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Enhanced neutralizing antibody response induced by inactivated enterovirus 71 in cynomolgus monkeys

In, Hyun Ju ; Lim, Heeji ; Lee, Jung-Ah ; Lee, Sang-Rae ; Jin, Yeung Bae ; Jeong, Kang-Jin ; Hyeon, Ji-Yeon ; Yoo, Jung Sik ; Lee, June-Woo ; Choi, Young Ki ; Lee, Sang-Won

PloS one, 2018, Vol.13(10), pp.e0202552 [Peer Reviewed Journal]

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  • Title:
    Enhanced neutralizing antibody response induced by inactivated enterovirus 71 in cynomolgus monkeys
  • Author: In, Hyun Ju ; Lim, Heeji ; Lee, Jung-Ah ; Lee, Sang-Rae ; Jin, Yeung Bae ; Jeong, Kang-Jin ; Hyeon, Ji-Yeon ; Yoo, Jung Sik ; Lee, June-Woo ; Choi, Young Ki ; Lee, Sang-Won
  • Description: Enterovirus 71 (EV71) is a major etiological agent of various public health issues, particularly in the Asia-Pacific region. EV71 causes hand-foot-and-mouth disease (HFMD) and is associated with serious neurological disorders in young children. A formalin-inactivated EV71 candidate vaccine (KCDC-HFMDV1-EV71) based on the C4 subgenotype was previously developed and confirmed to be a potential candidate vaccine for prevention of EV71 infection in mice. In this study, an inactivated EV71 vaccine was used for analysis of long-term immunogenicity and efficacy in cynomolgus monkeys, a common nonhuman primate model. The vaccine was immunized three times at 0, 4, and 8 weeks with either 20-μg doses of EV71 candidate vaccine formulated with aluminum hydroxide gel adjuvant or phosphate-buffered saline as a control. The group immunized with the inactivated EV71 showed significantly increased EV71-specific antibody and serum neutralizing antibody titers at 3 weeks after vaccination and maintained these elevated titers until the end of the experiment (54 weeks after vaccination). The sera from vaccinated cynomolgus monkeys showed a crossreactive neutralizing antibody response to the heterologous subtype of EV71 (B1-4, C1, and C2). These findings suggest that the inactivated EV71 candidate vaccine may be a potential vaccine candidate and valuable tool for the control of HFMD.
  • Is Part Of: PloS one, 2018, Vol.13(10), pp.e0202552
  • Identifier: E-ISSN: 1932-6203 ; PMID: 30278051 Version:1 ; DOI: 10.1371/journal.pone.0202552
  • Subjects: Enterovirus A, Human -- Immunology ; Enterovirus Infections -- Prevention & Control ; Hand, Foot and Mouth Disease -- Prevention & Control ; Vaccines, Inactivated -- Administration & Dosage
  • Language: English

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