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An association between an aggrecan polymorphic allele and bilateral hand osteoarthritis in elderly white men: data from the Baltimore Longitudinal Study of Aging (BLSA)

Horton, W E ; Lethbridge-Cejku, M ; Hochberg, M C ; Balakir, R ; Precht, P ; Plato, C C ; Tobin, J D ; Meek, L ; Doege, K

Osteoarthritis and cartilage, July 1998, Vol.6(4), pp.245-51 [Peer Reviewed Journal]

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  • Title:
    An association between an aggrecan polymorphic allele and bilateral hand osteoarthritis in elderly white men: data from the Baltimore Longitudinal Study of Aging (BLSA)
  • Author: Horton, W E ; Lethbridge-Cejku, M ; Hochberg, M C ; Balakir, R ; Precht, P ; Plato, C C ; Tobin, J D ; Meek, L ; Doege, K
  • Description: The aggrecan proteoglycan is a major component of articular cartilage and supports the biomechanical function of this tissue. A variable number tandem repeat (VNTR) polymorphism has been discovered recently in a region of the human aggrecan gene that codes for the chondroitin sulfate attachment sites.... DNA was obtained from 93 Caucasian men, aged 60 and above, who had bilateral hand and standing knee radiographs read for changes of OA. The DNA was analyzed by polymerase chain reaction (PCR) and/or Southern blotting for the presence of the VNTR alleles. Bilateral hand OA and knee OA were present in 46 and 30% of the men respectively. The following distribution of alleles was observed: allele 33 (0.5%), 29 (2.2%), 28 (31.7%), 27 (43.0%), 26 (16.7%), 25 (3.2%), 22 (2.2%) and 19 (0.5%). This distribution was similar to that detected in a random population... These data demonstrate the first association between a human aggrecan gene polymorphic allele and hand OA. This finding supports the concept that genetic factors may play a role in the development and/or progression of some forms of age-onset OA.
  • Is Part Of: Osteoarthritis and cartilage, July 1998, Vol.6(4), pp.245-51
  • Identifier: ISSN: 1063-4584 ; PMID: 9876393 Version:1
  • Subjects: Extracellular Matrix Proteins ; Polymorphism, Genetic ; Chondroitin Sulfate Proteoglycans -- Genetics ; Osteoarthritis -- Genetics ; Proteoglycans -- Genetics
  • Language: English
  • Source: MEDLINE/PubMed (U.S. National Library of Medicine)

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