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Acute effects of endothelin receptor antagonists on hepatic hemodynamics of cirrhotic and noncirrhotic rats

Cavasin, Maria A ; Semus, Hillary ; Pitts, Kelly ; Peng, Yanyu ; Sandoval, Jennifer ; Chapo, Joseph ; Plato, Craig F

Canadian journal of physiology and pharmacology, June 2010, Vol.88(6), pp.636-43 [Peer Reviewed Journal]

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  • Title:
    Acute effects of endothelin receptor antagonists on hepatic hemodynamics of cirrhotic and noncirrhotic rats
  • Author: Cavasin, Maria A ; Semus, Hillary ; Pitts, Kelly ; Peng, Yanyu ; Sandoval, Jennifer ; Chapo, Joseph ; Plato, Craig F
  • Description: Hepatic and circulating endothelin-1 (ET-1) are increased in patients with cirrhosis and in cirrhotic animals. However, the distinct roles of ET receptor subtypes ETA and ETB in cirrhosis and portal hypertension (PHT) have not been clearly elucidated. Thus, we studied the effects of selective ET-1 antagonists (ETA-ant or ETB-ant) and nonselective ET-1 antagonist (ETA/B-ant) on hepatic hemodynamics in cirrhotic rats. Liver fibrosis and PHT were induced by complete bile duct ligation (BDL) in rats. Two weeks after BDL or sham surgery, hemodynamic responses were measured during intraportal infusion of incremental doses of the following ET-ants: (i) BQ-123, (ii) BQ-788, and (iii) bosentan. After equilibration with vehicle, doses of ET-ants were infused for 30 min periods, and steady-state systemic and hepatic hemodynamics, portal venous pressure (PVP), and hepatic blood flow (HBF) were measured. BDL induced significant PHT and elevated concentrations of plasma ET-1 compared with sham. ETA-ant...
  • Is Part Of: Canadian journal of physiology and pharmacology, June 2010, Vol.88(6), pp.636-43
  • Identifier: E-ISSN: 1205-7541 ; PMID: 20628429 Version:1 ; DOI: 10.1139/Y10-038
  • Subjects: Endothelin Receptor Antagonists ; Hemodynamics -- Drug Effects ; Liver -- Blood Supply ; Liver Cirrhosis -- Physiopathology
  • Language: English
  • Source: MEDLINE/PubMed (U.S. National Library of Medicine)

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