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9 Results  for Everything (Includes Articles)

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Irreversible protein kinase inhibitors: balancing the benefits and risks

Barf, Tjeerd ; Kaptein, Allard

Journal of medicinal chemistry, 26 July 2012, Vol.55(14), pp.6243-62 [Peer Reviewed Journal]

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In vivo knockdown of TAK1 accelerates bone marrow proliferation/differentiation and induces systemic inflammation

Vink, Paul M ; Smout, Wendy M ; Driessen-Engels, Lilian J ; De Bruin, Alex M ; Delsing, Dianne ; Krajnc-Franken, Magda A ; Jansen, Aswin J ; Rovers, Eric F ; Van Puijenbroek, André A ; Kaptein, Allard ; Nolte, Martijn A ; Garritsen, Anja ; Van Eenennaam, Hans

PloS one, 2013, Vol.8(3), pp.e57348 [Peer Reviewed Journal]

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Preclinical Evaluation of the Novel BTK Inhibitor Acalabrutinib in Canine Models of B-Cell Non-Hodgkin Lymphoma

Harrington, Bonnie K ; Gardner, Heather L ; Izumi, Raquel ; Hamdy, Ahmed ; Rothbaum, Wayne ; Coombes, Kevin R ; Covey, Todd ; Kaptein, Allard ; Gulrajani, Michael ; Van Lith, Bart ; Krejsa, Cecile ; Coss, Christopher C ; Russell, Duncan S ; Zhang, Xiaoli ; Urie, Bridget K ; London, Cheryl A ; Byrd, John C ; Johnson, Amy J ; Kisseberth, William C Richards, Kristy L. (editor)

PLoS ONE, 2016, Vol.11(7) [Peer Reviewed Journal]

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The Bruton Tyrosine Kinase (BTK) Inhibitor Acalabrutinib Demonstrates Potent On-Target Effects and Efficacy in Two Mouse Models of Chronic Lymphocytic Leukemia

Herman, Sarah E M ; Montraveta, Arnau ; Niemann, Carsten U ; Mora-Jensen, Helena ; Gulrajani, Michael ; Krantz, Fanny ; Mantel, Rose ; Smith, Lisa L ; Mcclanahan, Fabienne ; Harrington, Bonnie K ; Colomer, Dolors ; Covey, Todd ; Byrd, John C ; Izumi, Raquel ; Kaptein, Allard ; Ulrich, Roger ; Johnson, Amy J ; Lannutti, Brian J ; Wiestner, Adrian ; Woyach

Clinical cancer research : an official journal of the American Association for Cancer Research, 01 June 2017, Vol.23(11), pp.2831-2841 [Peer Reviewed Journal]

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Novel ATP competitive MK2 inhibitors with potent biochemical and cell-based activity throughout the series

Oubrie, Arthur ; Kaptein, Allard ; de Zwart, Edwin ; Hoogenboom, Niels ; Goorden, Rianne ; van de Kar, Bas ; van Hoek, Maaike ; de Kimpe, Vera ; van Der Heijden, Ruud ; Borsboom, Judith ; Kazemier, Bert ; de Roos, Jeroen ; Scheffers, Michiel ; Lommerse, Jos ; Schultz-Fademrecht, Carsten ; Barf, Tjeerd

Bioorganic & Medicinal Chemistry Letters, 01 January 2012, Vol.22(1), pp.613-618 [Peer Reviewed Journal]

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Acalabrutinib (ACP-196): A Covalent Bruton Tyrosine Kinase Inhibitor with a Differentiated Selectivity and In Vivo Potency Profile

Barf, Tjeerd ; Covey, Todd ; Izumi, Raquel ; Van De Kar, Bas ; Gulrajani, Michael ; Van Lith, Bart ; Van Hoek, Maaike ; De Zwart, Edwin ; Mittag, Diana ; Demont, Dennis ; Verkaik, Saskia ; Krantz, Fanny ; Pearson, Paul G ; Ulrich, Roger ; Kaptein, Allard

The Journal of pharmacology and experimental therapeutics, November 2017, Vol.363(2), pp.240-252 [Peer Reviewed Journal]

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Discovery of 8-Amino-imidazo[1,5- a ]pyrazines as Reversible BTK Inhibitors for the Treatment of Rheumatoid Arthritis

Liu, Jian ; Guiadeen, Deodial ; Krikorian, Arto ; Gao, Xiaolei ; Wang, James ; Boga, Sobhana Babu ; Alhassan, Abdul-Basit ; Yu, Younong ; Vaccaro, Henry ; Liu, Shilan ; Yang, Chundao ; Wu, Hao ; Cooper, Alan ; de Man, Jos ; Kaptein, Allard ; Maloney, Kevin ; Hornak, Viktor ; Gao, Ying-Duo ; Fischmann, Thierry O ; Raaijmakers, Hans ; Vu-Pham, Diep ; Presland, Jeremy ; Mansueto, My ; Xu, Zangwei ; Leccese, Erica ; Zhang-Hoover, Jie ; Knemeyer, Ian ; Garlisi, Charles G ; Bays, Nathan ; Stivers, Peter ; Brandish, Philip E ; Hicks, Alexandra ; Kim, Ronald ; Kozlowski, Joseph A Argonne National Lab. (Anl), Argonne, Il (United States). Advanced Photon Source (APS) (Corporate Author)

ACS Medicinal Chemistry Letters, 11 February 2016, Vol.7(2) [Peer Reviewed Journal]

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Acalabrutinib (ACP-196) in Relapsed Chronic Lymphocytic Leukemia

Byrd, John C ; Harrington, Bonnie ; O'Brien, Susan ; Jones, Jeffrey A ; Schuh, Anna ; Devereux, Steve ; Chaves, Jorge ; Wierda, William G ; Awan, Farrukh T ; Brown, Jennifer R ; Hillmen, Peter ; Stephens, Deborah M ; Ghia, Paolo ; Barrientos, Jacqueline C ; Pagel, John M ; Woyach, Jennifer ; Johnson, Dave ; Huang, Jane ; Wang

The New England journal of medicine, 28 January 2016, Vol.374(4), pp.323-32 [Peer Reviewed Journal]

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Potency and Selectivity of BTK Inhibitors in Clinical Development for B-Cell Malignancies

Kaptein, Allard ; de Bruin, Gerjan ; Hoek, Maaike Emmelot-van ; van de Kar, Bas ; de Jong, Anouk ; Gulrajani, Michael ; Demont, Dennis ; Covey, Todd ; Mittag, Diana ; Barf, Tjeerd

Clinical Lymphoma, Myeloma and Leukemia, September 2019, Vol.19, pp.S316-S317 [Peer Reviewed Journal]

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