skip to main content
Language:
Search Limited to: Search Limited to: Resource type Show Results with: Show Results with: Index

Glicentin‐related pancreatic polypeptide inhibits glucose‐stimulated insulin secretion from the isolated pancreas of adult male rats

Whiting, Lynda ; Stewart, Kevin W. ; Hay, Deborah L. ; Harris, Paul W. ; Choong, Yee S. ; Phillips, Anthony R. J. ; Brimble, Margaret A. ; Cooper, Garth J. S.

Physiological Reports, December 2015, Vol.3(12), pp.n/a-n/a [Peer Reviewed Journal]

Full text available

Citations Cited by
  • Title:
    Glicentin‐related pancreatic polypeptide inhibits glucose‐stimulated insulin secretion from the isolated pancreas of adult male rats
  • Author: Whiting, Lynda ; Stewart, Kevin W. ; Hay, Deborah L. ; Harris, Paul W. ; Choong, Yee S. ; Phillips, Anthony R. J. ; Brimble, Margaret A. ; Cooper, Garth J. S.
  • Description: Peptides derived from the glucagon gene , for example, glucagon and glucagon‐like peptide 1 (‐1), act as physiological regulators of fuel metabolism and are thus of major interest in the pathogenesis of diseases, such as type‐2 diabetes and obesity, and their therapeutic management. Glicentin‐related pancreatic polypeptide () is a further, 30 amino acid derived peptide identified in human, mouse, rat, and pig. However, the potential glucoregulatory function of this peptide is largely unknown. Here, we synthesized rat () and a closely related peptide, rat ‐like peptide (‐), and investigated their actions in the liver and pancreas of adult male rats by employing isolated‐perfused organ preparations. Rat and ‐ did not affect glucose output from the liver, but both elicited potent inhibition of glucose‐stimulated insulin secretion () from the rat pancreas. This action is unlikely to be mediated by glucagon or ‐1 receptors, as and ‐ did not stimulate cyclic adenosine monophosphate () production from the glucagon or ‐1 receptors, nor did they antagonize glucagon‐ or ‐1‐stimulated ‐production at either receptor. and ‐ may be novel regulators of insulin secretion, acting through an as‐yet undefined receptor. Peptides derived from the glucagon gene Gcg, for example glucagon and glucagon‐like peptide 1 (‐1), act as physiological regulators of fuel metabolism and are thus of major interest in the pathogenesis of diseases such as type‐2 diabetes and obesity. Glicentin‐related pancreatic polypeptide () is another 30 amino‐acid Gcg‐derived peptide identified in human, mouse, rat and pig, whose potential glucoregulatory function is largely unknown. We synthesized rat () and a closely related peptide, rat ‐like peptide (‐), investigated their actions in the liver and pancreas of adult male rats and suggest that and ‐ may be novel regulators of insulin secretion, acting through an as‐yet undefined receptor.
  • Is Part Of: Physiological Reports, December 2015, Vol.3(12), pp.n/a-n/a
  • Identifier: ISSN: 2051-817X ; E-ISSN: 2051-817X ; DOI: 10.14814/phy2.12638
  • Subjects: Glp ‐1 ; Glucagon ; Grpp ; Gsis ; Proglucagon

Searching Remote Databases, Please Wait