skip to main content
Language:
Search Limited to: Search Limited to: Resource type Show Results with: Show Results with: Index

Chronic renal neuroadrenergic hypertension is associated with increased renal norepinephrine sensitivity and volume contraction

Plato, C F ; Osborn, J L

Hypertension (Dallas, Tex. : 1979), December 1996, Vol.28(6), pp.1034-40 [Peer Reviewed Journal]

Full text available

Citations Cited by
  • Title:
    Chronic renal neuroadrenergic hypertension is associated with increased renal norepinephrine sensitivity and volume contraction
  • Author: Plato, C F ; Osborn, J L
  • Description: Individuals with essential hypertension have been characterized by increased renal sympathetic vascular tone with decreased plasma volume and normal cardiac output compared with normotensive individuals. We used a servo-controlled intrarenal infusion system to evaluate the hemodynamic, renal excretory, and plasma hormonal responses to 28-day, low-level elevations in the intrarenal adrenergic neurotransmitter norepinephrine. In uninephrectomized dogs (n = 6), servo-controlled norepinephrine infusion increased mean arterial pressure from 95.6 +/- 3.1 to 115.7 +/- 4.9 mm Hg on day 1 without concomitant reductions in renal blood flow. Arterial hypertension was sustained and renal vascular resistance increased during the 28 days of servo-controlled norepinephrine infusion despite significant decreases in the daily dose of intrarenal norepinephrine (1.49 +/- 0.23 to 0.47 +/- 0.25 mg/d) necessary to maintain renal blood flow constant. Arterial pressure returned to control values with the cessation...
  • Is Part Of: Hypertension (Dallas, Tex. : 1979), December 1996, Vol.28(6), pp.1034-40
  • Identifier: ISSN: 0194-911X ; PMID: 8952593 Version:1
  • Subjects: Hemodynamics -- Drug Effects ; Hypertension, Renal -- Chemically Induced ; Norepinephrine -- Blood
  • Language: English
  • Source: MEDLINE/PubMed (U.S. National Library of Medicine)

Searching Remote Databases, Please Wait