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Bioisosteric replacement of anilide with benzoxazole: potent and orally bioavailable antagonists of VLA-4

Lin, Linus S ; Lanza, Thomas J ; Castonguay, Laurie A ; Kamenecka, Theodore ; Mccauley, Ermenegilda ; Van Riper, Gail ; Egger, Linda A ; Mumford, Richard A ; Tong, Xinchun ; Maccoss, Malcolm ; Schmidt, John A ; Hagmann, William K

Bioorganic & Medicinal Chemistry Letters, 3 May 2004, Vol.14(9), pp.2331-2334 [Peer Reviewed Journal]

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N-Aryl-prolyl-dipeptides as potent antagonists of VLA-4

Kamenecka, Theodore M. ; Lanza, Jr., Thomas ; de Laszlo, Stephen E. ; Li, Bing ; Mccauley, Ermengilda D. ; Van Riper, Gail ; Egger, Linda A. ; Kidambi, Usha ; Mumford, Richard A. ; Tong, Sharon ; Maccoss, Malcolm ; Schmidt, John A. ; Hagmann, William K.

Bioorganic & Medicinal Chemistry Letters, 2002, Vol.12(16), pp.2205-2208 [Peer Reviewed Journal]

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N-Tetrahydrofuroyl-( l)-phenylalanine derivatives as potent VLA-4 antagonists

Yang, Ginger X. ; Chang, Linda L. ; Truong, Quang ; Doherty, George A. ; Magriotis, Plato A. ; de Laszlo, Stephen E. ; Li, Bing ; Maccoss, Malcolm ; Kidambi, Usha ; Egger, Linda A. ; Mccauley, Ermengilda ; Van Riper, Gail ; Mumford, Richard A. ; Schmidt, John A. ; Hagmann, William K.

Bioorganic & Medicinal Chemistry Letters, 2002, Vol.12(11), pp.1497-1500 [Peer Reviewed Journal]

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Substituted tetrahydrofuroyl-1-phenylalanine derivatives as potent and specific VLA-4 antagonists

Doherty, George A. ; Yang, Ginger X. ; Borges, Edite ; Chang, Linda L. ; Maccoss, Malcolm ; Tong, Sharon ; Kidambi, Usha ; Egger, Linda A. ; Mccauley, Ermenegilda ; Van Riper, Gail ; Mumford, Richard A. ; Schmidt, John A. ; Hagmann, William K.

Bioorganic & Medicinal Chemistry Letters, 2002, Vol.12(11), pp.1501-1505 [Peer Reviewed Journal]

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Alpha(4)beta(7)/alpha(4)beta(1) dual integrin antagonists block alpha(4)beta(7)-dependent adhesion under shear flow

Egger, Linda A ; Kidambi, Usha ; Cao, Jin ; Van Riper, Gail ; Mccauley, Ermengilda ; Mumford, Richard A ; Amo, Suzanne ; Lingham, Russell ; Lanza, Thomas ; Lin, Linus S ; De Laszlo, Stephen E ; Young, David N ; Kopka, Ihor E ; Tong, Sharon ; Pikounis, Bill ; Benson, Evelyn ; Warwood, Sarah ; Bargatze, Robert F ; Hagmann, William K ; Schmidt, John A ; Detmers, Patricia A

The Journal of pharmacology and experimental therapeutics, July 2002, Vol.302(1), pp.153-62 [Peer Reviewed Journal]

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Cyclopentane-based human NK1 antagonists. Part 2: Development of potent, orally active, water-soluble derivatives

Meurer, Laura C. ; Finke, Paul E. ; Owens, Karen A. ; Tsou, Nancy N. ; Ball, Richard G. ; Mills, Sander G. ; Maccoss, Malcolm ; Sadowski, Sharon ; Cascieri, Margaret A. ; Tsao, Kwei-Lan ; Chicchi, Gary G. ; Egger, Linda A. ; Luell, Silvi ; Metzger, Joseph M. ; Macintyre, D. Euan ; Rupniak, Nadia M.J. ; Williams, Angela R. ; Hargreaves, Richard J.

Bioorganic & Medicinal Chemistry Letters, 2006, Vol.16(17), pp.4504-4511 [Peer Reviewed Journal]

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The discovery of sulfonylated dipeptides as Potent VLA-4 antagonists

Hagmann, William K ; Durette, Philippe L ; Lanza, Thomas ; Kevin, Nancy Jo ; de Laszlo, Stephen E ; Kopka, Ihor E ; Young, David ; Magriotis, Plato A ; Li, Bing ; Lin, Linus S ; Yang, Ginger ; Kamenecka, Theodore ; Chang, Linda L ; Wilson, Jonathan ; Maccoss, Malcolm ; Mills, Sander G ; Van Riper, Gail ; Mccauley, Ermengilda ; Egger, Linda A ; Kidambi, Usha ; Lyons, Kathryn ; Vincent, Stella ; Stearns, Ralph ; Colletti, Adria ; Teffera, Johannes ; Tong, Sharon ; Fenyk-Melody, Judy ; Owens, Karen ; Levorse, Dorothy ; Kim, Philip ; Schmidt, John A ; Mumford, Richard A

Bioorganic & Medicinal Chemistry Letters, 2001, Vol.11(20), pp.2709-2713 [Peer Reviewed Journal]

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The discovery of acylated beta-amino acids as potent and orally bioavailable VLA-4 antagonists

Lin, Linus S ; Kopka, Ihor E ; Mumford, Richard A ; Magriotis, Plato A ; Lanza, Thomas ; Durette, Philippe L ; Kamenecka, Theodore ; Young, David N ; De Laszlo, Stephen E ; Mccauley, Ermenegilda ; Riper, Gail Van ; Kidambi, Usha ; Egger, Linda A ; Tong, Xinchun ; Lyons, Kathryn ; Vincent, Stella ; Stearns, Ralph ; Colletti, Adria ; Teffera, Yohannes ; Fenyk-Melody, Judy ; Schmidt, John A ; Maccoss, Malcolm ; Hagmann, William K

Bioorganic & medicinal chemistry letters, 25 February 2002, Vol.12(4), pp.611-4 [Peer Reviewed Journal]

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