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P295 APOE polymorphism and cortical plasticity are independently associated with cognitive decline in Alzheimer’s disease

Lorenzo, F.Di ; Motta, C ; Ponzo, V ; Bonnì, S ; Martorana, A ; Koch, G

Clinical Neurophysiology, March 2017, Vol.128(3), pp.e154-e154 [Peer Reviewed Journal]

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  • Title:
    P295 APOE polymorphism and cortical plasticity are independently associated with cognitive decline in Alzheimer’s disease
  • Author: Lorenzo, F.Di ; Motta, C ; Ponzo, V ; Bonnì, S ; Martorana, A ; Koch, G
  • Description: APOE E4 allele associates not only with AD risk and a lower age onset, but also with faster cognitive decline and greater cerebral atrophy, suggesting a key role of this polymorphism in modulating both disease risk and clinical outcome. In this study we investigated the correlation between cognitive decline, motor cortical plasticity and cerebrospinal fluid (CSF) biomarkers profile of AD patients divided by APOE polymorphism in E4 allele carriers (E4) and homozygous E3 carriers. A monophasic Magstim 200 device was used to deliver intermitted/continuous theta burst stimulation (iTBS/cTBS) protocols. ELISA was used for determination of CSF biomarkers level. Forty-one AD patients underwent lumbar puncture for CSF withdrawal, blood screening for APOE polymorphism, stimulation protocols applied over the primary motor cortex and mini mental state examination (MMSE) at baseline and at 6-, 12- and 18-months. No difference was found...
  • Is Part Of: Clinical Neurophysiology, March 2017, Vol.128(3), pp.e154-e154
  • Identifier: ISSN: 1388-2457 ; E-ISSN: 1872-8952 ; DOI: 10.1016/j.clinph.2016.10.403
  • Subjects: Medicine
  • Language: English

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