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Mechanism of Hypertriglyceridemia in Dahl Rats

Mondon, E., Carl ; Plato, A., Peggy ; Dallʼaglio, A., Elizabetta ; Sztalryd, A., Carole ; Reaven, A., Gerald

Hypertension, 1993, Vol.21(3), pp.373-379 [Peer Reviewed Journal]

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  • Title:
    Mechanism of Hypertriglyceridemia in Dahl Rats
  • Author: Mondon, E., Carl ; Plato, A., Peggy ; Dallʼaglio, A., Elizabetta ; Sztalryd, A., Carole ; Reaven, A., Gerald
  • Description: : Plasma triglyceride concentrations were shown to be higher in hypertensive (153±2 mm Hg) male Dahl salt-sensitive rats than in control Sprague-Dawley rats (122±2 mm Hg). These differences in triglyceride concentrations were seen when blood was drawn at 9 am from unfasted animals (229±27 versus 111±8 mg/dL), at 1 pm after a 4-hour fast (186±13 versus 88±4 mg/dL), or at 9 am after a 13-hour fast (151±6 versus 90±6 mg/dL), all p<0.001. Total triglyceride secretion was also compared in groups of rats by determining the increment in plasma triglyceride concentration for 2 hours after blocking triglyceride removal from plasma by injecting Triton. Studies performed at 1 pm and 9 am, after the 4- and 13-hour fast, demonstrated that total triglyceride secretion was greater (p<0.05) in Dahl rats only when studied at 1 pm. Direct estimates of hepatic triglyceride secretion at 1 pm also demonstrated a significant (p<0.02) increase in secretion rate by perfused livers from Dahl rats, due in part to their increased liver size. In addition, removal of prelabeled very low density lipoprotein-triglyceride in the intact rat was significantly (p<0.05) decreased in Dahl rats. Lipoprotein Iipase activity measured in skeletal muscle, heart, and adipose tissue was also significantly decreased at 9 am and 1 pm (after 0 and 4 hours of fasting) in tissue from Dahl rats. These data confirm that Dahl rats have higher plasma triglyceride concentrations than Sprague-Dawley rats. Since both total and hepatic triglyceride secretion were somewhat greater in Dahl rats, in association with a decrease in both removal of very low density lipoprotein from plasma and decreased muscle and adipose tissue lipoprotein lipase activity, it seems likely that hypertriglyceridemia in Dahl rats results from a combination of increased triglyceride secretion and decreased triglyceride removal. (Hypertension 1993;21:373-379)
  • Is Part Of: Hypertension, 1993, Vol.21(3), pp.373-379
  • Identifier: ISSN: 0194-911X
  • Subjects: Medicine

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