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The Total Synthesis of Proteasome Inhibitors TMC‐95A and TMC‐95B: Discovery of a New Method To Generate cis ‐Propenyl Amides

Lin, Songnian ; Danishefsky, Samuel J.

Angewandte Chemie International Edition, 01 February 2002, Vol.41(3), pp.512-515 [Peer Reviewed Journal]

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  • Title:
    The Total Synthesis of Proteasome Inhibitors TMC‐95A and TMC‐95B: Discovery of a New Method To Generate cis ‐Propenyl Amides
  • Author: Lin, Songnian ; Danishefsky, Samuel J.
  • Description: (see scheme, left) were the key steps in the first total synthesis of the title compounds, which only differ in stereochemistry at the remote C36 stereocenter. Other key steps include a Suzuki biaryl construction, a diastereofacial dihydroxylation reaction, and a macrolactamization.
  • Is Part Of: Angewandte Chemie International Edition, 01 February 2002, Vol.41(3), pp.512-515
  • Identifier: ISSN: 1433-7851 ; E-ISSN: 1521-3773 ; DOI: 10.1002/1521-3773(20020201)41:3<512::AID-ANIE512>3.0.CO;2-R
  • Subjects: Biaryls ; Inhibitors ; Macrolactamization ; Rearrangement ; Total Synthesis
  • Language: English
  • Source: John Wiley & Sons, Inc.

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