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T017 Hebbian plasticity in the parieto-frontal network

Koch, G

Clinical Neurophysiology, March 2017, Vol.128(3), pp.e5-e6 [Peer Reviewed Journal]

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  • Title:
    T017 Hebbian plasticity in the parieto-frontal network
  • Author: Koch, G
  • Description: Transcranial magnetic stimulation (TMS) provides a unique opportunity to test the causal neurophysiological interactions between interconnnected brain areas. This can be done by applying two coils over two different brain areas and deliver subsequent TMS pulses with a certain time interval in the range of few milliseconds (dual-site TMS). In these paradigms, a conditioning stimulus (CS) is first used to activate putative pathways to the motor cortex (M1) from the site of stimulation, while a second, test stimulus (TS), delivered a few ms later probes any changes in excitability that are produced by the input. Dual-site TMS can be used to investigate mechanisms of spike timing dependent plasticity within a certain network. LTP- and LTD-like effects can be induced in M1 following the repeated application of paired pulses over interconnected areas such as contralateral M1, ventral premotor cortex, supplementary motor area or the posterior parietal cortex (PPC). A crucial question...
  • Is Part Of: Clinical Neurophysiology, March 2017, Vol.128(3), pp.e5-e6
  • Identifier: ISSN: 1388-2457 ; E-ISSN: 1872-8952 ; DOI: 10.1016/j.clinph.2016.10.116
  • Subjects: Medicine
  • Language: English

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