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Increased serotonin release in mice frontal cortex and hippocampus induced by acute physiological stressors

Fujino, Kaoru ; Yoshitake, Takashi ; Inoue, Osamu ; Ibii, Nobuhiro ; Kehr, Jan ; Ishida, Junichi ; Nohta, Hitoshi ; Yamaguchi, Masatoshi

Neuroscience letters, 01 March 2002, Vol.320(1-2), pp.91-5 [Peer Reviewed Journal]

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  • Title:
    Increased serotonin release in mice frontal cortex and hippocampus induced by acute physiological stressors
  • Author: Fujino, Kaoru ; Yoshitake, Takashi ; Inoue, Osamu ; Ibii, Nobuhiro ; Kehr, Jan ; Ishida, Junichi ; Nohta, Hitoshi ; Yamaguchi, Masatoshi
  • Description: The effects of acute physiological stressors (5 s tail pinch, handling and forced swimming at +25 and +5 degrees C for 3 min each) on serotonin (5-HT) release in the mouse brain were investigated using in vivo microdialysis. The extracellular 5-HT levels were determined by a newly developed highly-sensitive and selective high-performance liquid chromatography method based on derivatization with benzylamine and fluorescence detection. The basal levels of 5-HT in 3 min microdialysates from the ventral hippocampus and frontal cortex were 0.68+/-0.21 and 0.75+/-0.28 fmol/6 microl (n=24), respectively. All three stressors caused an immediate, significant and reversible increase (handling: 150%; swimming: 240%) of extracellular 5-HT levels in both brain structures, suggesting a more dynamic role played by the serotonergic system in response to acute stress.
  • Is Part Of: Neuroscience letters, 01 March 2002, Vol.320(1-2), pp.91-5
  • Identifier: ISSN: 0304-3940 ; PMID: 11849771 Version:1
  • Subjects: Extracellular Space -- Metabolism ; Frontal Lobe -- Metabolism ; Hippocampus -- Metabolism ; Neurons -- Metabolism ; Serotonin -- Metabolism ; Stress, Physiological -- Metabolism
  • Language: English
  • Source: MEDLINE/PubMed (U.S. National Library of Medicine)

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