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Effects of VLA‐4 antagonists in rat whole embryo culture

Spence, Stan ; Vetter, Christine ; Hagmann, William K. ; Van Riper, Gail ; Williams, Hollis ; Mumford, Richard A. ; Lanza, Thomas J. ; Lin, Linus S. ; Schmidt, John A.

Teratology, January 2002, Vol.65(1), pp.26-37

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The design and synthesis of potent, selective benzodiazepine sulfonamide bombesin receptor subtype 3 (BRS-3) agonists with an increased barrier of atropisomerization

Chobanian, Harry R ; Guo, Yan ; Liu, Ping ; Lanza, Thomas J ; Chioda, Marc ; Chang, Linda ; Kelly, Theresa M ; Kan, Yanqing ; Palyha, Oksana ; Guan, Xiao-Ming ; Marsh, Donald J ; Metzger, Joseph M ; Raustad, Katie ; Wang, Sheng-Ping ; Strack, Alison M ; Gorski, Judith N ; Miller, Randy ; Pang, Jianmei ; Lyons, Kathy ; Dragovic, Jasminka ; Ning, Jian G ; Schafer, Wes A ; Welch, Christopher J ; Gong, Xiaoyi ; Gao, Ying-Duo ; Hornak, Viktor ; Reitman, Marc L ; Nargund, Ravi P ; Lin, Linus S

Bioorganic & Medicinal Chemistry, 01 May 2012, Vol.20(9), pp.2845-2849 [Peer Reviewed Journal]

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A highly active catalyst system for the heteroarylation of acetone

Liu, Ping ; Lanza, Thomas J ; Jewell, James P ; Jones, Carrie P ; Hagmann, William K ; Lin, Linus S

Tetrahedron Letters, 2003, Vol.44(49), pp.8869-8871 [Peer Reviewed Journal]

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Synthesis and cannabinoid-1 receptor binding affinity of conformationally constrained analogs of taranabant

Kopka, Ihor E ; Lin, Linus S ; Jewell, James P ; Lanza, Thomas J ; Fong, Tung M ; Shen, Chun-Pyn ; Lao, Zhege J ; Ha, Sookhee ; Castonguay, Laurie G ; Van Der Ploeg, Lex ; Goulet, Mark T ; Hagmann, William K

Bioorganic & Medicinal Chemistry Letters, 2010, Vol.20(16), pp.4757-4761 [Peer Reviewed Journal]

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Discovery of MK-7725, A Potent, Selective Bombesin Receptor Subtype-3 Agonist for the Treatment of Obesity

Chobanian, Harry R ; Guo, Yan ; Liu, Ping ; Chioda, Marc ; Lanza, Thomas J ; Chang, Linda ; Kelly, Theresa M ; Kan, Yanqing ; Palyha, Oksana ; Guan, Xiao-Ming ; Marsh, Donald J ; Metzger, Joseph M ; Gorski, Judith N ; Raustad, Kate ; Wang, Sheng-Ping ; Strack, Alison M ; Miller, Randy ; Pang, Jianmei ; Madeira, Maria ; Lyons, Kathy ; Dragovic, Jasminka ; Reitman, Marc L ; Nargund, Ravi P ; Lin, Linus S

ACS medicinal chemistry letters, 08 March 2012, Vol.3(3), pp.252-6 [Peer Reviewed Journal]

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Effects of mutations at conserved TM II residues on ligand binding and activation of mouse 5-HT 6 receptor

Zhang, Jiaping ; Shen, Chun-Pyn ; Xiao, Jing C ; Lanza, Thomas J ; Lin, Linus S ; Francis, Barbara E ; Fong, Tung M ; Chen, Richard Z

European Journal of Pharmacology, 2006, Vol.534(1), pp.77-82 [Peer Reviewed Journal]

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Discovery of benzodiazepine sulfonamide-based bombesin receptor subtype 3 agonists and their unusual chirality

Liu, Ping ; Lanza, Thomas J ; Chioda, Marc ; Jones, Carrie ; Chobanian, Harry R ; Guo, Yan ; Chang, Linda ; Kelly, Theresa M ; Kan, Yanqing ; Palyha, Oksana ; Guan, Xiao-Ming ; Marsh, Donald J ; Metzger, Joseph M ; Ramsay, Katie ; Wang, Sheng-Ping ; Strack, Alison M ; Miller, Randy ; Pang, Jianmei ; Lyons, Kathy ; Dragovic, Jasminka ; Ning, Jian G ; Schafer, Wes A ; Welch, Christopher J ; Gong, Xiaoyi ; Gao, Ying-Duo ; Hornak, Viktor ; Ball, Richard G ; Tsou, Nancy ; Reitman, Marc L ; Wyvratt, Matthew J ; Nargund, Ravi P ; Lin, Linus S

ACS medicinal chemistry letters, 08 December 2011, Vol.2(12), pp.933-7 [Peer Reviewed Journal]

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Discovery of MK-4409, a Novel Oxazole FAAH Inhibitor for the Treatment of Inflammatory and Neuropathic Pain

Chobanian, Harry R ; Guo, Yan ; Liu, Ping ; Chioda, Marc D ; Fung, Selena ; Lanza, Thomas J ; Chang, Linda ; Bakshi, Raman K ; Dellureficio, James P ; Hong, Qingmei ; Mclaughlin, Mark ; Belyk, Kevin M ; Krska, Shane W ; Makarewicz, Amanda K ; Martel, Elliot J ; Leone, Joseph F ; Frey, Lisa ; Karanam, Bindhu ; Madeira, Maria ; Alvaro, Raul ; Shuman, Joyce ; Salituro, Gino ; Terebetski, Jenna L ; Jochnowitz, Nina ; Mistry, Shruti ; Mcgowan, Erin ; Hajdu, Richard ; Rosenbach, Mark ; Abbadie, Catherine ; Alexander, Jessica P ; Shiao, Lin-Lin ; Sullivan, Kathleen M ; Nargund, Ravi P ; Wyvratt, Matthew J ; Lin, Linus S ; Devita, Robert J

ACS medicinal chemistry letters, 12 June 2014, Vol.5(6), pp.717-21 [Peer Reviewed Journal]

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Discovery of N-{(1S,2S)-2-(3-cyanophenyl)- 3-4-(2-18Ffluoroethoxy)phenyl-1-methylpropyl}- 2-methyl-2-(5-methylpyridin-2-yl)oxypropanamide, a cannabinoid-1 receptor positron emission tomography tracer suitable for clinical use

Liu, Ping ; Lin, Linus S ; Hamill, Terence G ; Jewell, James P ; Lanza, Thomas J ; Gibson, Raymond E ; Krause, Stephen M ; Ryan, Christine ; Eng, Waisi ; Sanabria, Sandra ; Tong, Xinchun ; Wang, Junying ; Levorse, Dorothy A ; Owens, Karen A ; Fong, Tung M ; Shen, Chun-Pyn ; Lao, Julie ; Kumar, Sanjeev ; Yin, Wenji ; Payack, Joseph F ; Springfield, Shawn A ; Hargreaves, Richard ; Burns, H Donald ; Goulet, Mark T ; Hagmann, William K

Journal of medicinal chemistry, 26 July 2007, Vol.50(15), pp.3427-30 [Peer Reviewed Journal]

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Discovery of N-(1S,2S)-3-(4-Chlorophenyl)-2- (3-cyanophenyl)-1-methylpropyl-2-methyl-2- {5-(trifluoromethyl)pyridin-2-yloxy}propanamide (MK-0364), a novel, acyclic cannabinoid-1 receptor inverse agonist for the treatment of obesity

Lin, Linus S ; Lanza, Thomas J ; Jewell, James P ; Liu, Ping ; Shah, Shrenik K ; Qi, Hongbo ; Tong, Xinchun ; Wang, Junying ; Xu, Suoyu S ; Fong, Tung M ; Shen, Chun-Pyn ; Lao, Julie ; Xiao, Jing Chen ; Shearman, Lauren P ; Stribling, D Sloan ; Rosko, Kimberly ; Strack, Alison ; Marsh, Donald J ; Feng, Yue ; Kumar, Sanjeev ; Samuel, Koppara ; Yin, Wenji ; Van Der Ploeg, Lex H T ; Goulet, Mark T ; Hagmann, William K

Journal of medicinal chemistry, 28 December 2006, Vol.49(26), pp.7584-7 [Peer Reviewed Journal]

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A small molecule alpha4beta1/alpha4beta7 antagonist differentiates between the low-affinity states of alpha4beta1 and alpha4beta7: characterization of divalent cation dependence

Egger, Linda A ; Cao, Jin ; Mccallum, Christine ; Kidambi, Usha ; Van Riper, Gail ; Mccauley, Ermengilda ; Mumford, Richard A ; Lanza, Thomas J ; Lin, Linus S ; De Laszlo, Stephen E ; Young, David N ; Yang, Ginger ; Dean, Dennis C ; Raab, Conrad E ; Wallace, Mike A ; Jones, Allen N ; Hagmann, William K ; Schmidt, John A ; Pepinsky, R Blake ; Scott, Daniel M ; Lee, Wen-Cherng ; Cornebise, Mark A ; Detmers, Patricia A

The Journal of pharmacology and experimental therapeutics, September 2003, Vol.306(3), pp.903-13 [Peer Reviewed Journal]

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Antiobesity efficacy of a novel cannabinoid-1 receptor inverse agonist, N-(1S,2S)-3-(4-chlorophenyl)-2-(3-cyanophenyl)-1-methylpropyl-2-methyl-2-5-(trifluoromethyl)pyridin-2-yloxypropanamide (MK-0364), in rodents

Fong, Tung M ; Guan, Xiao-Ming ; Marsh, Donald J ; Shen, Chun-Pyn ; Stribling, D Sloan ; Rosko, Kim M ; Lao, Julie ; Yu, Hong ; Feng, Yue ; Xiao, Jing C ; Van Der Ploeg, Lex H T ; Goulet, Mark T ; Hagmann, Williams K ; Lin, Linus S ; Lanza, Thomas J ; Jewell, James P ; Liu, Ping ; Shah, Shrenik K ; Qi, Hongbo ; Tong, Xinchun ; Wang, Junying ; Xu, Suoyu S ; Francis, Barbara ; Strack, Alison M ; Macintyre, D Euan ; Shearman, Lauren P

The Journal of pharmacology and experimental therapeutics, June 2007, Vol.321(3), pp.1013-22 [Peer Reviewed Journal]

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Bioisosteric replacement of anilide with benzoxazole: potent and orally bioavailable antagonists of VLA-4

Lin, Linus S ; Lanza, Thomas J ; Castonguay, Laurie A ; Kamenecka, Theodore ; Mccauley, Ermenegilda ; Van Riper, Gail ; Egger, Linda A ; Mumford, Richard A ; Tong, Xinchun ; Maccoss, Malcolm ; Schmidt, John A ; Hagmann, William K

Bioorganic & Medicinal Chemistry Letters, 03 May 2004, Vol.14(9), pp.2331-2334 [Peer Reviewed Journal]

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Substituted acyclic sulfonamides as human cannabinoid-1 receptor inverse agonists

Armstrong, Helen E ; Galka, Amy ; Lin, Linus S ; Lanza, Thomas J ; Jewell, James P ; Shah, Shrenik K ; Guthikonda, Ravi ; Truong, Quang ; Chang, Linda L ; Quaker, Grace ; Colandrea, Vincent J ; Tong, Xinchun ; Wang, Junying ; Xu, Sherry ; Fong, Tung M ; Shen, Chun-Pyn ; Lao, Julie ; Chen, Jing ; Shearman, Lauren P ; Stribling, D. Sloan ; Rosko, Kimberly ; Strack, Alison ; Ha, Sookhee ; Der Ploeg, Lex Van ; Goulet, Mark T ; Hagmann, William K

Bioorganic & Medicinal Chemistry Letters, 2007, Vol.17(8), pp.2184-2187 [Peer Reviewed Journal]

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