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Regulation of atrial natriuretic peptide secretion by a novel Ras-like protein

Rybkin, Igor I ; Kim, Mi-Sung ; Bezprozvannaya, Svetlana ; Qi, Xiaoxia ; Richardson, James A ; Plato, Craig F ; Hill, Joseph A ; Bassel-Duby, Rhonda ; Olson, Eric N

The Journal of cell biology, 05 November 2007, Vol.179(3), pp.527-37 [Peer Reviewed Journal]

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  • Title:
    Regulation of atrial natriuretic peptide secretion by a novel Ras-like protein
  • Author: Rybkin, Igor I ; Kim, Mi-Sung ; Bezprozvannaya, Svetlana ; Qi, Xiaoxia ; Richardson, James A ; Plato, Craig F ; Hill, Joseph A ; Bassel-Duby, Rhonda ; Olson, Eric N
  • Description: Atrial cardiomyocytes, neurons, and endocrine tissues secrete neurotransmitters and peptide hormones via large dense-core vesicles (LDCVs). We describe a new member of the Ras family of G-proteins, named RRP17, which is expressed specifically in cardiomyocytes, neurons, and the pancreas. RRP17 interacts with Ca(2+)-activated protein for secretion-1 (CAPS1), one of only a few proteins known to be associated exclusively with LDCV exocytosis. Ectopic expression of RRP17 in cardiomyocytes enhances secretion of atrial natriuretic peptide (ANP), a regulator of blood pressure and natriuresis. Conversely, genetic deletion of RRP17 in mice results in dysmorphic LDCVs, impaired ANP secretion, and hypertension. These findings identify RRP17 as a component of the cellular machinery involved in regulated secretion within the heart and potential mediator of the endocrine influence of the heart on other tissues.
  • Is Part Of: The Journal of cell biology, 05 November 2007, Vol.179(3), pp.527-37
  • Identifier: ISSN: 0021-9525 ; PMID: 17984325 Version:1
  • Subjects: Gene Expression Regulation ; Atrial Natriuretic Factor -- Metabolism ; Gtp-Binding Proteins -- Metabolism ; Ras Proteins -- Metabolism
  • Language: English
  • Source: MEDLINE/PubMed (U.S. National Library of Medicine)
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