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1
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The discovery of small molecule carbamates as potent dual alpha(4)beta(1)/alpha(4)beta(7) integrin antagonists

Chang, Linda L ; Truong, Quang ; Mumford, Richard A ; Egger, Linda A ; Kidambi, Usha ; Lyons, Kathryn ; Mccauley, Ermengilda ; Van Riper, Gail ; Vincent, Stella ; Schmidt, John A ; Maccoss, Malcolm ; Hagmann, William K

Bioorganic & medicinal chemistry letters, 21 January 2002, Vol.12(2), pp.159-63 [Peer Reviewed Journal]

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2
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Isoxazolyl, oxazolyl, and thiazolylpropionic acid derivatives as potent alpha(4)beta(1) integrin antagonists

Duplantier, A J ; Beckius, G E ; Chambers, R J ; Chupak, L S ; Jenkinson, T H ; Klein, A S ; Kraus, K G ; Kudlacz, E M ; Mckechney, M W ; Pettersson, M P ; Whitney, C A ; Milici, A J

Bioorganic & medicinal chemistry letters, 08 October 2001, Vol.11(19), pp.2593-6 [Peer Reviewed Journal]

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3
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Synthesis of a peptidomimetic tricyclic tetrahydrobenzoijquinoline as a VLA-4 antagonist

Ho, W B ; Broka, C

The Journal of organic chemistry, 06 October 2000, Vol.65(20), pp.6743-8 [Peer Reviewed Journal]

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4
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N-aryl 2,6-dimethoxybiphenylalanine analogues as VLA-4 antagonists

Doherty, George A ; Kamenecka, Theodore ; Mccauley, Ermenegilda ; Van Riper, Gail ; Mumford, Richard A ; Tong, Sharon ; Hagmann, William K

Bioorganic & medicinal chemistry letters, 11 March 2002, Vol.12(5), pp.729-31 [Peer Reviewed Journal]

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5
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Alpha(4)beta(7)/alpha(4)beta(1) dual integrin antagonists block alpha(4)beta(7)-dependent adhesion under shear flow

Egger, Linda A ; Kidambi, Usha ; Cao, Jin ; Van Riper, Gail ; Mccauley, Ermengilda ; Mumford, Richard A ; Amo, Suzanne ; Lingham, Russell ; Lanza, Thomas ; Lin, Linus S ; De Laszlo, Stephen E ; Young, David N ; Kopka, Ihor E ; Tong, Sharon ; Pikounis, Bill ; Benson, Evelyn ; Warwood, Sarah ; Bargatze, Robert F ; Hagmann, William K ; Schmidt, John A ; Detmers, Patricia A

The Journal of pharmacology and experimental therapeutics, July 2002, Vol.302(1), pp.153-62 [Peer Reviewed Journal]

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6
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Discovery and evaluation of piperidinyl carboxylic acid derivatives as potent alpha(4)beta(1) integrin antagonists

Müller, G ; Albers, M ; Fischer, R ; Hessler, G ; Lehmann, T E ; Okigami, H ; Tajimi, M ; Bacon, K ; Rölle, T

Bioorganic & medicinal chemistry letters, 03 December 2001, Vol.11(23), pp.3019-21 [Peer Reviewed Journal]

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7
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Inhibition of insulitis and prevention of diabetes in nonobese diabetic mice by blocking L-selectin and very late antigen 4 adhesion receptors

Yang, X D ; Karin, N ; Tisch, R ; Steinman, L ; Mcdevitt, H O

Proceedings of the National Academy of Sciences of the United States of America, 15 November 1993, Vol.90(22), pp.10494-8 [Peer Reviewed Journal]

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8
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N-acyl phenylalanine analogues as potent small molecule VLA-4 antagonists

Chen, L ; Tilley, J W ; Huang, T N ; Miklowski, D ; Trilles, R ; Guthrie, R W ; Luk, K ; Hanglow, A ; Rowan, K ; Schwinge, V ; Wolitzky, B

Bioorganic & medicinal chemistry letters, 17 April 2000, Vol.10(8), pp.725-7 [Peer Reviewed Journal]

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9
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The discovery of sulfonylated dipeptides as potent VLA-4 antagonists

Hagmann, W K ; Durette, P L ; Lanza, T ; Kevin, N J ; De Laszlo, S E ; Kopka, I E ; Young, D ; Magriotis, P A ; Li, B ; Lin, L S ; Yang, G ; Kamenecka, T ; Chang, L L ; Wilson, J ; Maccoss, M ; Mills, S G ; Van Riper, G ; Mccauley, E ; Egger, L A ; Kidambi, U ; Lyons, K ; Vincent, S ; Stearns, R ; Colletti, A ; Teffera, J ; Tong, S ; Fenyk-Melody, J ; Owens, K ; Levorse, D ; Kim, P ; Schmidt, J A ; Mumford, R A

Bioorganic & medicinal chemistry letters, 22 October 2001, Vol.11(20), pp.2709-13 [Peer Reviewed Journal]

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10
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N-acyl-L-phenylalanine derivatives as potent VLA-4 antagonists that mimic a cyclic peptide conformation

Chen, Li ; Tilley, Jefferson ; Trilles, Richard V ; Yun, Weiya ; Fry, David ; Cook, Charles ; Rowan, Karen ; Schwinge, Virginia ; Campbell, Robert

Bioorganic & medicinal chemistry letters, 21 January 2002, Vol.12(2), pp.137-40 [Peer Reviewed Journal]

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11
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Identification of potent and novel alpha4beta1 antagonists using in silico screening

Singh, Juswinder ; Van Vlijmen, Herman ; Liao, Yusheng ; Lee, Wen-Cherng ; Cornebise, Mark ; Harris, Mary ; Shu, I-Hsiang ; Gill, Alan ; Cuervo, Julio H ; Abraham, William M ; Adams, Steven P

Journal of medicinal chemistry, 04 July 2002, Vol.45(14), pp.2988-93 [Peer Reviewed Journal]

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12
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Diamine containing VLA-4 antagonists

Astles, P C ; Harris, N V ; Morley, A D

Bioorganic & medicinal chemistry, August 2001, Vol.9(8), pp.2195-202 [Peer Reviewed Journal]

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13
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Specific and dual antagonists of alpha(4)beta(1) and alpha(4)beta(7) integrins

Lin, Linus S ; Lanza, Thomas ; Mccauley, Ermenegilda ; Van Riper, Gail ; Kidambi, Usha ; Cao, Jin ; Egger, Linda A ; Mumford, Richard A ; Schmidt, John A ; Maccoss, Malcolm ; Hagmann, William K

Bioorganic & medicinal chemistry letters, 21 January 2002, Vol.12(2), pp.133-6 [Peer Reviewed Journal]

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14
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Squaric acid derivatives as VLA-4 integrin antagonists

Porter, John R ; Archibald, Sarah C ; Childs, Kirstie ; Critchley, David ; Head, John C ; Linsley, Janeen M ; Parton, Ted A H ; Robinson, Martyn K ; Shock, Anthony ; Taylor, Richard J ; Warrellow, Graham J ; Alexander, Rikki P ; Langham, Barry

Bioorganic & medicinal chemistry letters, 08 April 2002, Vol.12(7), pp.1051-4 [Peer Reviewed Journal]

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15
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Discovery and evaluation of potent, tyrosine-based alpha4beta1 integrin antagonists

Archibald, S C ; Head, J C ; Gozzard, N ; Howat, D W ; Parton, T A ; Porter, J R ; Robinson, M K ; Shock, A ; Warrellow, G J ; Abraham, W M

Bioorganic & medicinal chemistry letters, 01 May 2000, Vol.10(9), pp.997-9 [Peer Reviewed Journal]

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16
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Imide and lactam derivatives of N-benzylpyroglutamyl-L-phenylalanine as VCAM/VLA-4 antagonists

Tilley, J W ; Kaplan, G ; Rowan, K ; Schwinge, V ; Wolitzky, B

Bioorganic & medicinal chemistry letters, 08 January 2001, Vol.11(1), pp.1-4 [Peer Reviewed Journal]

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17
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Design and synthesis of potent and selective inhibitors of integrin VLA-4

Wattanasin, S ; Weidmann, B ; Roche, D ; Myers, S ; Xing, A ; Guo, Q ; Sabio, M ; Von Matt, P ; Hugo, R ; Maida, S ; Lake, P ; Weetall, M

Bioorganic & medicinal chemistry letters, 19 November 2001, Vol.11(22), pp.2955-8 [Peer Reviewed Journal]

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18
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N-benzylpyroglutamyl-L-phenylalanine derivatives as VCAM/VLA-4 antagonists

Chen, L ; Tilley, J W ; Guthrie, R W ; Mennona, F ; Huang, T N ; Kaplan, G ; Trilles, R ; Miklowski, D ; Huby, N ; Schwinge, V ; Wolitzky, B ; Rowan, K

Bioorganic & medicinal chemistry letters, 17 April 2000, Vol.10(8), pp.729-33 [Peer Reviewed Journal]

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19
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Carbacyclic peptide mimetics as VCAM-VLA-4 antagonists

Tilley, J ; Kaplan, G ; Fotouhi, N ; Wolitzky, B ; Rowan, K

Bioorganic & medicinal chemistry letters, 05 June 2000, Vol.10(11), pp.1163-5 [Peer Reviewed Journal]

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20
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Novel inhibitors of alpha 4 beta 1 integrin receptor interactions through library synthesis and screening

Souers, A J ; Virgilio, A A ; Schürer, S S ; Ellman, J A ; Kogan, T P ; West, H E ; Ankener, W ; Vanderslice, P

Bioorganic & medicinal chemistry letters, 08 September 1998, Vol.8(17), pp.2297-302 [Peer Reviewed Journal]

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21
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Cyclic thioether peptide mimetics as VCAM-VLA-4 antagonists

Fotouhi, N ; Joshi, P ; Tilley, J W ; Rowan, K ; Schwinge, V ; Wolitzky, B

Bioorganic & medicinal chemistry letters, 05 June 2000, Vol.10(11), pp.1167-9 [Peer Reviewed Journal]

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22
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Selective, tight-binding inhibitors of integrin alpha4beta1 that inhibit allergic airway responses

Lin, K C ; Ateeq, H S ; Hsiung, S H ; Chong, L T ; Zimmerman, C N ; Castro, A ; Lee, W C ; Hammond, C E ; Kalkunte, S ; Chen, L L ; Pepinsky, R B ; Leone, D R ; Sprague, A G ; Abraham, W M ; Gill, A ; Lobb, R R ; Adams, S P

Journal of medicinal chemistry, 11 March 1999, Vol.42(5), pp.920-34 [Peer Reviewed Journal]

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23
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1,25-Dihydroxyvitamin D3 suppresses the expression of the VCAM-1 receptor, VLA-4 in human leukemic HL-60 cells

Kaneko, A ; Suzuki, S ; Hara, M ; Mori, J ; Kumagai, M ; Yajima, H ; Yamashita, K ; Kakizawa, T ; Yamazaki, M ; Takeda, T ; Miyamoto, T ; Ichikawa, K ; Hashizume, K

Biochemical and biophysical research communications, 16 February 1999, Vol.255(2), pp.371-6 [Peer Reviewed Journal]

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24
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Interference of nonsteroidal antiinflammatory drugs with very late activation antigen 4/vascular cells adhesion molecule 1-mediated lymphocyte-endothelial cell adhesion

González-Alvaro, I ; Muñoz, C ; García-Vicuña, R ; Sabando, P ; Cabañas, C ; Sánchez-Madrid, F ; Díaz-González, F

Arthritis and rheumatism, September 1998, Vol.41(9), pp.1677-88 [Peer Reviewed Journal]

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25
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Safety, tolerability, and bioavailability of topical SAR 1118, a novel antagonist of lymphocyte function-associated antigen-1: a phase 1b study

Paskowitz, D M ; Nguyen, Q D ; Gehlbach, P ; Handa, J T ; Solomon, S ; Stark, W ; Shaikh, O ; Semba, C ; Gadek, T R ; Do, D V

Eye (London, England), July 2012, Vol.26(7), pp.944-9 [Peer Reviewed Journal]

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26
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Potent alpha 4 beta 1 peptide antagonists as potential anti-inflammatory agents

Jackson, D Y ; Quan, C ; Artis, D R ; Rawson, T ; Blackburn, B ; Struble, M ; Fitzgerald, G ; Chan, K ; Mullins, S ; Burnier, J P ; Fairbrother, W J ; Clark, K ; Berisini, M ; Chui, H ; Renz, M ; Jones, S ; Fong, S

Journal of medicinal chemistry, 10 October 1997, Vol.40(21), pp.3359-68 [Peer Reviewed Journal]

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27
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The design and synthesis of potent cyclic peptide VCAM-VLA-4 antagonists incorporating an achiral Asp-Pro mimetic

Fotouhi, N ; Joshi, P ; Fry, D ; Cook, C ; Tilley, J W ; Kaplan, G ; Hanglow, A ; Rowan, K ; Schwinge, V ; Wolitzky, B

Bioorganic & medicinal chemistry letters, 05 June 2000, Vol.10(11), pp.1171-3 [Peer Reviewed Journal]

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28
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Blockade of alpha 4 beta 1-integrin-fibronectin adhesive interactions prevents chronic allograft rejection in sensitized recipients

Coito, A J ; Korom, S ; Hancock, W W ; Kupiec-Weglinski, J W

Transplantation proceedings, June 1998, Vol.30(4), pp.939-40 [Peer Reviewed Journal]

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29
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LC/MS/MS plasma assay for the peptidomimetic VLA4 antagonist I and its major active metabolite II: for treatment of asthma by inhalation

Fisher, Alison L ; Depuy, Elizabeth ; Jayaraj, Andrew ; Raab, Conrad ; Braun, Matt ; Ellis-Hutchings, Michel ; Zhang, Jin ; Rogers, John D ; Musson, Donald G

Journal of pharmaceutical and biomedical analysis, 01 January 2002, Vol.27(1-2), pp.57-71 [Peer Reviewed Journal]

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30
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Melatonin reduces TNF-a induced expression of MAdCAM-1 via inhibition of NF-kappaB

Sasaki, Makoto ; Jordan, Paul ; Joh, Takashi ; Itoh, Makotoh ; Jenkins, Michael ; Pavlick, Kevin ; Minagar, Alireza ; Alexander, Steven J

BMC gastroenterology, 24 April 2002, Vol.2, pp.9 [Peer Reviewed Journal]

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31
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Potent cyclic peptide inhibitors of VLA-4 (alpha4beta1 integrin)-mediated cell adhesion. Discovery of compounds like cyclo(MePhe-Leu-Asp-Val-D-Arg-D-Arg) (ZD7349) compatible with depot formulation

Dutta, A S ; Gormley, J J ; Coath, M ; Hassall, L ; Hayward, C F ; Gellert, P R ; Kittlety, R S ; Alcock, P J ; Ferguson, R ; Halterman, T ; Jamieson, A ; Moors, J A ; Moores, J M ; Rees, A ; Wood, L J ; Reilly, C F ; Haworth, D

Journal of peptide science : an official publication of the European Peptide Society, August 2000, Vol.6(8), pp.398-412 [Peer Reviewed Journal]

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32
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Potent cyclic monomeric and dimeric peptide inhibitors of VLA-4 (alpha4beta1 integrin)-mediated cell adhesion based on the Ile-Leu-Asp-Val tetrapeptide

Dutta, A S ; Crowther, M ; Gormley, J J ; Hassall, L ; Hayward, C F ; Gellert, P R ; Kittlety, R S ; Alcock, P J ; Jamieson, A ; Moores, J M ; Rees, A ; Wood, L J ; Reilly, C F ; Haworth, D

Journal of peptide science : an official publication of the European Peptide Society, July 2000, Vol.6(7), pp.321-41 [Peer Reviewed Journal]

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33
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Inhibition of TNF-alpha-induced sickle RBC retention in retina by a VLA-4 antagonist

Lutty, G A ; Taomoto, M ; Cao, J ; Mcleod, D S ; Vanderslice, P ; Mcintyre, B W ; Fabry, M E ; Nagel, R L

Investigative ophthalmology & visual science, May 2001, Vol.42(6), pp.1349-55 [Peer Reviewed Journal]

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34
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Very late antigen 4 (VLA4) antagonists as anti-inflammatory agents

Lin, K C ; Castro, A C

Current opinion in chemical biology, August 1998, Vol.2(4), pp.453-7 [Peer Reviewed Journal]

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35
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Anti-inflammatory activity of c(ILDV-NH(CH2)5CO), a novel, selective, cyclic peptide inhibitor of VLA-4-mediated cell adhesion

Haworth, D ; Rees, A ; Alcock, P J ; Wood, L J ; Dutta, A S ; Gormley, J J ; Jones, H B ; Jamieson, A ; Reilly, C F

British journal of pharmacology, April 1999, Vol.126(8), pp.1751-60 [Peer Reviewed Journal]

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36
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Urokinase-type plasminogen activator inhibits alpha 4 beta 1 integrin-mediated T lymphocyte adhesion to fibronectin independently of its catalytic activity

Olivier, P ; Bieler, G ; Müller, K M ; Hauzenberger, D ; Rüegg, C

European journal of immunology, October 1999, Vol.29(10), pp.3196-209 [Peer Reviewed Journal]

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