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Formation of eosinophilic and monocytic intradermal inflammatory sites in the dog by injection of human RANTES but not human monocyte chemoattractant protein 1, human macrophage inflammatory protein 1 alpha, or human interleukin 8

Meurer, R ; Van Riper, G ; Feeney, W ; Cunningham, P ; Hora, D ; Springer, M S ; Macintyre, D E ; Rosen, H

The Journal of experimental medicine, 01 December 1993, Vol.178(6), pp.1913-21 [Peer Reviewed Journal]

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  • Title:
    Formation of eosinophilic and monocytic intradermal inflammatory sites in the dog by injection of human RANTES but not human monocyte chemoattractant protein 1, human macrophage inflammatory protein 1 alpha, or human interleukin 8
  • Author: Meurer, R ; Van Riper, G ; Feeney, W ; Cunningham, P ; Hora, D ; Springer, M S ; Macintyre, D E ; Rosen, H
  • Description: Equilibrium binding studies on canine mononuclear and granulocytic cells allow the identification of a single high affinity receptor for the human C-C chemokine RANTES (dissociation constant, 14 +/- 8 pM), that, in contrast to the human RANTES receptor, has no affinity for human macrophage inflammatory protein 1 alpha (hMIP-1 alpha). A single intradermal injection of hRANTES in dog resulted in eosinophil- and macrophage-rich inflammatory sites within 4 h. Cell infiltration peaked at 16-24 h after hRANTES injection. There was histological evidence of intravascular activation of eosinophils at 4 h, although eosinophils in the vasculature and interstitium contained apparently intact granules. Monocytes were the predominant cells adherent to venular endothelium at 16-24 h. Human MIP-1 alpha elicited no response in canine dermis, whereas monocyte chemoattractant protein 1 caused mild perivascular cuffing with monocytes. In contrast, human interleukin 8 induced a neutrophilic dermal infiltrate that was maximal by 4 h after challenge. This provides the first direct evidence in vivo that RANTES has significant proinflammatory activity and, in addition, could be a mediator in atopic pathologies characterized by eosinophilic and monocytic inflammatory responses.
  • Is Part Of: The Journal of experimental medicine, 01 December 1993, Vol.178(6), pp.1913-21
  • Identifier: ISSN: 0022-1007 ; PMID: 7504053 Version:1
  • Subjects: Receptors, Chemokine ; Cytokines -- Pharmacology ; Eosinophils -- Immunology ; Inflammation -- Chemically Induced ; Interleukin-8 -- Pharmacology ; Lymphokines -- Pharmacology ; Monocytes -- Immunology ; Monokines -- Pharmacology ; Proteins -- Pharmacology
  • Language: English

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