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12 Results  for Everything (Includes Articles)

Refined by: Subject: Animals remove
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Irreversible protein kinase inhibitors: balancing the benefits and risks

Barf, Tjeerd ; Kaptein, Allard

Journal of medicinal chemistry, 26 July 2012, Vol.55(14), pp.6243-62 [Peer Reviewed Journal]

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In vivo knockdown of TAK1 accelerates bone marrow proliferation/differentiation and induces systemic inflammation

Vink, Paul M ; Smout, Wendy M ; Driessen-Engels, Lilian J ; De Bruin, Alex M ; Delsing, Dianne ; Krajnc-Franken, Magda A ; Jansen, Aswin J ; Rovers, Eric F ; Van Puijenbroek, André A ; Kaptein, Allard ; Nolte, Martijn A ; Garritsen, Anja ; Van Eenennaam, Hans

PloS one, 2013, Vol.8(3), pp.e57348 [Peer Reviewed Journal]

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Preclinical Evaluation of the Novel BTK Inhibitor Acalabrutinib in Canine Models of B-Cell Non-Hodgkin Lymphoma

Harrington, Bonnie K ; Gardner, Heather L ; Izumi, Raquel ; Hamdy, Ahmed ; Rothbaum, Wayne ; Coombes, Kevin R ; Covey, Todd ; Kaptein, Allard ; Gulrajani, Michael ; Van Lith, Bart ; Krejsa, Cecile ; Coss, Christopher C ; Russell, Duncan S ; Zhang, Xiaoli ; Urie, Bridget K ; London, Cheryl A ; Byrd, John C ; Johnson, Amy J ; Kisseberth, William C Richards, Kristy L. (editor)

PLoS ONE, 2016, Vol.11(7) [Peer Reviewed Journal]

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The Bruton Tyrosine Kinase (BTK) Inhibitor Acalabrutinib Demonstrates Potent On-Target Effects and Efficacy in Two Mouse Models of Chronic Lymphocytic Leukemia

Herman, Sarah E M ; Montraveta, Arnau ; Niemann, Carsten U ; Mora-Jensen, Helena ; Gulrajani, Michael ; Krantz, Fanny ; Mantel, Rose ; Smith, Lisa L ; Mcclanahan, Fabienne ; Harrington, Bonnie K ; Colomer, Dolors ; Covey, Todd ; Byrd, John C ; Izumi, Raquel ; Kaptein, Allard ; Ulrich, Roger ; Johnson, Amy J ; Lannutti, Brian J ; Wiestner, Adrian ; Woyach

Clinical cancer research : an official journal of the American Association for Cancer Research, 01 June 2017, Vol.23(11), pp.2831-2841 [Peer Reviewed Journal]

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Severity of murine collagen‐induced arthritis correlates with increased CYP7B activity: Enhancement of dehydroepiandrosterone metabolism by interleukin‐1β

Dulos, John ; Verbraak, Evert ; Bagchus, Wilma M. ; Boots, Annemieke M. H. ; Kaptein, Allard

Arthritis & Rheumatism, October 2004, Vol.50(10), pp.3346-3353 [Peer Reviewed Journal]

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Acalabrutinib (ACP-196): A Covalent Bruton Tyrosine Kinase Inhibitor with a Differentiated Selectivity and In Vivo Potency Profile

Barf, Tjeerd ; Covey, Todd ; Izumi, Raquel ; Van De Kar, Bas ; Gulrajani, Michael ; Van Lith, Bart ; Van Hoek, Maaike ; De Zwart, Edwin ; Mittag, Diana ; Demont, Dennis ; Verkaik, Saskia ; Krantz, Fanny ; Pearson, Paul G ; Ulrich, Roger ; Kaptein, Allard

The Journal of pharmacology and experimental therapeutics, November 2017, Vol.363(2), pp.240-252 [Peer Reviewed Journal]

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The IL1 receptor accessory protein is responsible for the recruitment of the interleukin-1 receptor associated kinase to the IL1/IL1 receptor I complex

Volpe, Filippo ; Clatworthy, Jonathan ; Kaptein, Allard ; Maschera, Barbara ; Griffin, Anne-Marie ; Ray, Keith

FEBS Letters, 1997, Vol.419(1), pp.41-44 [Peer Reviewed Journal]

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Discovery of selective and orally available spiro-3-piperidyl ATP-competitive MK2 inhibitors

Kaptein, Allard ; Oubrie, Arthur ; Zwart, Edwin de ; Hoogenboom, Niels ; Wit, Joeri de ; Kar, Bas van de ; Hoek, Maaike van ; Vogel, Gerard ; Kimpe, Vera de ; Schultz-Fademrecht, Carsten ; Borsboom, Judith ; Zeeland, Mario van ; Versteegh, Judith ; Kazemier, Bert ; Roos, Jeroen de ; Wijnands, Frank ; Dulos, John ; Jaeger, Martin ; Leandro-Garcia, Paula ; Barf, Tjeerd

Bioorganic & Medicinal Chemistry Letters, 2011, Vol.21(12), pp.3823-3827 [Peer Reviewed Journal]

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Structure-based lead identification of ATP-competitive MK2 inhibitors

Barf, Tjeerd ; Kaptein, Allard ; Wilde, Sander de ; Heijden, Ruud van Der ; Someren, Richard van ; Demont, Dennis ; Schultz-Fademrecht, Carsten ; Versteegh, Judith ; Zeeland, Mario van ; Seegers, Nicole ; Kazemier, Bert ; Kar, Bas van de ; Hoek, Maaike van ; Roos, Jeroen de ; Klop, Henri ; Smeets, Ruben ; Hofstra, Claudia ; Hornberg, Jorrit ; Oubrie, Arthur

Bioorganic & Medicinal Chemistry Letters, 2011, Vol.21(12), pp.3818-3822 [Peer Reviewed Journal]

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6-Phenyl-1H-imidazo[4,5-c]pyridine-4-carbonitrile as cathepsin S inhibitors

Cai, Jiaqiang ; Baugh, Mark ; Black, Darcey ; Long, Clive ; Jonathan Bennett, D ; Dempster, Maureen ; Fradera, Xavier ; Gillespie, Jonathan ; Andrews, Fiona ; Boucharens, Sylviane ; Bruin, John ; Cameron, Kenneth S ; Cumming, Iain ; Hamilton, William ; Jones, Philip S ; Kaptein, Allard ; Kinghorn, Emma ; Maidment, Maurice ; Martin, Iain ; Mitchell, Ann

Bioorganic & Medicinal Chemistry Letters, 01 August 2010, Vol.20(15), pp.4350-4354 [Peer Reviewed Journal]

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Studies on the interaction between TWEAK and the death receptor WSL-1/TRAMP (DR3)

Kaptein, Allard ; Jansen, Mieke ; Dilaver, Gonul ; Kitson, Jeremy ; Dash, Laura ; Wang, Edward ; Owen, Michael J ; Bodmer, Jean-Luc ; Tschopp, Jurg ; Farrow, Stuart N

FEBS Letters, 2000, Vol.485(2), pp.135-141 [Peer Reviewed Journal]

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No Effect of Fibrates on Synthesis of Apolipoprotein(a) in Primary Cultures of Cynomolgus Monkey and Human Hepatocytes: Apolipoprotein A-I Synthesis Increased

Neele, Diana M ; Kaptein, Allard ; Huisman, Holger ; de Wit, Elly C.M ; Princen, Hans M.G

Biochemical and Biophysical Research Communications, 17 March 1998, Vol.244(2), pp.374-378 [Peer Reviewed Journal]

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