skip to main content
Language:
Search Limited to: Search Limited to: Resource type Show Results with: Show Results with: Index

69. Impaired spike timing dependent cortico-cortical plasticity in Alzheimer’s Disease patients

Di Lorenzo, F ; Martorana, A ; Ponzo, V ; Bonní, S ; Koch, G

Clinical Neurophysiology, December 2016, Vol.127(12), pp.e340-e340 [Peer Reviewed Journal]

Full text available

View all versions
Citations Cited by
  • Title:
    69. Impaired spike timing dependent cortico-cortical plasticity in Alzheimer’s Disease patients
  • Author: Di Lorenzo, F ; Martorana, A ; Ponzo, V ; Bonní, S ; Koch, G
  • Description: Mechanisms of cortical plasticity have been widely investigated in Alzheimer’s Disease (AD) patients with transcranial magnetic stimulation (TMS) protocols as Theta Burst Stimulation, showing a clear impairment of Long-Term Potentiation (LTP) cortical-like plasticity and a relative sparing of Long Term Depression (LTD) mechanisms. Recently a new TMS protocol, investigating the connections between posterior parietal cortex (PPC) and primary motor cortex (M1), elicited in a bidirectional way LTP and LTD effects. The aim of our study is to investigate mechanisms of spike-timing dependent plasticity in Alzheimer’s disease patients and furthermore to investigate the effects of the modulation of PPC-M1 pathway on cholinergic transmission, greatly impaired in AD patients. Twelve AD patients and eight age-matched healthy subjects were evaluated. We used bifocal TMS to repeatedly activate the connection between the PPC and M1 of the left-dominant hemisphere....
  • Is Part Of: Clinical Neurophysiology, December 2016, Vol.127(12), pp.e340-e340
  • Identifier: ISSN: 1388-2457 ; E-ISSN: 1872-8952 ; DOI: 10.1016/j.clinph.2016.10.081
  • Subjects: Medicine
  • Language: English
  • Source: ScienceDirect Journals (Elsevier)

Searching Remote Databases, Please Wait