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Alpha-2 and beta-adrenergic receptors mediate NE's biphasic effects on rat thick ascending limb chloride flux

Plato, C F

American journal of physiology. Regulatory, integrative and comparative physiology, September 2001, Vol.281(3), pp.R979-86 [Peer Reviewed Journal]

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  • Title:
    Alpha-2 and beta-adrenergic receptors mediate NE's biphasic effects on rat thick ascending limb chloride flux
  • Author: Plato, C F
  • Description: The sympathetic neurotransmitter norepinephrine (NE) influences renal sodium excretion via activation of adrenergic receptors. The thick ascending limb (THAL) possesses both alpha-2 and beta-adrenergic receptors. However, the role(s) different adrenergic receptors play in how isolated THALs respond to NE are unclear. We tested the hypothesis that both alpha-2 and beta-adrenergic receptors are responsive to NE in the isolated THAL, with alpha-2 receptors inhibiting and beta-receptors stimulating chloride flux (J(Cl)). THALs from male Sprague-Dawley rats were perfused in vitro, and the effects of 1) incremental NE, 2) the alpha-2 agonist clonidine, and 3) the beta-agonist isoproterenol on J(Cl) were measured. Low concentrations (0.1 nM) of NE decreased J(Cl) from a rate of 114.2 +/- 8.1 to 93.5 +/- 14.6 pmol. mm(-1). min(-1) (P < 0.05), with the nadir occurring at 1 nM (67.7 +/- 8.8 pmol. mm(-1). min(-1); P < 0.05). In contrast, greater concentrations of NE significantly increased J(Cl) from...
  • Is Part Of: American journal of physiology. Regulatory, integrative and comparative physiology, September 2001, Vol.281(3), pp.R979-86
  • Identifier: ISSN: 0363-6119 ; PMID: 11507016 Version:1
  • Subjects: Loop of Henle -- Drug Effects ; Norepinephrine -- Pharmacology ; Receptors, Adrenergic, Alpha-2 -- Metabolism ; Receptors, Adrenergic, Beta -- Metabolism
  • Language: English
  • Source: MEDLINE/PubMed (U.S. National Library of Medicine)

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