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P271 Impaired spike timing dependent cortico-cortical plasticity in Alzheimer’s disease patients

Di Lorenzo, F ; Ponzo, V ; Caltagirone, C ; Martorana, A ; Koch, G

Clinical Neurophysiology, March 2017, Vol.128(3), pp.e143-e143 [Peer Reviewed Journal]

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  • Title:
    P271 Impaired spike timing dependent cortico-cortical plasticity in Alzheimer’s disease patients
  • Author: Di Lorenzo, F ; Ponzo, V ; Caltagirone, C ; Martorana, A ; Koch, G
  • Description: Mechanisms of cortical plasticity have been widely investigated in Alzheimer’s disease (AD) patients with TMS protocols, showing a clear impairment of Long-Term Potentiation (LTP) cortical-like plasticity and a relative sparing of Long Term Depression (LTD) mechanisms. Recently a new TMS protocol, investigating the connections between posterior parietal cortex (PPC) and primary motor cortex (M1), elicited in a bidirectional way LTP and LTD effects. We investigated mechanisms of spike-timing dependent plasticity in AD patients and the effects of the modulation of PPC-M1 pathway on cholinergic transmission, greatly impaired in AD patients. Twelve AD patients and eight age-matched healthy subjects (HS) were evaluated. We used bifocal TMS to repeatedly activate the connections between the PPC and M1 of the left-dominant hemisphere. PPC TMS preceded or followed the M1 stimulation by 5ms, respectively PAS +5 and PAS −5. To best activate the ipsilateral...
  • Is Part Of: Clinical Neurophysiology, March 2017, Vol.128(3), pp.e143-e143
  • Identifier: ISSN: 1388-2457 ; E-ISSN: 1872-8952 ; DOI: 10.1016/j.clinph.2016.10.381
  • Subjects: Medicine
  • Language: English

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