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Refined by: Subject: Anti-HIV Agents remove
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CCR5 antagonists: 3-(pyrrolidin-1-yl)propionic acid analogues with potent anti-HIV activity

Lynch, Christopher L ; Hale, Jeffrey J ; Budhu, Richard J ; Gentry, Amy L ; Finke, Paul E ; Caldwell, Charles G ; Mills, Sander G ; Maccoss, Malcolm ; Shen, Dong-Ming ; Chapman, Kevin T ; Malkowitz, Lorraine ; Springer, Martin S ; Gould, Sandra L ; Demartino, Julie A ; Siciliano, Salvatore J ; Cascieri, Margaret A ; Carella, Anthony ; Carver, Gwen ; Holmes, Karen ; Schleif

Organic letters, 10 July 2003, Vol.5(14), pp.2473-5 [Peer Reviewed Journal]

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1,3,4-Trisubstituted pyrrolidine CCR5 receptor antagonists. Part 3: polar functionality and its effect on anti-HIV-1 activity

Hale, Jeffrey J ; Budhu, Richard J ; Mills, Sander G ; Maccoss, Malcolm ; Gould, Sandra L ; Demartino, Julie A ; Springer, Martin S ; Siciliano, Salvatore J ; Malkowitz, Lorraine ; Schleif, William A ; Hazuda, Daria ; Miller, Michael ; Kessler, Joseph ; Danzeisen, Renee ; Holmes, Karen ; Lineberger, Janet ; Carella, Anthony ; Carver, Gwen ; Emini, Emilio A

Bioorganic & Medicinal Chemistry Letters, 21 October 2002, Vol.12(20), pp.2997-3000 [Peer Reviewed Journal]

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Potent 1,3,4-trisubstituted pyrrolidine CCR5 receptor antagonists: effects of fused heterocycles on antiviral activity and pharmacokinetic properties

Kim, Dooseop ; Wang, Liping ; Hale, Jeffrey J ; Lynch, Christopher L ; Budhu, Richard J ; Maccoss, Malcolm ; Mills, Sander G ; Malkowitz, Lorraine ; Gould, Sandra L ; Demartino, Julie A ; Springer, Martin S ; Hazuda, Daria ; Miller, Michael ; Kessler, Joseph ; Hrin, Renee C ; Carver, Gwen ; Carella, Anthony ; Henry, Karen ; Lineberger, Janet ; Schleif, William A ; Emini, Emilio A

Bioorganic & Medicinal Chemistry Letters, 2005, Vol.15(8), pp.2129-2134 [Peer Reviewed Journal]

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1,3,4-Trisubstituted pyrrolidine CCR5 receptor antagonists. Part 4: Synthesis of N-1 acidic functionality affording analogues with enhanced antiviral activity against HIV

Lynch, Christopher L ; Hale, Jeffrey J ; Budhu, Richard J ; Gentry, Amy L ; Mills, Sander G ; Chapman, Kevin T ; Maccoss, Malcolm ; Malkowitz, Lorraine ; Springer, Martin S ; Gould, Sandra L ; Demartino, Julie A ; Siciliano, Salvatore J ; Cascieri, Margaret A ; Carella, Anthony ; Carver, Gwen ; Holmes, Karen ; Schleif, William A ; Danzeisen, Renee ; Hazuda, Daria ; Kessler, Joseph

Bioorganic & Medicinal Chemistry Letters, 21 October 2002, Vol.12(20), pp.3001-3004 [Peer Reviewed Journal]

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1,3,4 trisubstituted pyrrolidine CCR5 receptor antagonists bearing 4-aminoheterocycle substituted piperidine side chains

Willoughby, Christopher A ; Rosauer, Keith G ; Hale, Jeffery J ; Budhu, Richard J ; Mills, Sander G ; Chapman, Kevin T ; Maccoss, Malcolm ; Malkowitz, Lorraine ; Springer, Martin S ; Gould, Sandra L ; Demartino, Julie A ; Siciliano, Salvatore J ; Cascieri, Margaret A ; Carella, Anthony ; Carver, Gwen ; Holmes, Karen ; Schleif, William A ; Danzeisen, Renee ; Hazuda, Daria ; Kessler, Joseph

Bioorganic & Medicinal Chemistry Letters, 2003, Vol.13(3), pp.427-431 [Peer Reviewed Journal]

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Antagonists of the human CCR5 receptor as anti-HIV-1 agents. Part 1: Discovery and initial structure–activity relationships for 1-amino-2-phenyl-4-(piperidin-1-yl)butanes

Dorn, Conrad P ; Finke, Paul E ; Oates, Bryan ; Budhu, Richard J ; Mills, Sander G ; Maccoss, Malcolm ; Malkowitz, Lorraine ; Springer, Martin S ; Daugherty, Bruce L ; Gould, Sandra L ; Demartino, Julie A ; Siciliano, Salvatore J ; Carella, Anthony ; Carver, Gwen ; Holmes, Karen ; Danzeisen, Renee ; Hazuda, Daria ; Kessler, Joseph ; Lineberger, Janet ; Miller, Michael

Bioorganic & Medicinal Chemistry Letters, January 2001, Vol.11(2), pp.259-264 [Peer Reviewed Journal]

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1,3,4-Trisubstituted pyrrolidine CCR5 receptor antagonists. Part 2: lead optimization affording selective, orally bioavailable compounds with potent Anti-HIV activity

Hale, Jeffrey J ; Budhu, Richard J ; Holson, Edward B ; Finke, Paul E ; Oates, Bryan ; Mills, Sander G ; Maccoss, Malcolm ; Gould, Sandra L ; Demartino, Julie A ; Springer, Martin S ; Siciliano, Salvatore ; Malkowitz, Lorraine ; Schleif, William A ; Hazuda, Daria ; Miller, Michael ; Kessler, Joseph ; Danzeisen, Renee ; Holmes, Karen ; Lineberger, Janet ; Carella, Anthony

Bioorganic & Medicinal Chemistry Letters, 2001, Vol.11(20), pp.2741-2745 [Peer Reviewed Journal]

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1,3,4-Trisubstituted pyrrolidine CCR5 receptor antagonists: modifications of the arylpropylpiperidine side chains

Lynch, Christopher L ; Willoughby, Christopher A ; Hale, Jeffrey J ; Holson, Edward J ; Budhu, Richard J ; Gentry, Amy L ; Rosauer, Keith G ; Caldwell, Charles G ; Chen, Ping ; Mills, Sander G ; Maccoss, Malcolm ; Berk, Scott ; Chen, Liya ; Chapman, Kevin T ; Malkowitz, Lorraine ; Springer, Martin S ; Gould, Sandra L ; Demartino, Julie A ; Siciliano, Salvatore J ; Cascieri, Margaret A

Bioorganic & Medicinal Chemistry Letters, 2003, Vol.13(1), pp.119-123 [Peer Reviewed Journal]

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