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Determinants and incidence of depression in multiple sclerosis: A prospective cohort study

Berzins, S.A ; Bulloch, A.G ; Burton, J.M ; Dobson, K.S ; Fick, G.H ; Patten, S.B

Journal of Psychosomatic Research, August 2017, Vol.99, pp.169-176 [Peer Reviewed Journal]

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  • Title:
    Determinants and incidence of depression in multiple sclerosis: A prospective cohort study
  • Author: Berzins, S.A ; Bulloch, A.G ; Burton, J.M ; Dobson, K.S ; Fick, G.H ; Patten, S.B
  • Description: To estimate the incidence and explore potential determinants of incidence of depression in MS. A prospective cohort study used a sample of 192 patients from the southern Alberta MS clinic registry. Participants completed baseline risk factor assessment questionnaires using either online, mail or telephone surveys, and completed the Patient Health Questionnaire every 2 weeks for 6 months to assess depressive symptoms in real time. Risk factors assessed included biopsychosocial variables such as socioeconomic status, illness-related factors, childhood risk factors, psychosocial factors, and health behaviors. Cox proportional hazard models were fit to estimate predictors of incidence. 2-week incidence of depression for females was 0.019 (95% CI 0.013–0.029) and for males was 0.044 (0.026–0.074). Strongest predictor of depression incidence risk included fatigue impact, low mobility, resiliency, self-esteem,...
  • Is Part Of: Journal of Psychosomatic Research, August 2017, Vol.99, pp.169-176
  • Identifier: ISSN: 0022-3999 ; E-ISSN: 1879-1360 ; DOI: 10.1016/j.jpsychores.2017.06.012
  • Subjects: Depression ; Multiple Sclerosis ; Incidence ; Risk Factors ; Determinants ; Cohort Study
  • Language: English

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