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Novel succinct routes to quinoxalines and 2-benzimidazolylquinoxalines via the Ugi reaction

Ayaz, Muhammad ; Xu, Zhigang ; Hulme, Christopher

Tetrahedron Letters, 04 June 2014, Vol.55(23), pp.3406-3409 [Peer Reviewed Journal]

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  • Title:
    Novel succinct routes to quinoxalines and 2-benzimidazolylquinoxalines via the Ugi reaction
  • Author: Ayaz, Muhammad ; Xu, Zhigang ; Hulme, Christopher
  • Description: This Letter reveals a unique, user-friendly, concise two-step, one-pot protocol for the synthesis of highly substituted quinoxalines. Conducting the Ugi reaction with appropriately functionalized classical Ugi reagents with subsequent acid treatment of the Ugi adduct affords collections of diversified quinoxalines in good to excellent yields. The methodology exploits what may be viewed as a ‘convertible carboxylic acid’, which in addition may be captured in an intramolecular sense to generate structurally complex 2-benzimidazolylquinoxalines in a mere two steps.
  • Is Part Of: Tetrahedron Letters, 04 June 2014, Vol.55(23), pp.3406-3409
  • Identifier: ISSN: 0040-4039 ; E-ISSN: 1873-3581 ; DOI: 10.1016/j.tetlet.2014.04.013
  • Subjects: Ugi Reaction ; Post-Condensation Modifications ; Quinoxaline ; Benzimidazole ; Acyl Transfer ; Chemistry
  • Language: English

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