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1
ATP as a multi-target danger signal in the brain
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ATP as a multi-target danger signal in the brain

Rodrigues, Ricardo J ; Tomé, Angelo R ; Cunha, Rodrigo A

Frontiers in neuroscience, 2015, Vol.9, p.148 [Peer Reviewed Journal]

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2
Caffeine as a Lead Compound for the Design of Therapeutic Agents for the Treatment of Parkinson's Disease
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Caffeine as a Lead Compound for the Design of Therapeutic Agents for the Treatment of Parkinson's Disease

Jacobus P. Petzer ; Anel Petzer

Current Medicinal Chemistry, 2015-03, Vol.22 (8), p.975-988 [Peer Reviewed Journal]

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3
Istradefylline as monotherapy for Parkinson disease: Results of the 6002-US-051 trial
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Istradefylline as monotherapy for Parkinson disease: Results of the 6002-US-051 trial

Fernandez, H.H ; Greeley, D.R ; Zweig, R.M ; Wojcieszek, J ; Mori, A ; Sussman, N.M

Parkinsonism & related disorders, 2010, Vol.16 (1), p.16-20 [Peer Reviewed Journal]

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4
Resveratrol-mediated reversal of changes in purinergic signaling and immune response induced by Toxoplasma gondii infection of neural progenitor cells
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Resveratrol-mediated reversal of changes in purinergic signaling and immune response induced by Toxoplasma gondii infection of neural progenitor cells

Bottari, Nathieli B ; Pillat, Micheli M ; Schetinger, Maria R.C ; Reichert, Karine P ; Machado, Vanessa ; Assmann, Charles E ; Ulrich, Henning ; Dutra, Anielen ; Morsch, Vera M ; Vidal, Taís ; Da Cruz, Ivana B. M ; Melazzo, Cinthia ; Da Silva, Aleksandro Schafer

Purinergic signalling, 2018, Vol.15 (1), p.77-84 [Peer Reviewed Journal]

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5
Systemic inflammation regulates microglial responses to tissue damage in vivo
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Systemic inflammation regulates microglial responses to tissue damage in vivo

Gyoneva, Stefka ; Davalos, Dimitrios ; Biswas, Dipankar ; Swanger, Sharon A ; Garnier-Amblard, Ethel ; Loth, Francis ; Akassoglou, Katerina ; Traynelis, Stephen F

Glia, 2014, Vol.62 (8), p.1345-1360 [Peer Reviewed Journal]

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6
Biased signalling: from simple switches to allosteric microprocessors
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Biased signalling: from simple switches to allosteric microprocessors

Smith, Jeffrey S ; Lefkowitz, Robert J ; Rajagopal, Sudarshan

Nature reviews. Drug discovery, 2018, Vol.17 (4), p.243-260 [Peer Reviewed Journal]

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7
Adenosine receptors as drug targets — what are the challenges?
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Adenosine receptors as drug targets — what are the challenges?

Chen, Jiang-Fan ; Eltzschig, Holger K ; Fredholm, Bertil B

Nature reviews. Drug discovery, 2013, Vol.12 (4), p.265-286 [Peer Reviewed Journal]

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8
Structure-based discovery of opioid analgesics with reduced side effects
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Structure-based discovery of opioid analgesics with reduced side effects

Manglik, Aashish ; Lin, Henry ; Aryal, Dipendra K ; McCorvy, John D ; Dengler, Daniela ; Corder, Gregory ; Levit, Anat ; Kling, Ralf C ; Bernat, Viachaslau ; Hübner, Harald ; Huang, Xi-Ping ; Sassano, Maria F ; Giguère, Patrick M ; Löber, Stefan ; Da Duan ; Scherrer, Grégory ; Kobilka, Brian K ; Gmeiner, Peter ; Roth, Bryan L ; Shoichet, Brian K

Nature (London), 2016, Vol.537 (7619), p.185-190 [Peer Reviewed Journal]

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9
Diversity and modularity of G protein-coupled receptor structures
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Diversity and modularity of G protein-coupled receptor structures

Katritch, Vsevolod ; Cherezov, Vadim ; Stevens, Raymond C

Trends in pharmacological sciences (Regular ed.), 2012, Vol.33 (1), p.17-27 [Peer Reviewed Journal]

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10
Adenosine as a Multi-Signalling Guardian Angel in Human Diseases: When, Where and How Does it Exert its Protective Effects?
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Adenosine as a Multi-Signalling Guardian Angel in Human Diseases: When, Where and How Does it Exert its Protective Effects?

Borea, Pier Andrea ; Gessi, Stefania ; Merighi, Stefania ; Varani, Katia

Trends in pharmacological sciences (Regular ed.), 2016, Vol.37 (6), p.419-434 [Peer Reviewed Journal]

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11
Structural Basis for Allosteric Regulation of GPCRs by Sodium Ions
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Structural Basis for Allosteric Regulation of GPCRs by Sodium Ions

Liu, W ; Chun, E ; Thompson, A. A ; Chubukov, P ; Xu, F ; Katritch, V ; Han, G. W ; Roth, C. B ; Heitman, L. H ; IJzerman, A. P ; Cherezov, V ; Stevens, R. C

Science (American Association for the Advancement of Science), 2012, Vol.337 (6091), p.232-236 [Peer Reviewed Journal]

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12
A Metabolic Immune Checkpoint: Adenosine in Tumor Microenvironment
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A Metabolic Immune Checkpoint: Adenosine in Tumor Microenvironment

Ohta, Akio

Frontiers in immunology, 2016, Vol.7, p.109 [Peer Reviewed Journal]

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13
Kinetics for Drug Discovery: an industry-driven effort to target drug residence time
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Kinetics for Drug Discovery: an industry-driven effort to target drug residence time

Schuetz, Doris A ; de Witte, Wilhelmus Egbertus Arnout ; Wong, Yin Cheong ; Knasmueller, Bernhard ; Richter, Lars ; Kokh, Daria B ; Sadiq, S. Kashif ; Bosma, Reggie ; Nederpelt, Indira ; Heitman, Laura H ; Segala, Elena ; Amaral, Marta ; Guo, Dong ; Andres, Dorothee ; Georgi, Victoria ; Stoddart, Leigh A ; Hill, Steve ; Cooke, Robert M ; De Graaf, Chris ; Leurs, Rob ; Frech, Matthias ; Wade, Rebecca C ; de Lange, Elizabeth Cunera Maria ; IJzerman, Adriaan P ; Müller-Fahrnow, Anke ; Ecker, Gerhard F

Drug discovery today, 2017-06, Vol.22 (6), p.896-911 [Peer Reviewed Journal]

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14
On the role of A2A and D2 receptors in control of cocaine and food-seeking behaviors in rats
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On the role of A2A and D2 receptors in control of cocaine and food-seeking behaviors in rats

Wydra, Karolina ; Suder, Agata ; Borroto-Escuela, Dasiel O ; Filip, Malgorzata ; Fuxe, Kjell

Psychopharmacology (Berlin, Germany), 2014, Vol.232 (10), p.1767-1778 [Peer Reviewed Journal]

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15
Regulation of Inflammation by Adenosine
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Regulation of Inflammation by Adenosine

Haskó, György ; Cronstein, Bruce

Frontiers in immunology, 2013, Vol.4, p.85 [Peer Reviewed Journal]

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16
Physiology and Pathophysiology of Purinergic Neurotransmission
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Physiology and Pathophysiology of Purinergic Neurotransmission

Burnstock, Geoffrey

Physiological Reviews, 2007, Vol.87 (2), p.659-797 [Peer Reviewed Journal]

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17
Recent developments in adenosine receptor ligands and their potential as novel drugs
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Recent developments in adenosine receptor ligands and their potential as novel drugs

Müller, Christa E ; Jacobson, Kenneth A

Biochimica et biophysica acta. Biomembranes, 2011, Vol.1808 (5), p.1290-1308 [Peer Reviewed Journal]

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18
Advances in the pharmacological treatment of Parkinson's disease: targeting neurotransmitter systems
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Advances in the pharmacological treatment of Parkinson's disease: targeting neurotransmitter systems

Brichta, Lars ; Greengard, Paul ; Flajolet, Marc

Trends in neurosciences (Regular ed.), 2013, Vol.36 (9), p.543-554 [Peer Reviewed Journal]

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19
Activation of G-protein-coupled receptors correlates with the formation of a continuous internal water pathway
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Activation of G-protein-coupled receptors correlates with the formation of a continuous internal water pathway

Yuan, Shuguang ; Filipek, Slawomir ; Palczewski, Krzysztof ; Vogel, Horst

Nature communications, 2014, Vol.5 (1), p.4733 [Peer Reviewed Journal]

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20
New paradigms in GPCR drug discovery
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New paradigms in GPCR drug discovery

Jacobson, Kenneth A

Biochemical pharmacology, 2015-12-15, Vol.98 (4), p.541-555 [Peer Reviewed Journal]

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21
Adenosine receptors: therapeutic aspects for inflammatory and immune diseases
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Adenosine receptors: therapeutic aspects for inflammatory and immune diseases

Haskó, György ; Linden, Joel ; Cronstein, Bruce ; Pacher, Pál

Nature reviews. Drug discovery, 2008, Vol.7 (9), p.759-770 [Peer Reviewed Journal]

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22
Immunosuppressive activities of adenosine in cancer
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Immunosuppressive activities of adenosine in cancer

Allard, Bertrand ; Beavis, Paul A ; Darcy, Phillip K ; Stagg, John

Current opinion in pharmacology, 2016, Vol.29, p.7-16 [Peer Reviewed Journal]

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23
Getting personal: Endogenous adenosine receptor signaling in lymphoblastoid cell lines
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Getting personal: Endogenous adenosine receptor signaling in lymphoblastoid cell lines

Hillger, J.M ; Diehl, C ; van Spronsen, E ; Boomsma, D.I ; Slagboom, P.E ; Heitman, L.H ; IJzerman, A.P

Biochemical pharmacology, 2016-09-01, Vol.115, p.114-122 [Peer Reviewed Journal]

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24
Active state structures of G protein-coupled receptors highlight the similarities and differences in the G protein and arrestin coupling interfaces
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Active state structures of G protein-coupled receptors highlight the similarities and differences in the G protein and arrestin coupling interfaces

Carpenter, Byron ; Tate, Christopher G

Current opinion in structural biology, 2017, Vol.45, p.124-132 [Peer Reviewed Journal]

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25
Adenosine, an endogenous distress signal, modulates tissue damage and repair
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Adenosine, an endogenous distress signal, modulates tissue damage and repair

Fredholm, B B

Cell death and differentiation, 2007, Vol.14 (7), p.1315-1323 [Peer Reviewed Journal]

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26
New insights from structural biology into the druggability of G protein-coupled receptors
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New insights from structural biology into the druggability of G protein-coupled receptors

Mason, Jonathan S ; Bortolato, Andrea ; Congreve, Miles ; Marshall, Fiona H

Trends in pharmacological sciences (Regular ed.), 2012, Vol.33 (5), p.249-260 [Peer Reviewed Journal]

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27
G-protein-coupled receptor inactivation by an allosteric inverse-agonist antibody
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G-protein-coupled receptor inactivation by an allosteric inverse-agonist antibody

Hino, Tomoya ; Arakawa, Takatoshi ; Iwanari, Hiroko ; Yurugi-Kobayashi, Takami ; Ikeda-Suno, Chiyo ; Nakada-Nakura, Yoshiko ; Kusano-Arai, Osamu ; Weyand, Simone ; Shimamura, Tatsuro ; Nomura, Norimichi ; Cameron, Alexander D ; Kobayashi, Takuya ; Hamakubo, Takao ; Iwata, So ; Murata, Takeshi

Nature (London), 2012, Vol.482 (7384), p.237-240 [Peer Reviewed Journal]

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28
GPCR drug discovery: integrating solution NMR data with crystal and cryo-EM structures
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GPCR drug discovery: integrating solution NMR data with crystal and cryo-EM structures

Shimada, Ichio ; Ueda, Takumi ; Kofuku, Yutaka ; Eddy, Matthew T ; Wüthrich, Kurt

Nature reviews. Drug discovery, 2018, Vol.18 (1), p.59-82 [Peer Reviewed Journal]

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29
Adenosine receptor targets for pain
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Adenosine receptor targets for pain

Sawynok, J

Neuroscience, 2016, Vol.338, p.1-18 [Peer Reviewed Journal]

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30
De novo vesicle formation and growth: an integrative approach to artificial cells
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De novo vesicle formation and growth: an integrative approach to artificial cells

Bhattacharya, Ahanjit ; Brea, Roberto J ; Devaraj, Neal K

Chemical science (Cambridge), 2017-11-20, Vol.8 (12), p.7912-7922 [Peer Reviewed Journal]

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31
Adenosine Production by Biomaterial‐Supported Mesenchymal Stromal Cells Reduces the Innate Inflammatory Response in Myocardial Ischemia/Reperfusion Injury
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Adenosine Production by Biomaterial‐Supported Mesenchymal Stromal Cells Reduces the Innate Inflammatory Response in Myocardial Ischemia/Reperfusion Injury

Shin, Eric Y ; Wang, Lanfang ; Zemskova, Marina ; Deppen, Juline ; Xu, Kai ; Strobel, Frederick ; García, Andrés J ; Tirouvanziam, Rabindra ; Levit, Rebecca D

Journal of the American Heart Association, 2018, Vol.7 (2), p.n/a [Peer Reviewed Journal]

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32
How does adenosine control neuronal dysfunction and neurodegeneration?
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How does adenosine control neuronal dysfunction and neurodegeneration?

Cunha, Rodrigo A

Journal of neurochemistry, 2016, Vol.139 (6), p.1019-1055 [Peer Reviewed Journal]

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33
Targeting Adenosine Receptor Signaling in Cancer Immunotherapy
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Targeting Adenosine Receptor Signaling in Cancer Immunotherapy

Sek, Kevin ; Mølck, Christina ; Stewart, Gregory ; Kats, Lev ; Darcy, Phillip ; Beavis, Paul

International journal of molecular sciences, 2018, Vol.19 (12), p.3837 [Peer Reviewed Journal]

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34
Using caffeine and other adenosine receptor antagonists and agonists as therapeutic tools against neurodegenerative diseases: A review
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Using caffeine and other adenosine receptor antagonists and agonists as therapeutic tools against neurodegenerative diseases: A review

Rivera-Oliver, Marla ; Díaz-Ríos, Manuel

Life sciences (1973), 2014, Vol.101 (1-2), p.1-9 [Peer Reviewed Journal]

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35
Barriers to Radiation-Induced In Situ Tumor Vaccination
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Barriers to Radiation-Induced In Situ Tumor Vaccination

Wennerberg, Erik ; Lhuillier, Claire ; Vanpouille-Box, Claire ; Pilones, Karsten A ; García-Martínez, Elena ; Rudqvist, Nils-Petter ; Formenti, Silvia C ; Demaria, Sandra

Frontiers in immunology, 2017, Vol.8, p.229 [Peer Reviewed Journal]

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36
How Can Mutations Thermostabilize G-Protein-Coupled Receptors?
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How Can Mutations Thermostabilize G-Protein-Coupled Receptors?

Vaidehi, Nagarajan ; Grisshammer, Reinhard ; Tate, Christopher G

Trends in pharmacological sciences (Regular ed.), 2016, Vol.37 (1), p.37-46 [Peer Reviewed Journal]

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