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Pharmacokinetics, pharmacodynamics, safety, and tolerability of pradigastat, a novel diacylglycerol acyltransferase 1 inhibitor in overweight or obese, but otherwise healthy human subjects

Meyers, Charles D. ; Amer, Ahmed ; Majumdar, Tapan ; Chen, Jin

Journal of Clinical Pharmacology, September 2015, Vol.55(9), pp.1031-1041 [Peer Reviewed Journal]

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Discovery of novel quinoline carboxylic acid series as DGAT1 inhibitors

Zhou, Gang ; Ting, Pauline C ; Wishart, Grant ; Zorn, Nicolas ; Aslanian, Robert G ; Lin, Mingxiang ; Smith, Michelle ; Walker, Scott S ; Cook, John ; Van Heek, Margaret ; Lachowicz, Jean

Bioorganic & Medicinal Chemistry Letters, 01 April 2014, Vol.24(7), pp.1790-1794 [Peer Reviewed Journal]

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DS-7250, a Diacylglycerol Acyltransferase 1 Inhibitor, Enhances Hepatic Steatosis in Zucker Fatty Rats via Upregulation of Fatty Acid Synthesis

Yasuno, Kyohei ; Kumagai, Kazuyoshi ; Iguchi, Takuma ; Tsuchiya, Yoshimi ; Kai, Kiyonori ; Mori, Kazuhiko

Toxicologic Pathology, April 2018, Vol.46(3), pp.302-311 [Peer Reviewed Journal]

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A pharmacologic increase in activity of plasma transaminase derived from small intestine in animals receiving an acyl CoA: diacylglycerol transferase (DGAT) 1 inhibitor

Yokoyama, Hideaki ; Kobayashi, Akio ; Kondo, Kazuma ; Oshida, Shin-Ichi ; Takahashi, Tadakazu ; Masuyama, Taku ; Shoda, Toshiyuki ; Sugai, Shoichiro

The Journal of Toxicological Sciences, 2018, Vol.43(2), pp.135-157 [Peer Reviewed Journal]

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