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Geniposide protects pancreatic β cells from high glucose‐mediated injury by activation of AMP‐activated protein kinase

Liu, Chunyan ; Hao, Yanan ; Yin, Fei ; Zhang, Yonglan ; Liu, Jianhui

Cell Biology International, May 2017, Vol.41(5), pp.544-554 [Peer Reviewed Journal]

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  • Title:
    Geniposide protects pancreatic β cells from high glucose‐mediated injury by activation of AMP‐activated protein kinase
  • Author: Liu, Chunyan ; Hao, Yanan ; Yin, Fei ; Zhang, Yonglan ; Liu, Jianhui
  • Description: Our previous works indicated that geniposide could regulate glucose-stimulated insulin secretion (GSIS), and improved chronic high glucose-induced dysfunctions in pancreatic β cells, but the molecular mechanisms remain largely unknown. In the present study, we investigated the role of 5'-AMP-activated protein kinase (AMPK) in high glucose induced cell injury and explored the associated molecular mechanisms in rat INS-1 pancreatic β cells. Data suggested that geniposide obviously prevented the cell damage induced by high (25 mM) glucose in INS-1 cells, which increased the protein levels of cell apoptosis-associated enzymes, including heme oxygenase-1 (HO-1), and Bcl-2, but apparently attenuated the protein level of Bax, an apoptotic protein. In addition, Compound C, an AMPK inhibitor, remarkably inhibited the effects of geniposide on the protein levels of HO-1, Bcl-2, and Bax, but AICAR, an AMPK activator, potentiated the role of geniposide on the protein levels of HO-1, Bcl-2, and Bax....
  • Is Part Of: Cell Biology International, May 2017, Vol.41(5), pp.544-554
  • Identifier: ISSN: 1065-6995 ; E-ISSN: 1095-8355 ; DOI: 10.1002/cbin.10758
  • Subjects: 5′‐Amp‐Activated Protein Kinase Ampk ; Bax ; Bcl‐2 ; Caspase‐3 ; Geniposide ; Glucose‐Stimulated Insulin Secretion Gsis

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