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Discovery of highly potent and efficacious MC4R agonists with spiroindane N-Me-1,2,4-triazole privileged structures for the treatment of obesity

He, Shuwen ; Ye, Zhixiong ; Dobbelaar, Peter H. ; Bakshi, Raman K. ; Hong, Qingmei ; Dellureficio, James P. ; Sebhat, Iyassu K. ; Guo, Liangqin ; Liu, Jian ; Jian, Tianying ; Lai, Yingjie ; Franklin, Christopher L. ; Reibarkh, Mikhail ; Holmes, Mark A. ; Weinberg, David H. ; Macneil, Tanya ; Tang, Rui ; Tamvakopoulos, Constantin ; Peng, Qianping ; Miller, Randy R. ; Stearns, Ralph A. ; Chen, Howard Y. ; Chen, Airu S. ; Strack, Alison M. ; Fong, Tung M. ; Wyvratt, Matthew J. ; Nargund, Ravi P.

Bioorganic & Medicinal Chemistry Letters, 2010, Vol.20(22), pp.6524-6532 [Peer Reviewed Journal]

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