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Results 51 - 100 of 158  for Everything (Includes Articles)

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51
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Highly constrained bicyclic VLA-4 antagonists

Chang, Linda L ; Truong, Quang ; Doss, George A ; Maccoss, Malcolm ; Lyons, Kathryn ; Mccauley, Ermengilda ; Mumford, Richard ; Forrest, Gail ; Vincent, Stella ; Schmidt, John A ; Hagmann, William K

Bioorganic & Medicinal Chemistry Letters, 2007, Vol.17(3), pp.597-601 [Peer Reviewed Journal]

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52
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α-Aminothiazole-γ-aminobutanoic amides as potent, small molecule CCR2 receptor antagonists

Zhou, Changyou ; Guo, Liangqin ; Parsons, William H ; Mills, Sander G ; Maccoss, Malcolm ; Vicario, Pasquale P ; Zweerink, Hans ; Cascieri, Margaret A ; Springer, Martin S ; Yang, Lihu

Bioorganic & Medicinal Chemistry Letters, 2007, Vol.17(2), pp.309-314 [Peer Reviewed Journal]

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53
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4-Amino-2-alkyl-butyramides as small molecule CCR2 antagonists with favorable pharmacokinetic properties

Butora, Gabor ; Morriello, Gregori J ; Kothandaraman, Shankaran ; Guiadeen, Deodialsingh ; Pasternak, Alexander ; Parsons, William H ; Maccoss, Malcolm ; Vicario, Pasquale P ; Cascieri, Margaret A ; Yang, Lihu

Bioorganic & Medicinal Chemistry Letters, 15 September 2006, Vol.16(18), pp.4715-4722 [Peer Reviewed Journal]

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54
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Synthesis and evaluation of optically pure dioxolanes as inhibitors of hepatitis C virus RNA replication

Bera, Sanjib ; Malik, Leila ; Bhat, Balkrishen ; Carroll, Steven S ; Maccoss, Malcolm ; Olsen, David B ; Tomassini, Joanne E ; Eldrup, Anne B

Bioorganic & Medicinal Chemistry Letters, 15 December 2003, Vol.13(24), pp.4455-4458 [Peer Reviewed Journal]

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55
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1,3,4-Trisubstituted pyrrolidine CCR5 receptor antagonists. Part 1: discovery of the pyrrolidine scaffold and determination of its stereochemical requirements

Hale, Jeffrey J ; Budhu, Richard J ; Mills, Sander G ; Maccoss, Malcolm ; Malkowitz, Lorraine ; Siciliano, Salvatore ; Gould, Sandra L ; Demartino, Julie A ; Springer, Martin S

Bioorganic & Medicinal Chemistry Letters, 2001, Vol.11(11), pp.1437-1440 [Peer Reviewed Journal]

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56
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Design, synthesis, and structure–activity relationship of novel CCR2 antagonists

Kothandaraman, Shankaran ; Donnely, Karla L ; Butora, Gabor ; Jiao, Richard ; Pasternak, Alexander ; Morriello, Gregori J ; Goble, Stephen D ; Zhou, Changyou ; Mills, Sander G ; Maccoss, Malcolm ; Vicario, Pasquale P ; Ayala, Julia M ; Demartino, Julie A ; Struthers, Mary ; Cascieri, Margaret A ; Yang, Lihu

Bioorganic & Medicinal Chemistry Letters, 2009, Vol.19(6), pp.1830-1834 [Peer Reviewed Journal]

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57
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Synthesis and biological evaluation of platensimycin analogs

Shen, Hong C ; Ding, Fa-Xiang ; Singh, Sheo B ; Parthasarathy, Gopalakrishnan ; Soisson, Stephen M ; Ha, Sookhee N ; Chen, Xun ; Kodali, Srinivas ; Wang, Jun ; Dorso, Karen ; Tata, James R ; Hammond, Milton L ; Maccoss, Malcolm ; Colletti, Steven L

Bioorganic & Medicinal Chemistry Letters, 2009, Vol.19(6), pp.1623-1627 [Peer Reviewed Journal]

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58
Inhibition of Stromelysin-1 (MMP-3) by P 1 ‘-Biphenylylethyl Carboxyalkyl Dipeptides
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Inhibition of Stromelysin-1 (MMP-3) by P 1 ‘-Biphenylylethyl Carboxyalkyl Dipeptides

Esser, Craig K. ; Bugianesi, Robert L. ; Caldwell, Charles G. ; Chapman, Kevin T. ; Durette, Philippe L. ; Girotra, Narindar N. ; Kopka, Ihor E. ; Lanza, Thomas J. ; Levorse, Dorothy A. ; Maccoss, Malcolm ; Owens, Karen A. ; Ponpipom, Mitree M. ; Simeone, Joseph P. ; Harrison, Richard K. ; Niedzwiecki, Lisa ; Becker, Joseph W. ; Marcy, Alice I. ; Axel, Melinda G. ; Christen, Amy J. ; Mcdonnell, Joseph ; Moore, Vernon L. ; Olszewski, Julie M. ; Saphos, Cheryl ; Visco, Denise M. ; Shen, Frank ; Colletti, Adria ; Krieter, Philip A. ; Hagmann, William K.

Journal of Medicinal Chemistry, 03/1997, Vol.40(6), pp.1026-1040 [Peer Reviewed Journal]

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59
Phosphorylated Morpholine Acetal Human Neurokinin-1 Receptor Antagonists as Water-Soluble Prodrugs
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Phosphorylated Morpholine Acetal Human Neurokinin-1 Receptor Antagonists as Water-Soluble Prodrugs

Hale, Jeffrey J. ; Mills, Sander G. ; Maccoss, Malcolm ; Dorn, Conrad P. ; Finke, Paul E. ; Budhu, Richard J. ; Reamer, Robert A. ; Huskey, Su-Er W. ; Luffer-Atlas, Debra ; Dean, Brian J. ; Mcgowan, Erin M. ; Feeney, William P. ; Chiu, Shuet-Hing Lee ; Cascieri, Margaret A. ; Chicchi, Gary G. ; Kurtz, Marc M. ; Sadowski, Sharon ; Ber, Elzbieta ; Tattersall, F. David ; Rupniak, Nadia M. J. ; Williams, Angela R. ; Rycroft, Wayne ; Hargreaves, Richard ; Metzger, Joseph M. ; Macintyre, D. Euan

Journal of Medicinal Chemistry, 03/2000, Vol.43(6), pp.1234-1241 [Peer Reviewed Journal]

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60
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Phenylalkyl ketones as potent reversible inhibitors of interleukin-1β converting enzyme

Mjalli, Adnan M.M ; Chapman, Kevin T ; Maccoss, Malcolm ; Thornberry, Nancy A

Bioorganic & Medicinal Chemistry Letters, 1993, Vol.3(12), pp.2689-2692 [Peer Reviewed Journal]

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61
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Inhibition of interleukin-1β converting enzyme by N-acyl-aspartyl aryloxymethyl ketones

Mjalli, Adnan M.M ; Zhao, Justin J ; Chapman, Kevin T ; Thornberry, Nancy A ; Peterson, Erin P ; Maccoss, Malcolm ; Hagmann, William K

Bioorganic & Medicinal Chemistry Letters, 1995, Vol.5(13), pp.1409-1414 [Peer Reviewed Journal]

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62
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1,2,4-Triacylpiperidine substance p antagonists: Separation of affinities for the NK-1 receptor and the L-type calcium channel

Mills, Sander G ; Maccoss, Malcolm ; Cascieri, Margaret A ; Sadowski, Sharon ; Patel, Smita ; Chapman, Kerry L ; Hutson, Peter H

Bioorganic & Medicinal Chemistry Letters, 1995, Vol.5(6), pp.599-604 [Peer Reviewed Journal]

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63
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Cyclopentane-based human NK1 antagonists. Part 1: Discovery and initial SAR

Finke, Paul E ; Meurer, Laura C ; Levorse, Dorothy A ; Mills, Sander G ; Maccoss, Malcolm ; Sadowski, Sharon ; Cascieri, Margaret A ; Tsao, Kwei-Lan ; Chicchi, Gary G ; Metzger, Joseph M ; Macintyre, D. Euan

Bioorganic & Medicinal Chemistry Letters, 2006, Vol.16(17), pp.4497-4503 [Peer Reviewed Journal]

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64
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Bioisosteric replacement of anilide with benzoxazole: potent and orally bioavailable antagonists of VLA-4

Lin, Linus S ; Lanza, Thomas J ; Castonguay, Laurie A ; Kamenecka, Theodore ; Mccauley, Ermenegilda ; Van Riper, Gail ; Egger, Linda A ; Mumford, Richard A ; Tong, Xinchun ; Maccoss, Malcolm ; Schmidt, John A ; Hagmann, William K

Bioorganic & Medicinal Chemistry Letters, 03 May 2004, Vol.14(9), pp.2331-2334 [Peer Reviewed Journal]

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65
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Evaluation of pyrrolidin-2-imines and 1,3-thiazolidin-2-imines as inhibitors of nitric oxide synthase

Shankaran, K ; Donnelly, Karla L ; Shah, Shrenik K ; Guthikonda, Ravindra N ; Maccoss, Malcolm ; Humes, John L ; Pacholok, Stephen G ; Grant, Stephan K ; Kelly, T.M ; Wong, K.K

Bioorganic & Medicinal Chemistry Letters, 2004, Vol.14(17), pp.4539-4544 [Peer Reviewed Journal]

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66
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Synthesis of analogs of (1,4)-3- and 5-imino oxazepane, thiazepane, and diazepane as inhibitors of nitric oxide synthases

Shankaran, K ; Donnelly, Karla L ; Shah, Shrenik K ; Caldwell, Charles G ; Chen, Ping ; Hagmann, William K ; Maccoss, Malcolm ; Humes, John L ; Pacholok, Stephen G ; Kelly, Theresa M ; Grant, Stephan K ; Wong, Kenny K

Bioorganic & Medicinal Chemistry Letters, 2004, Vol.14(23), pp.5907-5911 [Peer Reviewed Journal]

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67
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The discovery of small molecule carbamates as potent dual α 4β 1/α 4β 7 integrin antagonists

Chang, Linda L ; Truong, Quang ; Mumford, Richard A ; Egger, Linda A ; Kidambi, Usha ; Lyons, Kathryn ; Mccauley, Ermengilda ; Van Riper, Gail ; Vincent, Stella ; Schmidt, John A ; Maccoss, Malcolm ; Hagmann, William K

Bioorganic & Medicinal Chemistry Letters, 2002, Vol.12(2), pp.159-163 [Peer Reviewed Journal]

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68
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Substituted Imidazoles as Glucagon Receptor Antagonists

Chang, Linda L ; Sidler, Kelly L ; Cascieri, Margaret A ; de Laszlo, Stephen ; Koch, Greg ; Li, Bing ; Maccoss, Malcolm ; Mantlo, Nathan ; O'Keefe, Stephen ; Pang, Margaret ; Rolando, Anna ; Hagmann, William K

Bioorganic & Medicinal Chemistry Letters, 2001, Vol.11(18), pp.2549-2553 [Peer Reviewed Journal]

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69
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Antagonists of the human CCR5 receptor as anti-HIV-1 agents. Part 4: synthesis and structure–Activity relationships for 1-[ N-(Methyl)- N-(phenylsulfonyl)amino]-2-(phenyl)-4-(4-( N-(alkyl)- N-(benzyloxycarbonyl)amino)piperidin-1-yl)butanes

Finke, Paul E ; Oates, Bryan ; Mills, Sander G ; Maccoss, Malcolm ; Malkowitz, Lorraine ; Springer, Martin S ; Gould, Sandra L ; Demartino, Julie A ; Carella, Anthony ; Carver, Gwen ; Holmes, Karen ; Danzeisen, Renee ; Hazuda, Daria ; Kessler, Joseph ; Lineberger, Janet ; Miller, Michael ; Schleif, William A ; Emini, Emilio A

Bioorganic & Medicinal Chemistry Letters, 2001, Vol.11(18), pp.2475-2479 [Peer Reviewed Journal]

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70
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Specific and dual antagonists of α 4β 1 and α 4β 7 integrins

Lin, Linus S ; Lanza, Thomas ; Mccauley, Ermenegilda ; Riper, Gail Van ; Kidambi, Usha ; Cao, Jin ; Egger, Linda A ; Mumford, Richard A ; Schmidt, John A ; Maccoss, Malcolm ; Hagmann, William K

Bioorganic & Medicinal Chemistry Letters, 2002, Vol.12(2), pp.133-136 [Peer Reviewed Journal]

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71
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Phospholipid-nucleoside conjugates. 5. The interaction of selected [formula omitted] with serum lipoproteins

Maccoss, Malcolm ; Edwards, Jesse J ; Lagocki, Peter ; Rahman, Yueh-Erh

Biochemical and Biophysical Research Communications, 1983, Vol.116(2), pp.368-374 [Peer Reviewed Journal]

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72
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Activated ketones as potent reversible inhibitors of interleukin-Iβ converting enzyme

Mjalli, Adnan M.M ; Chapman, Kevin T ; Maccoss, Malcolm ; Thornberry, Nancy A ; Peterson, Erin P

Bioorganic & Medicinal Chemistry Letters, 1994, Vol.4(16), pp.1965-1968 [Peer Reviewed Journal]

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73
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NK2 receptors mediate plasma extravasation in guinea‐pig lower airways

Tousignant, Christine ; Chan, Chi‐Chung ; Guevremont, Diane ; Brideau, Christine ; Hale, Jeffrey J. ; Maccoss, Malcolm ; Rodger, Ian W.

British Journal of Pharmacology, February 1993, Vol.108(2), pp.383-386 [Peer Reviewed Journal]

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74
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Inhibition of nitric oxide synthase by benzoxazolones

Shankaran, K ; Donnelly, Karla L ; Shah, Shrenik K ; Humes, John L ; Pacholok, Stephen G ; Grant, Stephan K ; Green, Barbara G ; Maccoss, Malcolm

Bioorganic & Medicinal Chemistry Letters, 1997, Vol.7(22), pp.2887-2892 [Peer Reviewed Journal]

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75
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1,2,3-Trisubstituted cyclohexyl substance P antagonists: significance of the ring nitrogen in piperidine-based NK-1 receptor antagonists

Mills, Sander G ; Maccoss, Malcolm ; Underwood, Dennis ; Shah, Shrenik K ; Finke, Paul E ; Miller, Daniel J ; Budhu, Richard J ; Cascieri, Margaret A ; Sadowski, Sharon ; Strader, Catherine D

Bioorganic & Medicinal Chemistry Letters, 1995, Vol.5(13), pp.1345-1350 [Peer Reviewed Journal]

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76
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Potent, orally absorbed glucagon receptor antagonists

de Laszlo, Stephen E ; Hacker, Candice ; Li, Bing ; Kim, Dooseop ; Maccoss, Malcolm ; Mantlo, Nathan ; Pivnichny, James V ; Colwell, Larry ; Koch, Gregory E ; Cascieri, Margaret A ; Hagmann, William K

Bioorganic & Medicinal Chemistry Letters, 1999, Vol.9(5), pp.641-646 [Peer Reviewed Journal]

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77
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Discovery of 3,5-bis(trifluoromethyl)benzyl l-arylglycinamide based potent CCR2 antagonists

Yang, Lihu ; Zhou, Changyou ; Guo, Liangqin ; Morriello, Gregori ; Butora, Gabor ; Pasternak, Alexander ; Parsons, William H ; Mills, Sander G ; Maccoss, Malcolm ; Vicario, Pasquale P ; Zweerink, Hans ; Ayala, Julia M ; Goyal, Shefali ; Hanlon, William A ; Cascieri, Margaret A ; Springer, Marty S

Bioorganic & Medicinal Chemistry Letters, 2006, Vol.16(14), pp.3735-3739 [Peer Reviewed Journal]

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78
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The discovery of a potent and selective lethal factor inhibitor for adjunct therapy of anthrax infection

Xiong, Yusheng ; Wiltsie, Judyann ; Woods, Andrea ; Guo, Jian ; Pivnichny, James V ; Tang, Wei ; Bansal, Alka ; Cummings, Richard T ; Cunningham, Barry R ; Friedlander, Arthur M ; Douglas, Cameron M ; Salowe, Scott P ; Zaller, Dennis M ; Scolnick, Edward M ; Schmatz, Dennis M ; Bartizal, Kenneth ; Hermes, Jeffrey D ; Maccoss, Malcolm ; Chapman, Kevin T

Bioorganic & Medicinal Chemistry Letters, 2006, Vol.16(4), pp.964-968 [Peer Reviewed Journal]

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79
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Synthesis and evaluation of CCR5 antagonists containing modified 4-piperidinyl-2-phenyl-1-(phenylsulfonylamino)-butane

Shah, Shrenik K ; Chen, Natalie ; Guthikonda, Ravindra N ; Mills, Sander G ; Malkowitz, Lorraine ; Springer, Martin S ; Gould, Sandra L ; Demartino, Julie A ; Carella, Anthony ; Carver, Gwen ; Holmes, Karen ; Schleif, William A ; Danzeisen, Renee ; Hazuda, Daria ; Kessler, Joseph ; Lineberger, Janet ; Miller, Michael ; Emini, Emilio A ; Maccoss, Malcolm

Bioorganic & Medicinal Chemistry Letters, 2005, Vol.15(4), pp.977-982 [Peer Reviewed Journal]

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80
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Bicyclic amidine inhibitors of nitric oxide synthase: discovery of perhydro-iminopyrindine and perhydro-iminoquinoline as potent, orally active inhibitors of inducible nitric oxide synthase

Guthikonda, Ravindra N ; Shah, Shrenik K ; Pacholok, Stephen G ; Humes, John L ; Mumford, Richard A ; Grant, Stephan K ; Chabin, Renee M ; Green, Barbara G ; Tsou, Nancy ; Ball, Richard ; Fletcher, Daniel S ; Luell, Silvi ; Euan Macintyre, D ; Maccoss, Malcolm

Bioorganic & Medicinal Chemistry Letters, 2005, Vol.15(8), pp.1997-2001 [Peer Reviewed Journal]

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81
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Amidines as amide bond replacements in VLA-4 antagonists

Kamenecka, Theodore M ; Park, You-Jung ; Lin, Linus S ; de Laszlo, Stephen ; Mccauley, Ermengilda D ; Van Riper, Gail ; Egger, Linda ; Kidambi, Usha ; Mumford, Richard A ; Tong, Sharon ; Tang, Wei ; Colletti, Adria ; Teffera, Yohannes ; Stearns, Ralph ; Maccoss, Malcolm ; Schmidt, John A ; Hagmann, William K

Bioorganic & Medicinal Chemistry Letters, 03 May 2004, Vol.14(9), pp.2323-2326 [Peer Reviewed Journal]

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82
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Syntheses and SAR studies of 4-(heteroarylpiperdin-1-yl-methyl)-pyrrolidin-1-yl-acetic acid antagonists of the human CCR5 chemokine receptor

Shankaran, K ; Donnelly, Karla L ; Shah, Shrenik K ; Guthikonda, Ravindra N ; Maccoss, Malcolm ; Mills, Sander G ; Gould, Sandra L ; Malkowitz, Lorraine ; Siciliano, Salvatore J ; Springer, Martin S ; Carella, Anthony ; Carver, Gwen ; Hazuda, Daria ; Holmes, Karen ; Kessler, Joseph ; Lineberger, Janet ; Miller, Michael D ; Emini, Emilio A ; Schleif, William A

Bioorganic & Medicinal Chemistry Letters, 2004, Vol.14(13), pp.3419-3424 [Peer Reviewed Journal]

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83
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1,3,4-Trisubstituted pyrrolidine CCR5 receptor antagonists. Part 3: polar functionality and its effect on anti-HIV-1 activity

Hale, Jeffrey J ; Budhu, Richard J ; Mills, Sander G ; Maccoss, Malcolm ; Gould, Sandra L ; Demartino, Julie A ; Springer, Martin S ; Siciliano, Salvatore J ; Malkowitz, Lorraine ; Schleif, William A ; Hazuda, Daria ; Miller, Michael ; Kessler, Joseph ; Danzeisen, Renee ; Holmes, Karen ; Lineberger, Janet ; Carella, Anthony ; Carver, Gwen ; Emini, Emilio A

Bioorganic & Medicinal Chemistry Letters, 21 October 2002, Vol.12(20), pp.2997-3000 [Peer Reviewed Journal]

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84
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N-(Arylacetyl)-biphenylalanines as Potent VLA-4 Antagonists

Li, Bing ; de Laszlo, Stephen E ; Kamenecka, Theodore M ; Kopka, Ihor E ; Durette, Philippe L ; Lanza, Jr, Thomas ; Maccoss, Malcolm ; Tong, Sharon ; Mumford, Richard A ; Mccauley, Ermengilda D ; Van Riper, Gail ; Schmidt, John A ; Hagmann, William K

Bioorganic & Medicinal Chemistry Letters, 2002, Vol.12(16), pp.2141-2144 [Peer Reviewed Journal]

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85
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N-Aryl-prolyl-dipeptides as potent antagonists of VLA-4

Kamenecka, Theodore M ; Lanza, Jr, Thomas ; de Laszlo, Stephen E ; Li, Bing ; Mccauley, Ermengilda D ; Van Riper, Gail ; Egger, Linda A ; Kidambi, Usha ; Mumford, Richard A ; Tong, Sharon ; Maccoss, Malcolm ; Schmidt, John A ; Hagmann, William K

Bioorganic & Medicinal Chemistry Letters, 2002, Vol.12(16), pp.2205-2208 [Peer Reviewed Journal]

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