch, Christopher L ; Neway, William ; Mills, Sander G ; Hajdu, Richard ; Keohane, Carol Ann ; Rosenbach, Mark J ; Milligan, James A ; Shei, Gan-Ju ; Parent, Stephen A ; Chrebet, Gary ; Bergstrom, James ; Card, Deborah ; Ferrer, Marc ; Hodder, Peter ; Strulovici, Berta ; Rosen, Hugh ; Mandala, Suzanne

Journal of medicinal chemistry, 30 December 2004, Vol.47(27), pp.6662-5 [Peer Reviewed Journal]

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Synthesis, stereochemical determination and biochemical characterization of the enantiomeric phosphate esters of the novel immunosuppressive agent FTY720

Hale, Jeffrey J ; Yan, Lin ; Neway, William E ; Hajdu, Richard ; Bergstrom, James D ; Milligan, James A ; Shei, Gan-Ju ; Chrebet, Gary L ; Thornton, Rosemary A ; Card, Deborah ; Rosenbach, Mark ; Hughrosen ; Mandala, Suzanne

Bioorganic & Medicinal Chemistry, 15 September 2004, Vol.12(18), pp.4803-4807 [Peer Reviewed Journal]

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7
Clavaric Acid and Steroidal Analogues as Ras- and FPP-Directed Inhibitors of Human Farnesyl-Protein Transferase
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Clavaric Acid and Steroidal Analogues as Ras- and FPP-Directed Inhibitors of Human Farnesyl-Protein Transferase

Lingham, Russell B. ; Silverman, Keith C. ; Jayasuriya, Hiranthi ; Kim, B. Moon ; Amo, Suzanne E. ; Wilson, Francine R. ; Rew, Deborah J. ; Schaber, Michael D. ; Bergstrom, James D. ; Koblan, Kenneth S. ; Graham, Samuel L. ; Kohl, Nancy E. ; Gibbs, Jackson B. ; Singh, Sheo B.

Journal of Medicinal Chemistry, 11/1998, Vol.41(23), pp.4492-4501 [Peer Reviewed Journal]

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8
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Laboratory calibration of the optical transient detector and the lightning imaging sensor

Koshak, William ; Stewart, Mike ; Christian, Hugh ; Bergstrom, James

Journal of Atmospheric and Oceanic Technology, Jul 2000, Vol.17(7), pp.905-915 [Peer Reviewed Journal]

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9
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Discovery of potent 3,5-diphenyl-1,2,4-oxadiazole sphingosine-1-phosphate-1 (S1P1) receptor agonists with exceptional selectivity against S1P2 and S1P3

Li, Zhen ; Chen, Weirong ; Hale, Jeffrey J ; Lynch, Christopher L ; Mills, Sander G ; Hajdu, Richard ; Keohane, Carol Ann ; Rosenbach, Mark J ; Milligan, James A ; Shei, Gan-Ju ; Chrebet, Gary ; Parent, Stephen A ; Bergstrom, James ; Card, Deborah ; Forrest, Michael ; Quackenbush, Elizabeth J ; Wickham, L Alexandra ; Vargas, Hugo ; Evans, Rose M ; Rosen

Journal of medicinal chemistry, 06 October 2005, Vol.48(20), pp.6169-73 [Peer Reviewed Journal]

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10
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Studies on carnitine palmitoyl transferase: The similar nature of CPT I (inner form) and CPT O (outer form)

Bergstrom, James D ; Reitz, Ronald C

Archives of Biochemistry and Biophysics, 1980, Vol.204(1), pp.71-79 [Peer Reviewed Journal]

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11
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Phytosphingosine 1-phosphate: a high affinity ligand for the S1P 4/Edg-6 receptor

Rios Candelore, Mari ; Wright, Michael J ; Tota, Laurie M ; Milligan, James ; Shei, Gan-Ju ; Bergstrom, James D ; Mandala, Suzanne M

Biochemical and Biophysical Research Communications, 2002, Vol.297(3), pp.600-606 [Peer Reviewed Journal]

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12
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3,4-Diesters of zaragozic acid A

Chiang, Yuan-Ching P ; Kurtz, Marc M ; Bergstrom, James D ; Berger, Gregory D

Bioorganic & Medicinal Chemistry Letters, 1995, Vol.5(15), pp.1643-1646 [Peer Reviewed Journal]

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13
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The isolation and structure elucidation of zaragozic acid C, a novel potent squalene synthase inhibitor

Dufresne, Claude ; Wilson, Kenneth E ; Zink, Deborah ; Smith, Jack ; Bergstrom, James D ; Kurtz, Marc ; Rew, Deborah ; Nallin, Mary ; Jenkins, Rosalind ; Bartizal, Ken ; Trainor, Charlotte ; Bills, Gerald ; Meinz, Maria ; Huang, Leeyuan ; Onishi, Janet ; Milligan, James ; Mojena, Marina ; Pelaez, Fernando

Tetrahedron, 1992, Vol.48(47), pp.10221-10226 [Peer Reviewed Journal]

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14
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Acetoacetyl-coenzyme A synthetase activity in rat liver cytosol: A regulated enzyme in lipogenesis

Bergstrom, James D ; Robbins, Kathy Ann ; Edmond, John

Biochemical and Biophysical Research Communications, 1982, Vol.106(3), pp.856-862 [Peer Reviewed Journal]

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15
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Massive Production of Farnesol-Derived Dicarboxylic Acids in Mice Treated with the Squalene Synthase Inhibitor Zaragozic Acid A

Vaidya, Sanskruti ; Bostedor, Richard ; Kurtz, Marc M ; Bergstrom, James D ; Bansal, Vinay S

Archives of Biochemistry and Biophysics, 01 July 1998, Vol.355(1), pp.84-92 [Peer Reviewed Journal]

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16
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Alendronate Is a Specific, Nanomolar Inhibitor of Farnesyl Diphosphate Synthase

Bergstrom, James D ; Bostedor, Richard G ; Masarachia, Patricia J ; Reszka, Alfred A ; Rodan, Gideon

Archives of Biochemistry and Biophysics, 01 January 2000, Vol.373(1), pp.231-241 [Peer Reviewed Journal]

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17
Novel Zaragozic Acids from Leptodontidium elatius
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Novel Zaragozic Acids from Leptodontidium elatius

Dufresne, Claude ; Jones, E. Tracy Turner ; Omstead, Mary Nallin ; Bergstrom, James D. ; Wilson, Kenneth E.

Journal of Natural Products, 01/1996, Vol.59(1), pp.52-54 [Peer Reviewed Journal]

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18
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SAR studies of 3-arylpropionic acids as potent and selective agonists of sphingosine-1-phosphate receptor-1 (S1P 1) with enhanced pharmacokinetic properties

Yan, Lin ; Huo, Pei ; Hale, Jeffrey J ; Mills, Sander G ; Hajdu, Richard ; Keohane, Carol A ; Rosenbach, Mark J ; Milligan, James A ; Shei, Gan-Ju ; Chrebet, Gary ; Bergstrom, James ; Card, Deborah ; Mandala, Suzanne M

Bioorganic & Medicinal Chemistry Letters, 2007, Vol.17(3), pp.828-831 [Peer Reviewed Journal]

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19
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Identification of Leu276 of the S1P1 receptor and Phe263 of the S1P3 receptor in interaction with receptor specific agonists by molecular modeling, site-directed mutagenesis, and affinity studies

Deng, Qiaolin ; Clemas, Joseph A ; Chrebet, Gary ; Fischer, Paul ; Hale, Jeffrey J ; Li, Zhen ; Mills, Sander G ; Bergstrom, James ; Mandala, Suzanne ; Mosley, Ralph ; Parent, Stephen A

Molecular pharmacology, March 2007, Vol.71(3), pp.724-35 [Peer Reviewed Journal]

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20
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The discovery of 3-(N-alkyl)aminopropylphosphonic acids as potent S1P receptor agonists

Hale, Jeffrey J ; Doherty, George ; Toth, Leslie ; Li, Zhen ; Mills, Sander G ; Hajdu, Richard ; Ann Keohane, Carol ; Rosenbach, Mark ; Milligan, James ; Shei, Gan-Ju ; Chrebet, Gary ; Bergstrom, James ; Card, Deborah ; Rosen, Hugh ; Mandala, Suzanne

Bioorganic & Medicinal Chemistry Letters, 2004, Vol.14(13), pp.3495-3499 [Peer Reviewed Journal]

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21
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The High Resolution Imaging Science Experiment (HiRISE) during MRO’s Primary Science Phase (PSP)

Mcewen, Alfred S ; Banks, Maria E ; Baugh, Nicole ; Becker, Kris ; Boyd, Aaron ; Bergstrom, James W ; Beyer, Ross A ; Bortolini, Edward ; Bridges, Nathan T ; Byrne, Shane ; Castalia, Bradford ; Chuang, Frank C ; Crumpler, Larry S ; Daubar, Ingrid ; Davatzes, Alix K ; Deardorff, Donald G ; Dejong, Alaina ; Alan Delamere, W ; Dobrea, Eldar Noe ; Dundas, Colin M

Icarus, 2010, Vol.205(1), pp.2-37 [Peer Reviewed Journal]

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22
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Design and synthesis of squalene synthase inhibitors - acylic mimics of the zaragazic acids

Kuo, C.H ; Robichaud, Albert J ; Rew, Deborah J ; Bergstrom, James D ; Berger, Gregory D

Bioorganic & Medicinal Chemistry Letters, 1994, Vol.4(13), pp.1591-1594 [Peer Reviewed Journal]

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23
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27 Hepatic responses to inhibition of HMG-CoA reductase: a comparison of atorvastatin and simvastatin

Bergstrom, James D ; Bostedor, Richard G ; Rew, Deborah J ; Giessler, Wayne M ; Wright, Samuel D ; Chao, Yu-Sheng

Atherosclerosis, 1997, Vol.130, pp.S8-S8 [Peer Reviewed Journal]

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24
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Characterization of purified guanine aminohydrolase

Bergstrom, James D ; Bieber, Allan L

Archives of Biochemistry and Biophysics, 1979, Vol.194(1), pp.107-116 [Peer Reviewed Journal]

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25
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2-Aryl(pyrrolidin-4-yl)acetic acids are potent agonists of sphingosine-1-phosphate (S1P) receptors

Yan, Lin ; Budhu, Richard ; Huo, Pei ; Lynch, Christopher L ; Hale, Jeffrey J ; Mills, Sander G ; Hajdu, Richard ; Keohane, Carol A ; Rosenbach, Mark J ; Milligan, James A ; Shei, Gan-Ju ; Chrebet, Gary ; Bergstrom, James ; Card, Deborah ; Mandala, Suzanne M

Bioorganic & Medicinal Chemistry Letters, 01 July 2006, Vol.16(13), pp.3564-3568 [Peer Reviewed Journal]

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26
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2,5-Disubstituted pyrrolidine carboxylates as potent, orally active sphingosine-1-phosphate (S1P) receptor agonists

Colandrea, Vincent J ; Legiec, Irene E ; Huo, Pei ; Yan, Lin ; Hale, Jeffrey J ; Mills, Sander G ; Bergstrom, James ; Card, Deborah ; Chebret, Gary ; Hajdu, Richard ; Keohane, Carol Ann ; Milligan, James A ; Rosenbach, Mark J ; Shei, Gan-Ju ; Mandala, Suzanne M

Bioorganic & Medicinal Chemistry Letters, 2006, Vol.16(11), pp.2905-2908 [Peer Reviewed Journal]

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27
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Discovery of 3-arylpropionic acids as potent agonists of sphingosine-1-phosphate receptor-1 (S1P 1) with high selectivity against all other known S1P receptor subtypes

Yan, Lin ; Huo, Pei ; Doherty, George ; Toth, Lesile ; Hale, Jeffrey J ; Mills, Sander G ; Hajdu, Richard ; Keohane, Carol A ; Rosenbach, Mark J ; Milligan, James A ; Shei, Gan-Ju ; Chrebet, Gary ; Bergstrom, James ; Card, Deborah ; Quackenbush, Elizabeth ; Wickham, Alexandra ; Mandala, Suzanne M

Bioorganic & Medicinal Chemistry Letters, 2006, Vol.16(14), pp.3679-3683 [Peer Reviewed Journal]

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28
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Selecting against S1P 3 enhances the acute cardiovascular tolerability of 3-(N-benzyl)aminopropylphosphonic acid S1P receptor agonists

Hale, Jeffrey J ; Doherty, George ; Toth, Leslie ; Mills, Sander G ; Hajdu, Richard ; Ann Keohane, Carol ; Rosenbach, Mark ; Milligan, James ; Shei, Gan-Ju ; Chrebet, Gary ; Bergstrom, James ; Card, Deborah ; Forrest, Michael ; Sun, Shu-Yu ; West, Sarah ; Xie, Huijuan ; Nomura, Naomi ; Rosen, Hugh ; Mandala, Suzanne

Bioorganic & Medicinal Chemistry Letters, 2004, Vol.14(13), pp.3501-3505 [Peer Reviewed Journal]

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29
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Design and synthesis of conformationally constrained 3-(N-alkylamino)propylphosphonic acids as potent agonists of sphingosine-1-phosphate (S1P) receptors

Yan, Lin ; Hale, Jeffrey J ; Lynch, Christopher L ; Budhu, Richard ; Gentry, Amy ; Mills, Sander G ; Hajdu, Richard ; Keohane, Carol Ann ; Rosenbach, Mark J ; Milligan, James A ; Shei, Gan-Ju ; Chrebet, Gary ; Bergstrom, James ; Card, Deborah ; Rosen, Hugh ; Mandala, Suzanne M

Bioorganic & medicinal chemistry letters, 04 October 2004, Vol.14(19), pp.4861-6 [Peer Reviewed Journal]

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30
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Potent S1P receptor agonists replicate the pharmacologic actions of the novel immune modulator FTY720

Hale, Jeffrey J ; Neway, William ; Mills, Sander G ; Hajdu, Richard ; Ann Keohane, Carol ; Rosenbach, Mark ; Milligan, James ; Shei, Gan-Ju ; Chrebet, Gary ; Bergstrom, James ; Card, Deborah ; Koo, Gloria C ; Koprak, Sam L ; Jackson, Jesse J ; Rosen, Hugh ; Mandala, Suzanne

Bioorganic & Medicinal Chemistry Letters, 2004, Vol.14(12), pp.3351-3355 [Peer Reviewed Journal]

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31
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Design and synthesis of conformationally constrained 3-( N-alkylamino)propylphosphonic acids as potent agonists of sphingosine-1-phosphate (S1P) receptors

Yan, Lin ; Hale, Jeffrey J ; Lynch, Christopher L ; Budhu, Richard ; Gentry, Amy ; Mills, Sander G ; Hajdu, Richard ; Keohane, Carol Ann ; Rosenbach, Mark J ; Milligan, James A ; Shei, Gan-Ju ; Chrebet, Gary ; Bergstrom, James ; Card, Deborah ; Rosen, Hugh ; Mandala, Suzanne M

Bioorganic & Medicinal Chemistry Letters, 2004, Vol.14(19), pp.4861-4866 [Peer Reviewed Journal]

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32
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Hepatic responses to inhibition of 3-hydroxy-3-methylglutaryl-CoA reductase: a comparison of atorvastatin and simvastatin

Bergstrom, James D ; Bostedor, Richard G ; Rew, Deborah J ; Geissler, Wayne M ; Wright, Samuel D ; Chao, Yu-Sheng

Biochimica et Biophysica Acta (BBA)/Lipids and Lipid Metabolism, 1998, Vol.1389(3), pp.213-221

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33
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Infectious Agents Are Not Necessary for Murine Atherogenesis

Wright, Samuel D ; Burton, Charlotte ; Hernandez, Melba ; Hassing, Heide ; Montenegro, Judy ; Mundt, Steve ; Patel, Sushma ; Card, Deborah J ; Hermanowski-Vosatka, Anne ; Bergstrom, James D ; Sparrow, Carl P ; Detmers, Patricia A ; Chao, Yu-Sheng

The Journal of Experimental Medicine, 2000, Vol.191(8), p.1437-1442 [Peer Reviewed Journal]

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34
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Isolation, structure determination and squalene synthase activity of L-731,120 and L-731,128, alkyl citrate analogs of zaragozic acids A and B

Harris, Guy H ; Dufresne, Claude ; Joshua, Henry ; Koch, Leslie A ; Zink, Deborah L ; Salmon, Peter M ; Göklen, Kent E ; Kurtz, Marc M ; Rew, Deborah J ; Bergstrom, James D ; Wilson, Kenneth E

Bioorganic & Medicinal Chemistry Letters, 1995, Vol.5(20), pp.2403-2408 [Peer Reviewed Journal]

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35
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Distribution of zaragozic acids (squalestatins) among filamentous ascomycetes

Bills, Gerald F ; Peláez, Fernando ; Polishook, Jon D ; Diez-Matas, Maria Teresa ; Harris, Guy H ; Clapp, Wendy H ; Dufresne, Claude ; Byrne, Kevin M ; Nallin-Omstead, Mary ; Jenkins, Rosalind G ; Mojena, Marina ; Huang, Leeyuan ; Bergstrom, James D

Mycological Research, 1994, Vol.98(7), pp.733-739 [Peer Reviewed Journal]

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36
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Diesters of zaragozic acid A: Synthesis and biological activity

Chiang, Yuan-Ching P ; Biftu, Tesfaye ; Doss, George A ; Plevyak, Sandra P ; Marquis, Robert W ; Bergstrom, James D ; Kurtz, Marc M ; Rew, Deborah J ; Berger, Gregory D

Bioorganic & Medicinal Chemistry Letters, 1993, Vol.3(10), pp.2029-2034 [Peer Reviewed Journal]

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