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Discovery of a piperazine urea based compound as a potent, selective, orally bioavailable melanocortin subtype-4 receptor partial agonist

Hong, Qingmei ; Bakshi, Raman K. ; Palucki, Brenda L. ; Park, Min K. ; Ye, Zhixiong ; He, Shuwen ; Pollard, Patrick G. ; Sebhat, Iyassu K. ; Liu, Jian ; Guo, Liangqin ; Cashen, Doreen E. ; Martin, William J. ; Weinberg, David H. ; Macneil, Tanya ; Tang, Rui ; Tamvakopoulos, Constantin ; Peng, Qianping ; Miller, Randy R. ; Stearns, Ralph A. ; Chen, Howard Y. ; Chen, Airu S. ; Strack, Alison M. ; Fong, Tung M. ; Macintyre, D. Euan ; Wyvratt, Matthew J. ; Nargund, Ravi P.

Bioorganic & Medicinal Chemistry Letters, 2011, Vol.21(8), pp.2330-2334 [Peer Reviewed Journal]

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