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Cerebellar tDCS in patients with ataxic disorders: A double-blind, randomized, crossover, sham-controlled study

Benussi, A ; Koch, G ; Cotelli, M ; Padovani, A ; Borroni, B

Clinical Neurophysiology, March 2016, Vol.127(3), pp.e23-e24 [Peer Reviewed Journal]

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  • Title:
    Cerebellar tDCS in patients with ataxic disorders: A double-blind, randomized, crossover, sham-controlled study
  • Author: Benussi, A ; Koch, G ; Cotelli, M ; Padovani, A ; Borroni, B
  • Description: Cerebellar ataxias represent a group of disabling disorders for which we currently lack effective therapies. The present study investigated whether anodal (tDCS) over the cerebellar cortex could improve cerebellar symptoms in patients with ataxia. Nineteen patients with ataxic disorders were enrolled. The SARA (Scale for the Assessment and Rating of Ataxia) and ICARS (International Cooperative Ataxia Rating Scale), the 9-hole peg test (9HPT) and the 8-meter walking time (8MW) were performed pre- and post-double-blind, randomized, sham or anodal tDCS, with crossover treatment after one week. There was a significant interaction between treatment and time on SARA, ICARS, 9HPT and 8MW (p0.001). At the end of the trials, all scores were significantly different in the sham trial compared to the intervention trial, with a mean difference of 1.40 in SARA score, 4.37 in ICARS score, 1.37 sec in 9HPT and 1.42 sec in 8MW. There was a negative correlation...
  • Is Part Of: Clinical Neurophysiology, March 2016, Vol.127(3), pp.e23-e24
  • Identifier: ISSN: 1388-2457 ; E-ISSN: 1872-8952 ; DOI: 10.1016/j.clinph.2015.11.066
  • Subjects: Medicine
  • Language: English
  • Source: ScienceDirect Journals (Elsevier)

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