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10 Results  for Everything (Includes Articles)

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Quality by design (QbD) of amide isosteres: 5,5-Disubstituted isoxazolines as potent CRTh2 antagonists with favorable pharmacokinetic and drug-like properties

Xiao, Dong ; Zhu, Xiaohong ; Yu, Younong ; Shao, Ning ; Wu, Jie ; Mccormick, Kevin D ; Dhondi, Pawan ; Qin, Jun ; Mazzola, Robert ; Tang, Haiqun ; Rao, Ashwin ; Siliphaivanh, Phieng ; Qiu, Hongchen ; Yang, Xiaoxin ; Rivelli, Maria ; Garlisi, Charles G ; Eckel, Steve ; Mukhopadhyay, Gitali ; Correll, Craig ; Rindgen, Diane

Bioorganic & Medicinal Chemistry Letters, 15 March 2014, Vol.24(6), pp.1615-1620 [Peer Reviewed Journal]

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Discovery of novel BTK inhibitors with carboxylic acids

Gao, Xiaolei ; Wang, James ; Liu, Jian ; Guiadeen, Deodial ; Krikorian, Arto ; Boga, Sobhana Babu ; Alhassan, Abdul-Basit ; Selyutin, Oleg ; Yu, Wensheng ; Yu, Younong ; Anand, Rajan ; Liu, Shilan ; Yang, Chundao ; Wu, Hao ; Cai, Jiaqiang ; Cooper, Alan ; Zhu, Hugh ; Maloney, Kevin ; Gao, Ying-Duo ; Fischmann, Thierry O

Bioorganic & Medicinal Chemistry Letters, 15 March 2017, Vol.27(6), pp.1471-1477 [Peer Reviewed Journal]

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Discovery of 3-morpholino-imidazole[1,5-a]pyrazine BTK inhibitors for rheumatoid arthritis

Boga, Sobhana Babu ; Alhassan, Abdul-Basit ; Liu, Jian ; Guiadeen, Deodial ; Krikorian, Arto ; Gao, Xiaolei ; Wang, James ; Yu, Younong ; Anand, Rajan ; Liu, Shilan ; Yang, Chundao ; Wu, Hao ; Cai, Jiaqiang ; Zhu, Hugh ; Desai, Jagdish ; Maloney, Kevin ; Gao, Ying-Duo ; Fischmann, Thierry O ; Presland, Jeremy ; Mansueto, My

Bioorganic & Medicinal Chemistry Letters, 15 August 2017, Vol.27(16), pp.3939-3943 [Peer Reviewed Journal]

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Fluoroalkyl α side chain containing 3,4-diamino-cyclobutenediones as potent and orally bioavailable CXCR2–CXCR1 dual antagonists

Biju, Purakkattle ; Taveras, Arthur G ; Dwyer, Michael P ; Yu, Younong ; Chao, Jianhua ; Hipkin, R. William ; Fan, Xuedong ; Rindgen, Diane ; Fine, Jay ; Lundell, Daniel

Bioorganic & Medicinal Chemistry Letters, 2009, Vol.19(5), pp.1431-1433 [Peer Reviewed Journal]

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3,4-Diamino-1,2,5-thiadiazole as potent and selective CXCR2 antagonists

Biju, Purakkattle ; Taveras, Arthur G ; Yu, Younong ; Zheng, Junying ; Hipkin, R. William ; Fossetta, James ; Fan, Xuedong ; Fine, Jay ; Lundell, Daniel

Bioorganic & Medicinal Chemistry Letters, 2009, Vol.19(5), pp.1434-1437 [Peer Reviewed Journal]

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Diaminocyclobutenediones as potent and orally bioavailable CXCR2 receptor antagonists: SAR in the phenolic amide region

Aki, Cynthia ; Chao, Jianping ; Ferreira, Johan A ; Dwyer, Michael P ; Yu, Younong ; Chao, Jianhua ; Merritt, Robert J ; Lai, Gaifa ; Wu, Minglang ; Hipkin, R. William ; Fan, Xuedong ; Gonsiorek, Waldemar ; Fosseta, James ; Rindgen, Diane ; Fine, Jay ; Lundell, Daniel ; Taveras, Arthur G ; Biju, Purakkattle

Bioorganic & Medicinal Chemistry Letters, 01 August 2009, Vol.19(15), pp.4446-4449 [Peer Reviewed Journal]

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3,4-Diamino-2,5-thiadiazole-1-oxides as potent CXCR2/CXCR1 antagonists

Biju, Purakkattle ; Taveras, Arthur ; Yu, Younong ; Zheng, Junying ; Chao, Jianhua ; Rindgen, Diane ; Jakway, James ; Hipkin, R. William ; Fossetta, James ; Fan, Xuedong ; Fine, Jay ; Qiu, Hongchen ; Merritt, J. Robert ; Baldwin, John J

Bioorganic & Medicinal Chemistry Letters, 2008, Vol.18(1), pp.228-231 [Peer Reviewed Journal]

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C(4)-alkyl substituted furanyl cyclobutenediones as potent, orally bioavailable CXCR2 and CXCR1 receptor antagonists

Chao, Jianhua ; Taveras, Arthur G ; Chao, Jianping ; Aki, Cynthia ; Dwyer, Michael ; Yu, Younong ; Purakkattle, Biju ; Rindgen, Diane ; Jakway, James ; Hipkin, William ; Fosetta, James ; Fan, Xuedong ; Lundell, Daniel ; Fine, Jay ; Minnicozzi, Michael ; Phillips, Jonathan ; Merritt, J. Robert

Bioorganic & Medicinal Chemistry Letters, 2007, Vol.17(13), pp.3778-3783 [Peer Reviewed Journal]

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Synthesis and structure–activity relationships of heteroaryl substituted-3,4-diamino-3-cyclobut-3-ene-1,2-dione CXCR2/CXCR1 receptor antagonists

Yu, Younong ; Dwyer, Michael P ; Chao, Jianping ; Aki, Cynthia ; Chao, Jianhua ; Purakkattle, Biju ; Rindgen, Diane ; Bond, Richard ; Mayer-Ezel, Rosemary ; Jakway, James ; Qiu, Hongchen ; Hipkin, R. William ; Fossetta, James ; Gonsiorek, Waldemar ; Bian, Hong ; Fan, Xuedong ; Terminelli, Carol ; Fine, Jay ; Lundell, Daniel ; Merritt, J. Robert

Bioorganic & Medicinal Chemistry Letters, 2008, Vol.18(4), pp.1318-1322 [Peer Reviewed Journal]

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Discovery of ethyl ketone-based HDACs 1, 2, and 3 selective inhibitors for HIV latency reactivation

Yu, Wensheng ; Liu, Jian ; Yu, Younong ; Zhang, Vivian ; Clausen, Dane ; Kelly, Joseph ; Wolkenberg, Scott ; Beshore, Douglas ; Duffy, Joseph L ; Chung, Christine C ; Myers, Robert W ; Klein, Daniel J ; Fells, James ; Holloway, Kate ; Wu, Jin ; Wu, Guoxin ; Howell, Bonnie J ; Barnard, Richard J.O ; Kozlowski, Joseph

Bioorganic & Medicinal Chemistry Letters [Peer Reviewed Journal]

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