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Optimization of (2,3-dihydro-1-benzofuran-3-yl)acetic acids: discovery of a non-free fatty acid-like, highly bioavailable G protein-coupled receptor 40/free fatty acid receptor 1 agonist as a glucose-dependent insulinotropic agent

Negoro, Nobuyuki ; Sasaki, Shinobu ; Mikami, Satoshi ; Ito, Masahiro ; Tsujihata, Yoshiyuki ; Ito, Ryo ; Suzuki, Masami ; Takeuchi, Koji ; Suzuki, Nobuhiro ; Miyazaki, Junichi ; Santou, Takashi ; Odani, Tomoyuki ; Kanzaki, Naoyuki ; Funami, Miyuki ; Morohashi, Akio ; Nonaka, Masami ; Matsunaga, Shinichiro ; Yasuma, Tsuneo ; Momose, Yu

Journal of medicinal chemistry, 26 April 2012, Vol.55(8), pp.3960-74 [Peer Reviewed Journal]

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