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Results of Long‐Term Experimental Studies on the Carcinogenicity of Methyl Alcohol and Ethyl Alcohol in Rats

Soffritti, Morando ; Belpoggi, Fiorella ; Cevolani, Daniela ; Guarino, Marina ; Padovani, Michela ; Maltoni, Cesare

Annals of the New York Academy of Sciences, December 2002, Vol.982(1), pp.46-69 [Peer Reviewed Journal]

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  • Title:
    Results of Long‐Term Experimental Studies on the Carcinogenicity of Methyl Alcohol and Ethyl Alcohol in Rats
  • Author: Soffritti, Morando ; Belpoggi, Fiorella ; Cevolani, Daniela ; Guarino, Marina ; Padovani, Michela ; Maltoni, Cesare
  • Description: Methyl alcohol was administered in drinking water supplied at doses of 20,000, 5,000, 500, or 0 ppm to groups of male and female Sprague‐Dawley rats 8 weeks old at the start of the experiment. Animals were kept under observation until spontaneous death. Ethyl alcohol was administered by ingestion in drinking water at a concentration of 10% or 0% supplied to groups of male and female Sprague‐Dawley rats; breeders and offspring were included in the experiment. Treatment started at 39 weeks of age (breeders), 7 days before mating, or from embryo life (offspring) and lasted until their spontaneous death. Under tested experimental conditions, methyl alcohol and ethyl alcohol were demonstrated to be carcinogenic for various organs and tissues. They must also be considered multipotential carcinogenic agents. In addition to causing other tumors, ethyl alcohol induced malignant tumors of the oral cavity, tongue, and lips. These sites have been shown to be target organs in man by epidemiologic studies.
  • Is Part Of: Annals of the New York Academy of Sciences, December 2002, Vol.982(1), pp.46-69
  • Identifier: ISSN: 0077-8923 ; E-ISSN: 1749-6632 ; DOI: 10.1111/j.1749-6632.2002.tb04924.x
  • Subjects: Methyl Alcohol ; Ethyl Alcohol ; Carcinogenicity ; Long‐Term Bioassay ; Rat
  • Source: John Wiley & Sons, Inc.

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