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Soy‐ghretropin, a novel ghrelin‐releasing peptide derived from soy protein

Nakato, Junya ; Aoki, Hayato ; Iwakura, Hiroshi ; Suzuki, Hideyuki ; Kanamoto, Ryuhei ; Ohinata, Kousaku

FEBS Letters, August 2016, Vol.590(16), pp.2681-2689 [Peer Reviewed Journal]

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  • Title:
    Soy‐ghretropin, a novel ghrelin‐releasing peptide derived from soy protein
  • Author: Nakato, Junya ; Aoki, Hayato ; Iwakura, Hiroshi ; Suzuki, Hideyuki ; Kanamoto, Ryuhei ; Ohinata, Kousaku
  • Description: We investigated exogenous secretagogues of ghrelin, which is an orexigenic hormone isolated from the stomach. We found that the tryptic digest of soy β‐conglycinin stimulated ghrelin secretion by the ghrelin‐producing cell line, 3‐1. We then identified a 22‐amino acid peptide corresponding to the β‐conglycinin α‐subunit(192–213) [βα(192–213)] from an active fraction separated by . The N‐terminal undecapeptide of βα(192–213), , exhibited ghrelin‐releasing activity at a lower dose than that of βα(192–213). We named ‘soy‐ghretropin’, which corresponds to βα(192–202). Neither [des‐NK]‐soy‐ghretropin nor [des‐R]‐soy‐ghretropin stimulated ghrelin secretion; hence, both the N‐ and C‐terminal structures of soy‐ghretropin were indispensable. Orally administered soy‐ghretropin increased plasma ghrelin levels and food intake . Soy‐ghretropin is the first exogenous ghrelin‐releasing peptide derived from food protein.
  • Is Part Of: FEBS Letters, August 2016, Vol.590(16), pp.2681-2689
  • Identifier: ISSN: 0014-5793 ; E-ISSN: 1873-3468 ; DOI: 10.1002/1873-3468.12306
  • Subjects: Food Protein ; Ghrelin ; Peptide ; Structure‐Activity Relationship

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