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Discovery and activity of (1 R,4 S,6 R)- N-[(1 R)-2-[4-cyclohexyl-4-[[(1,1-dimethylethyl)amino]carbonyl]-1-piperidinyl]-1-[(4-fluorophenyl)methyl]-2-oxoethyl]-2-methyl-2-azabicyclo[2.2.2]octane-6-carboxamide (3, RY764), a potent and selective melanocortin subtype-4 receptor agonist

Ye, Zhixiong ; Guo, Liangqin ; Barakat, Khaled J. ; Pollard, Patrick G. ; Palucki, Brenda L. ; Sebhat, Iyassu K. ; Bakshi, Raman K. ; Tang, Rui ; Kalyani, Rubana N. ; Vongs, Aurawan ; Chen, Airu S. ; Chen, Howard Y. ; Rosenblum, Charles I. ; Macneil, Tanya ; Weinberg, David H. ; Peng, Qianping ; Tamvakopoulos, Constantin ; Miller, Randy R. ; Stearns, Ralph A. ; Cashen, Doreen E. ; Martin, William J. ; Metzger, Joseph M. ; Strack, Alison M. ; Macintyre, D. Euan ; Van Der Ploeg, Lex H.T. ; Patchett, Arthur A. ; Wyvratt, Matthew J. ; Nargund, Ravi P.

Bioorganic & Medicinal Chemistry Letters, 2005, Vol.15(15), pp.3501-3505 [Peer Reviewed Journal]

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