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Identification of Unique VLA-4 Antagonists from a Combinatorial Library

de Laszlo, Stephen E ; Li, Bing ; Mccauley, Ermengilda ; Van Riper, Gail ; Hagmann, William K

Bioorganic & Medicinal Chemistry Letters, 2002, Vol.12(4), pp.685-688 [Peer Reviewed Journal]

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  • Title:
    Identification of Unique VLA-4 Antagonists from a Combinatorial Library
  • Author: de Laszlo, Stephen E ; Li, Bing ; Mccauley, Ermengilda ; Van Riper, Gail ; Hagmann, William K
  • Description: A combinatorial library of 28 pools of 180 compounds (345 diastereomers) was designed and prepared in support of the delineation of the SAR of two prototypical VLA-4 antagonists. Deconvolution of the active pools led to the identification of three novel series of VLA-4 antagonists with low nanomolar potencies.
  • Is Part Of: Bioorganic & Medicinal Chemistry Letters, 2002, Vol.12(4), pp.685-688
  • Identifier: ISSN: 0960-894X ; E-ISSN: 1464-3405 ; DOI: 10.1016/S0960-894X(01)00833-2
  • Subjects: Medicine ; Chemistry ; Anatomy & Physiology
  • Language: English

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