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Beneficial effect of long term intravenous bisphosphonate treatment of osteogenesis imperfecta

Åström, E ; Söderhäll, S

Archives of Disease in Childhood, May 2002, Vol.86(5), p.356 [Peer Reviewed Journal]

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  • Title:
    Beneficial effect of long term intravenous bisphosphonate treatment of osteogenesis imperfecta
  • Author: Åström, E ; Söderhäll, S
  • Description: Aim: To find an effective symptomatic treatment for osteogenesis imperfecta (OI). Methods: In a prospective observational study disodium pamidronate (APD) was given as monthly intravenous infusions to 28 children and adolescents (aged 0.6-18 years) with severe OI or a milder form of the disease, but with spinal compression fractures. Results: During treatment for 2-9 years, dual energy x ray absorptiometry measurements of the total body and of the lumbar spine showed a gradual increase in bone density. All bone metabolism variables in serum (alkaline phosphatase, osteocalcin, procollagen 1 C-terminal peptide, collagen 1 teleopeptide) and urine (deoxypyridinoline) indicated that there was a decrease in bone turnover. All patients experienced beneficial effects and the younger patients reported a major improvement in wellbeing, pain, and mobility without significant side effects. Vertebral remodelling was also seen. Conclusions: APD seems to be an efficient symptomatic treatment for children and adolescents with OI.
  • Is Part Of: Archives of Disease in Childhood, May 2002, Vol.86(5), p.356
  • Identifier: ISSN: 00039888 ; E-ISSN: 14682044 ; DOI: 10.1136/adc.86.5.356
  • Subjects: Osteoporosis ; Teenagers ; Pain ; Analgesics ; Patients ; Collagen ; Growth Hormones ; Genotype & Phenotype ; Pain (Neurology) ; Radiology ; Rheumatology ; Clinical Diagnostic Tests ; Radiology (Diagnostics) ; Trauma ; Injury ; Bisphosphonate ; Osteogenesis Imperfecta
  • Language: English
  • Source: © ProQuest LLC All rights reserved
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