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Results 51 - 87 of 87  for Everything (Includes Articles)

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51
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A rational utilization of high-throughput screening affords selective, orally bioavailable 1-benzyl-3-carboxyazetidine sphingosine-1-phosphate-1 receptor agonists

Hale, Jeffrey J ; Lynch, Christopher L ; Neway, William ; Mills, Sander G ; Hajdu, Richard ; Keohane, Carol Ann ; Rosenbach, Mark J ; Milligan, James A ; Shei, Gan-Ju ; Parent, Stephen A ; Chrebet, Gary ; Bergstrom, James ; Card, Deborah ; Ferrer, Marc ; Hodder, Peter ; Strulovici, Berta ; Rosen, Hugh ; Mandala, Suzanne

Journal of medicinal chemistry, 30 December 2004, Vol.47(27), pp.6662-5 [Peer Reviewed Journal]

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52
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1,3,4-Trisubstituted pyrrolidine CCR5 receptor antagonists. Part 3: polar functionality and its effect on anti-HIV-1 activity

Hale, Jeffrey J ; Budhu, Richard J ; Mills, Sander G ; Maccoss, Malcolm ; Gould, Sandra L ; Demartino, Julie A ; Springer, Martin S ; Siciliano, Salvatore J ; Malkowitz, Lorraine ; Schleif, William A ; Hazuda, Daria ; Miller, Michael ; Kessler, Joseph ; Danzeisen, Renee ; Holmes, Karen ; Lineberger, Janet ; Carella, Anthony ; Carver, Gwen ; Emini, Emilio A

Bioorganic & Medicinal Chemistry Letters, 21 October 2002, Vol.12(20), pp.2997-3000 [Peer Reviewed Journal]

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53
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Design and synthesis of a new class of malonyl-CoA decarboxylase inhibitors with anti-obesity and anti-diabetic activities

Tang, Haifeng ; Yan, Yan ; Feng, Zhe ; de Jesus, Reynalda K. ; Yang, Lihu ; Levorse, Dorothy A. ; Owens, Karen A. ; Akiyama, Taro E. ; Bergeron, Raynald ; Castriota, Gino A. ; Doebber, Thomas W. ; Ellsworth, Kenneth P. ; Lassman, Michael E. ; Li, Cai ; Wu, Margaret S. ; Zhang, Bei B. ; Chapman, Kevin T. ; Mills, Sander G. ; Berger, Joel P. ; Pasternak, Alexander

Bioorganic & Medicinal Chemistry Letters, 2010, Vol.20(20), pp.6088-6092 [Peer Reviewed Journal]

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54
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Phosphinic acid inhibitors of matrix metalloproteinases

Caldwell, Charles G. ; Sahoo, Soumya P. ; Polo, Scott A. ; Eversole, Randall R. ; Lanza, Thomas J. ; Mills, Sander G. ; Niedzwiecki, Lisa M. ; Izquierdo-Martin, Maria ; Chang, Benedict C. ; Harrison, Richard K. ; Kuo, David W. ; Lin, T.-Y. ; Stein, Ross L. ; Durette, Philippe L. ; Hagmann, William K.

Bioorganic & Medicinal Chemistry Letters, 1996, Vol.6(3), pp.323-328 [Peer Reviewed Journal]

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55
2( S )-((3,5-Bis(trifluoromethyl)benzyl)oxy)-3( S )-phenyl-4-((3-oxo-1,2,4-triazol- 5-yl)methyl)morpholine ( 1 ):  A Potent, Orally Active, Morpholine-Based Human Neurokinin-1 Receptor Antagonist
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2( S )-((3,5-Bis(trifluoromethyl)benzyl)oxy)-3( S )-phenyl-4-((3-oxo-1,2,4-triazol- 5-yl)methyl)morpholine ( 1 ):  A Potent, Orally Active, Morpholine-Based Human Neurokinin-1 Receptor Antagonist

Hale, Jeffrey J. ; Mills, Sander G. ; Maccoss, Malcolm ; Shah, Shrenik K. ; Qi, Hongbo ; Mathre, David J. ; Cascieri, Margaret A. ; Sadowski, Sharon ; Strader, Catherine D. ; Macintyre, D. Euan ; Metzger, Joseph M.

Journal of Medicinal Chemistry, 01/1996, Vol.39(9), pp.1760-1762 [Peer Reviewed Journal]

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56
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CCR5 antagonists: 3-(pyrrolidin-1-yl)propionic acid analogues with potent anti-HIV activity

Lynch, Christopher L ; Hale, Jeffrey J ; Budhu, Richard J ; Gentry, Amy L ; Finke, Paul E ; Caldwell, Charles G ; Mills, Sander G ; Maccoss, Malcolm ; Shen, Dong-Ming ; Chapman, Kevin T ; Malkowitz, Lorraine ; Springer, Martin S ; Gould, Sandra L ; Demartino, Julie A ; Siciliano, Salvatore J ; Cascieri, Margaret A ; Carella, Anthony ; Carver, Gwen ; Holmes, Karen ; Schleif, William A ; Danzeisen, Renee ; Hazuda, Daria ; Kessler, Joseph ; Lineberger, Janet ; Miller, Michael ; Emini, Emilio

Organic letters, 10 July 2003, Vol.5(14), pp.2473-5 [Peer Reviewed Journal]

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57
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Characterization of a novel and selective cannabinoid CB 1 receptor inverse agonist, Imidazole 24b, in rodents

Shearman, Lauren P. ; Stribling, D. Sloan ; Camacho, Ramon E. ; Rosko, Kimberly M. ; Wang, Junying ; Tong, Sharon ; Feng, Yue ; Marsh, Donald J. ; Yu, Hong ; Guan, Xiaoming ; Spann, Stephanie K. ; Macneil, Douglas J. ; Fong, Tung M. ; Metzger, Joseph M. ; Goulet, Mark T. ; Hagmann, William K. ; Plummer, Christopher W. ; Finke, Paul E. ; Mills, Sander G. ; Shah, Shrenik K. ; Truong, Quang ; Van Der Ploeg, L.H.T. ; Macintyre, D. Euan ; Strack, Alison M.

European Journal of Pharmacology, 2008, Vol.579(1), pp.215-224 [Peer Reviewed Journal]

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58
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Cyclopentane-based human NK1 antagonists. Part 2: Development of potent, orally active, water-soluble derivatives

Meurer, Laura C. ; Finke, Paul E. ; Owens, Karen A. ; Tsou, Nancy N. ; Ball, Richard G. ; Mills, Sander G. ; Maccoss, Malcolm ; Sadowski, Sharon ; Cascieri, Margaret A. ; Tsao, Kwei-Lan ; Chicchi, Gary G. ; Egger, Linda A. ; Luell, Silvi ; Metzger, Joseph M. ; Macintyre, D. Euan ; Rupniak, Nadia M.J. ; Williams, Angela R. ; Hargreaves, Richard J.

Bioorganic & Medicinal Chemistry Letters, 2006, Vol.16(17), pp.4504-4511 [Peer Reviewed Journal]

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59
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Potent 1,3,4-trisubstituted pyrrolidine CCR5 receptor antagonists: effects of fused heterocycles on antiviral activity and pharmacokinetic properties

Kim, Dooseop ; Wang, Liping ; Hale, Jeffrey J. ; Lynch, Christopher L. ; Budhu, Richard J. ; Maccoss, Malcolm ; Mills, Sander G. ; Malkowitz, Lorraine ; Gould, Sandra L. ; Demartino, Julie A. ; Springer, Martin S. ; Hazuda, Daria ; Miller, Michael ; Kessler, Joseph ; Hrin, Renee C. ; Carver, Gwen ; Carella, Anthony ; Henry, Karen ; Lineberger, Janet ; Schleif, William A. ; Emini, Emilio A.

Bioorganic & Medicinal Chemistry Letters, 2005, Vol.15(8), pp.2129-2134 [Peer Reviewed Journal]

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60
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Discovery of potent 3,5-diphenyl-1,2,4-oxadiazole sphingosine-1-phosphate-1 (S1P1) receptor agonists with exceptional selectivity against S1P2 and S1P3

Li, Zhen ; Chen, Weirong ; Hale, Jeffrey J ; Lynch, Christopher L ; Mills, Sander G ; Hajdu, Richard ; Keohane, Carol Ann ; Rosenbach, Mark J ; Milligan, James A ; Shei, Gan-Ju ; Chrebet, Gary ; Parent, Stephen A ; Bergstrom, James ; Card, Deborah ; Forrest, Michael ; Quackenbush, Elizabeth J ; Wickham, L Alexandra ; Vargas, Hugo ; Evans, Rose M ; Rosen, Hugh ; Mandala, Suzanne

Journal of medicinal chemistry, 06 October 2005, Vol.48(20), pp.6169-73 [Peer Reviewed Journal]

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61
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Antagonists of human CCR5 receptor containing 4-(pyrazolyl)piperidine side chains. Part 1: Discovery and SAR study of 4-pyrazolylpiperidine side chains

Shen, Dong-Ming ; Shu, Min ; Mills, Sander G. ; Chapman, Kevin T. ; Malkowitz, Lorraine ; Springer, Martin S. ; Gould, Sandra L. ; Demartino, Julie A. ; Siciliano, Salvatore J. ; Kwei, Gloria Y. ; Carella, Anthony ; Carver, Gwen ; Holmes, Karen ; Schleif, William A. ; Danzeisen, Renee ; Hazuda, Daria ; Kessler, Joseph ; Lineberger, Janet ; Miller, Michael D. ; Emini, Emilio A.

Bioorganic & Medicinal Chemistry Letters, 23 February 2004, Vol.14(4), pp.935-939 [Peer Reviewed Journal]

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62
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Antagonists of human CCR5 receptor containing 4-(pyrazolyl)piperidine side chains. Part 3: SAR studies on the benzylpyrazole segment

Shu, Min ; Loebach, Jennifer L ; Parker, Kerry A ; Mills, Sander G ; Chapman, Kevin T ; Shen, Dong-Ming ; Malkowitz, Lorraine ; Springer, Martin S ; Gould, Sandra L ; Demartino, Julie A ; Siciliano, Salvatore J ; Salvo, Jerry Di ; Lyons, Kathy ; Pivnichny, James V ; Kwei, Gloria Y ; Carella, Anthony ; Carver, Gwen ; Holmes, Karen ; Schleif, William A ; Danzeisen, Renee ; Hazuda, Daria ; Kessler, Joseph ; Lineberger, Janet ; Miller, Michael D ; Emini, Emilio A

Bioorganic & Medicinal Chemistry Letters, 23 February 2004, Vol.14(4), pp.947-952 [Peer Reviewed Journal]

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63
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Syntheses and biological evaluation of 5-(piperidin-1-yl)-3-phenyl-pentylsulfones as CCR5 antagonists

Shankaran, K. ; Donnelly, Karla L. ; Shah, Shrenik K. ; Caldwell, Charles G. ; Chen, Ping ; Finke, Paul E. ; Oates, Bryan ; Maccoss, Malcolm ; Mills, Sander G. ; Demartino, Julie A. ; Gould, Sandra L. ; Malkowitz, Lorraine ; Siciliano, Salvatore J. ; Springer, Martin S. ; Kwei, Gloria ; Carella, Anthony ; Carver, Gwen ; Danzeisen, Renee ; Hazuda, Daria ; Holmes, Karen ; Kessler, Joseph ; Lineberger, Janet ; Miller, Michael D. ; Emini, Emilio A. ; Schleif, William A.

Bioorganic & Medicinal Chemistry Letters, 2004, Vol.14(13), pp.3589-3593 [Peer Reviewed Journal]

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64
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Antagonists of human CCR5 receptor containing 4-(pyrazolyl)piperidine side chains. Part 2: Discovery of potent, selective, and orally bioavailable compounds

Shen, Dong-Ming ; Shu, Min ; Willoughby, Christopher A. ; Shah, Shrenik ; Lynch, Christopher L. ; Hale, Jeffrey J. ; Mills, Sander G. ; Chapman, Kevin T. ; Malkowitz, Lorraine ; Springer, Martin S. ; Gould, Sandra L. ; Demartino, Julie A. ; Siciliano, Salvatore J. ; Lyons, Kathy ; Pivnichny, James V. ; Kwei, Gloria Y. ; Carella, Anthony ; Carver, Gwen ; Holmes, Karen ; Schleif, William A. ; Danzeisen, Renee ; Hazuda, Daria ; Kessler, Joseph ; Lineberger, Janet ; Miller, Michael D. ; Emini, Emilio A.

Bioorganic & Medicinal Chemistry Letters, 23 February 2004, Vol.14(4), pp.941-945 [Peer Reviewed Journal]

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65
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CCR5 antagonists: bicyclic isoxazolidines as conformationally constrained N-1-substituted pyrrolidines

Lynch, Christopher L ; Gentry, Amy L ; Hale, Jeffrey J ; Mills, Sander G ; Maccoss, Malcolm ; Malkowitz, Lorraine ; Springer, Martin S ; Gould, Sandra L ; Demartino, Julie A ; Siciliano, Salvatore J ; Cascieri, Margaret A ; Doss, George ; Carella, Anthony ; Carver, Gwen ; Holmes, Karen ; Schleif, William A ; Danzeisen, Renee ; Hazuda, Daria ; Kessler, Joseph ; Lineberger, Janet ; Miller, Michael ; Emini, Emilio A

Bioorganic & Medicinal Chemistry Letters, 2002, Vol.12(4), pp.677-679 [Peer Reviewed Journal]

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66
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1,3,4-Trisubstituted pyrrolidine CCR5 receptor antagonists. Part 4: Synthesis of N-1 acidic functionality affording analogues with enhanced antiviral activity against HIV

Lynch, Christopher L ; Hale, Jeffrey J ; Budhu, Richard J ; Gentry, Amy L ; Mills, Sander G ; Chapman, Kevin T ; Maccoss, Malcolm ; Malkowitz, Lorraine ; Springer, Martin S ; Gould, Sandra L ; Demartino, Julie A ; Siciliano, Salvatore J ; Cascieri, Margaret A ; Carella, Anthony ; Carver, Gwen ; Holmes, Karen ; Schleif, William A ; Danzeisen, Renee ; Hazuda, Daria ; Kessler, Joseph ; Lineberger, Janet ; Miller, Michael ; Emini, Emilio A

Bioorganic & Medicinal Chemistry Letters, 21 October 2002, Vol.12(20), pp.3001-3004 [Peer Reviewed Journal]

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67
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Substituted N-(3,5-Dichlorobenzenesulfonyl)- l-prolyl-phenylalanine analogues as potent VLA-4 antagonists

Kopka, Ihor E ; Young, David N ; Lin, Linus S ; Mumford, Richard A ; Magriotis, Plato A ; Maccoss, Malcolm ; Mills, Sander G ; Riper, Gail Van ; Mccauley, Ermengilda ; Egger, Linda E ; Kidambi, Usha ; Schmidt, John A ; Lyons, Kathryn ; Stearns, Ralph ; Vincent, Stella ; Colletti, Adria ; Wang, Zhen ; Tong, Sharon ; Wang, Junying ; Zheng, Song ; Owens, Karen ; Levorse, Dorothy ; Hagmann, William K

Bioorganic & Medicinal Chemistry Letters, 2002, Vol.12(4), pp.637-640 [Peer Reviewed Journal]

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68
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1,3,4 trisubstituted pyrrolidine CCR5 receptor antagonists bearing 4-aminoheterocycle substituted piperidine side chains

Willoughby, Christopher A ; Rosauer, Keith G ; Hale, Jeffery J ; Budhu, Richard J ; Mills, Sander G ; Chapman, Kevin T ; Maccoss, Malcolm ; Malkowitz, Lorraine ; Springer, Martin S ; Gould, Sandra L ; Demartino, Julie A ; Siciliano, Salvatore J ; Cascieri, Margaret A ; Carella, Anthony ; Carver, Gwen ; Holmes, Karen ; Schleif, William A ; Danzeisen, Renee ; Hazuda, Daria ; Kessler, Joseph ; Lineberger, Janet ; Miller, Michael ; Emini, Emilio A

Bioorganic & Medicinal Chemistry Letters, 2003, Vol.13(3), pp.427-431 [Peer Reviewed Journal]

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69
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Discovery of human CCR5 antagonists containing hydantoins for the treatment of HIV-1 infection

Kim, Dooseop ; Wang, Liping ; Caldwell, Charles G. ; Chen, Ping ; Finke, Paul E. ; Oates, Bryan ; Maccoss, Malcolm ; Mills, Sander G. ; Malkowitz, Lorraine ; Gould, Sandra L. ; Demartino, Julie A. ; Springer, Martin S. ; Hazuda, Daria ; Miller, Michael ; Kessler, Joseph ; Danzeisen, Renee ; Carver, Gwen ; Carella, Anthony ; Holmes, Karen ; Lineberger, Janet ; Schleif, William A. ; Emini, Emilio A.

Bioorganic & Medicinal Chemistry Letters, 2001, Vol.11(24), pp.3099-3102 [Peer Reviewed Journal]

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70
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Antagonists of the human CCR5 receptor as anti-HIV-1 agents. Part 2: structure–activity relationships for substituted 2-aryl-1-[N-(methyl)-N-(phenylsulfonyl)amino]-4-(piperidin-1-yl)butanes

Finke, Paul E ; Meurer, Laura C ; Oates, Bryan ; Mills, Sander G ; Maccoss, Malcolm ; Malkowitz, Lorraine ; Springer, Martin S ; Daugherty, Bruce L ; Gould, Sandra L ; Demartino, Julie A ; Siciliano, Salvatore J ; Carella, Anthony ; Carver, Gwen ; Holmes, Karen ; Danzeisen, Renee ; Hazuda, Daria ; Kessler, Joseph ; Lineberger, Janet ; Miller, Michael ; Schleif, William A ; Emini, Emilio A

Bioorganic & Medicinal Chemistry Letters, January 2001, Vol.11(2), pp.265-270 [Peer Reviewed Journal]

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71
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Substituted 3-amino biaryl propionic acids as potent VLA-4 antagonists

Kopka, Ihor E ; Lin, Linus S ; Mumford, Richard A ; Lanza, Thomas ; Magriotis, Plato A ; Young, David ; Delaszlo, Stephen E ; Maccoss, Malcolm ; Mills, Sander G ; Van Riper, Gail ; Mccauley, Ermengilda ; Lyons, Kathryn ; Vincent, Stella ; Egger, Linda A ; Kidambi, Usha ; Stearns, Ralph ; Colletti, Adria ; Teffera, Yohannes ; Tong, Sharon ; Owens, Karen ; Levorse, Dorothy ; Schmidt, John A ; Hagmann, William K

Bioorganic & Medicinal Chemistry Letters, 2002, Vol.12(17), pp.2415-2418 [Peer Reviewed Journal]

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72
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1,3,4-Trisubstituted pyrrolidine CCR5 receptor antagonists. Part 2: lead optimization affording selective, orally bioavailable compounds with potent Anti-HIV activity

Hale, Jeffrey J. ; Budhu, Richard J. ; Holson, Edward B. ; Finke, Paul E. ; Oates, Bryan ; Mills, Sander G. ; Maccoss, Malcolm ; Gould, Sandra L. ; Demartino, Julie A. ; Springer, Martin S. ; Siciliano, Salvatore ; Malkowitz, Lorraine ; Schleif, William A. ; Hazuda, Daria ; Miller, Michael ; Kessler, Joseph ; Danzeisen, Renee ; Holmes, Karen ; Lineberger, Janet ; Carella, Anthony ; Carver, Gwen ; Emini, Emilio

Bioorganic & Medicinal Chemistry Letters, 2001, Vol.11(20), pp.2741-2745 [Peer Reviewed Journal]

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73
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1,4-Diacylpiperazine-2-(S)-[(N-aminoalkyl)carboxamides] as novel, potent substance P receptor antagonists.

Mills, Sander G. ; Wu, Mu Tsu ; Maccoss, Malcolm ; Budhu, Richard J. ; Dorn, Conrad P. ; Cascieri, Margaret A. ; Sadowski, Sharon ; Strader, Catherine D. ; Greenlee, William J.

Bioorganic & Medicinal Chemistry Letters, 1993, Vol.3(12), pp.2707-2712 [Peer Reviewed Journal]

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74
Structural Optimization Affording 2-( R )-(1-( R )-3,5-Bis(trifluoromethyl)phenylethoxy)-3-( S )-(4-fluoro)phenyl-4- (3-oxo-1,2,4-triazol-5-yl)methylmorpholine, a Potent, Orally Active, Long-Acting Morpholine Acetal Human NK-1 Receptor Antagonist
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Structural Optimization Affording 2-( R )-(1-( R )-3,5-Bis(trifluoromethyl)phenylethoxy)-3-( S )-(4-fluoro)phenyl-4- (3-oxo-1,2,4-triazol-5-yl)methylmorpholine, a Potent, Orally Active, Long-Acting Morpholine Acetal Human NK-1 Receptor Antagonist

Hale, Jeffrey J. ; Mills, Sander G. ; Maccoss, Malcolm ; Finke, Paul E. ; Cascieri, Margaret A. ; Sadowski, Sharon ; Ber, Elzbieta ; Chicchi, Gary G. ; Kurtz, Marc ; Metzger, Joseph ; Eiermann, George ; Tsou, Nancy N. ; Tattersall, F. David ; Rupniak, Nadia M. J. ; Williams, Angela R. ; Rycroft, Wayne ; Hargreaves, Richard ; Macintyre, D. Euan

Journal of Medicinal Chemistry, 11/1998, Vol.41(23), pp.4607-4614 [Peer Reviewed Journal]

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75
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Alpha-aminothiazole-gamma-aminobutanoic amides as potent, small molecule CCR2 receptor antagonists

Zhou, Changyou ; Guo, Liangqin ; Parsons, William H ; Mills, Sander G ; Maccoss, Malcolm ; Vicario, Pasquale P ; Zweerink, Hans ; Cascieri, Margaret A ; Springer, Martin S ; Yang, Lihu

Bioorganic & medicinal chemistry letters, 15 January 2007, Vol.17(2), pp.309-14 [Peer Reviewed Journal]

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76
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α-Aminothiazole-γ-aminobutanoic amides as potent, small molecule CCR2 receptor antagonists

Zhou, Changyou ; Guo, Liangqin ; Parsons, William H. ; Mills, Sander G. ; Maccoss, Malcolm ; Vicario, Pasquale P. ; Zweerink, Hans ; Cascieri, Margaret A. ; Springer, Martin S. ; Yang, Lihu

Bioorganic & Medicinal Chemistry Letters, 2007, Vol.17(2), pp.309-314 [Peer Reviewed Journal]

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77
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The discovery of sulfonylated dipeptides as Potent VLA-4 antagonists

Hagmann, William K ; Durette, Philippe L ; Lanza, Thomas ; Kevin, Nancy Jo ; de Laszlo, Stephen E ; Kopka, Ihor E ; Young, David ; Magriotis, Plato A ; Li, Bing ; Lin, Linus S ; Yang, Ginger ; Kamenecka, Theodore ; Chang, Linda L ; Wilson, Jonathan ; Maccoss, Malcolm ; Mills, Sander G ; Van Riper, Gail ; Mccauley, Ermengilda ; Egger, Linda A ; Kidambi, Usha ; Lyons, Kathryn ; Vincent, Stella ; Stearns, Ralph ; Colletti, Adria ; Teffera, Johannes ; Tong, Sharon ; Fenyk-Melody, Judy ; Owens, Karen ; Levorse, Dorothy ; Kim, Philip ; Schmidt, John A ; Mumford, Richard A

Bioorganic & Medicinal Chemistry Letters, 2001, Vol.11(20), pp.2709-2713 [Peer Reviewed Journal]

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78
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1,3,4-Trisubstituted pyrrolidine CCR5 receptor antagonists: modifications of the arylpropylpiperidine side chains

Lynch, Christopher L. ; Willoughby, Christopher A. ; Hale, Jeffrey J. ; Holson, Edward J. ; Budhu, Richard J. ; Gentry, Amy L. ; Rosauer, Keith G. ; Caldwell, Charles G. ; Chen, Ping ; Mills, Sander G. ; Maccoss, Malcolm ; Berk, Scott ; Chen, Liya ; Chapman, Kevin T. ; Malkowitz, Lorraine ; Springer, Martin S. ; Gould, Sandra L. ; Demartino, Julie A. ; Siciliano, Salvatore J. ; Cascieri, Margaret A. ; Carella, Anthony ; Carver, Gwen ; Holmes, Karen ; Schleif, William A. ; Danzeisen, Renee ; Hazuda, Daria ; Kessler, Joseph ; Lineberger, Janet ; Miller, Michael ; Emini, Emilio A.

Bioorganic & Medicinal Chemistry Letters, 2003, Vol.13(1), pp.119-123 [Peer Reviewed Journal]

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79
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Expression and characterization of the chemokine receptor CCR2B from rhesus monkey

Jin, Hong ; Vicario, Pasquale P. ; Zweerink, Hans ; Goyal, Shefali ; Hanlon, William A. ; Dorn, Conrad P. ; Mills, Sander G. ; Demartino, Julie A. ; Cascieri, Margaret A. ; Struthers, Mary

Biochemical Pharmacology, 2003, Vol.66(2), pp.321-330 [Peer Reviewed Journal]

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80
Phosphorylated Morpholine Acetal Human Neurokinin-1 Receptor Antagonists as Water-Soluble Prodrugs
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Phosphorylated Morpholine Acetal Human Neurokinin-1 Receptor Antagonists as Water-Soluble Prodrugs

Hale, Jeffrey J. ; Mills, Sander G. ; Maccoss, Malcolm ; Dorn, Conrad P. ; Finke, Paul E. ; Budhu, Richard J. ; Reamer, Robert A. ; Huskey, Su-Er W. ; Luffer-Atlas, Debra ; Dean, Brian J. ; Mcgowan, Erin M. ; Feeney, William P. ; Chiu, Shuet-Hing Lee ; Cascieri, Margaret A. ; Chicchi, Gary G. ; Kurtz, Marc M. ; Sadowski, Sharon ; Ber, Elzbieta ; Tattersall, F. David ; Rupniak, Nadia M. J. ; Williams, Angela R. ; Rycroft, Wayne ; Hargreaves, Richard ; Metzger, Joseph M. ; Macintyre, D. Euan

Journal of Medicinal Chemistry, 03/2000, Vol.43(6), pp.1234-1241 [Peer Reviewed Journal]

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81
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Identification of Leu276 of the S1P1 receptor and Phe263 of the S1P3 receptor in interaction with receptor specific agonists by molecular modeling, site-directed mutagenesis, and affinity studies

Deng, Qiaolin ; Clemas, Joseph A ; Chrebet, Gary ; Fischer, Paul ; Hale, Jeffrey J ; Li, Zhen ; Mills, Sander G ; Bergstrom, James ; Mandala, Suzanne ; Mosley, Ralph ; Parent, Stephen A

Molecular pharmacology, March 2007, Vol.71(3), pp.724-35 [Peer Reviewed Journal]

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82
Antagonists of the human CCR5 receptor as anti-HIV-1 agents. Part 4: synthesis and structure–Activity relationships for 1-[N-(Methyl)-N-(phenylsulfonyl)amino]-2-(phenyl)-4-(4-(N-(alkyl)-N-(benzyloxycarbonyl)amino)piperidin-1-yl)butanes
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Antagonists of the human CCR5 receptor as anti-HIV-1 agents. Part 4: synthesis and structure–Activity relationships for 1-[N-(Methyl)-N-(phenylsulfonyl)amino]-2-(phenyl)-4-(4-(N-(alkyl)-N-(benzyloxycarbonyl)amino)piperidin-1-yl)butanes

Finke, Paul E. ; Oates, Bryan ; Mills, Sander G. ; Maccoss, Malcolm ; Malkowitz, Lorraine ; Springer, Martin S. ; Gould, Sandra L. ; Demartino, Julie A. ; Carella, Anthony ; Carver, Gwen ; Holmes, Karen ; Danzeisen, Renee ; Hazuda, Daria ; Kessler, Joseph ; Lineberger, Janet ; Miller, Michael ; Schleif, William A. ; Emini, Emilio A.

Bioorganic & Medicinal Chemistry Letters, 9/2001, Vol.11(18), pp.2475-2479 [Peer Reviewed Journal]

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83
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Design and synthesis of conformationally constrained 3-(N-alkylamino)propylphosphonic acids as potent agonists of sphingosine-1-phosphate (S1P) receptors

Yan, Lin ; Hale, Jeffrey J ; Lynch, Christopher L ; Budhu, Richard ; Gentry, Amy ; Mills, Sander G ; Hajdu, Richard ; Keohane, Carol Ann ; Rosenbach, Mark J ; Milligan, James A ; Shei, Gan-Ju ; Chrebet, Gary ; Bergstrom, James ; Card, Deborah ; Rosen, Hugh ; Mandala, Suzanne M

Bioorganic & medicinal chemistry letters, 04 October 2004, Vol.14(19), pp.4861-6 [Peer Reviewed Journal]

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84
Design and synthesis of conformationally constrained 3-(N-alkylamino)propylphosphonic acids as potent agonists of sphingosine-1-phosphate (S1P) receptors
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Design and synthesis of conformationally constrained 3-(N-alkylamino)propylphosphonic acids as potent agonists of sphingosine-1-phosphate (S1P) receptors

Yan, Lin ; Hale, Jeffrey J. ; Lynch, Christopher L. ; Budhu, Richard ; Gentry, Amy ; Mills, Sander G. ; Hajdu, Richard ; Keohane, Carol Ann ; Rosenbach, Mark J. ; Milligan, James A. ; Shei, Gan-Ju ; Chrebet, Gary ; Bergstrom, James ; Card, Deborah ; Rosen, Hugh ; Mandala, Suzanne M.

Bioorganic & Medicinal Chemistry Letters, 10/2004, Vol.14(19), pp.4861-4866 [Peer Reviewed Journal]

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85
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Comparison of the functional blockade of rat substance P (NK 1) receptors by GR205171, RP67580, SR140333 and NKP-608

Rupniak, Nadia M.J ; Carlson, Emma J ; Shepheard, Sara ; Bentley, Graham ; Williams, Angela R ; Hill, Alastair ; Swain, Christopher ; Mills, Sander G ; Di Salvo, Jerry ; Kilburn, Ruth ; Cascieri, Margaret A ; Kurtz, Marc M ; Tsao, Kwei-Lan ; Gould, Sandra L ; Chicchi, Gary G

Neuropharmacology, 2003, Vol.45(2), pp.231-241 [Peer Reviewed Journal]

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