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Modulation of Na-K-ATPase activity in the mouse medullary thick ascending limb of Henle. Effects of mineralocorticoids and sodium

Grossman, E B ; Hebert, S C

The Journal of clinical investigation, March 1988, Vol.81(3), pp.885-92 [Peer Reviewed Journal]

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  • Title:
    Modulation of Na-K-ATPase activity in the mouse medullary thick ascending limb of Henle. Effects of mineralocorticoids and sodium
  • Author: Grossman, E B ; Hebert, S C
  • Description: This study investigates the effect of variations in mineralocorticoid as well as cell sodium delivery and uptake on Na-K-ATPase activity in the mouse medullary thick ascending limb of Henle (mTALH). Pharmacologic doses of the mineralocorticoid deoxycorticosterone acetate (DOCA) resulted in a 28% increase of Na-K-ATPase activity. Furosemide-induced inhibition of sodium uptake by the mTALH cell also resulted in Na-K-ATPase activity reduction (45%). Sodium deprivation did not cause a clear change in enzyme activity, either at 3 d or 2 wk, likely reflecting the result of the opposing influences of decreased sodium delivery and increased endogenous aldosterone. Finally, the behavior of Na-K-ATPase activity at 3 d of sodium deprivation in the mTALH contrasted with a 60% increase in activity observed in the cortical collecting tubule, a nephron segment known to be responsive to mineralocorticoid, and this heterogeneity of response may suggest an important role for the mTALH in maintaining salt homeostasis.
  • Is Part Of: The Journal of clinical investigation, March 1988, Vol.81(3), pp.885-92
  • Identifier: ISSN: 0021-9738 ; PMID: 2830316 Version:1
  • Subjects: Desoxycorticosterone -- Pharmacology ; Kidney Tubules -- Enzymology ; Loop of Henle -- Enzymology ; Sodium -- Pharmacology ; Sodium-Potassium-Exchanging Atpase -- Metabolism
  • Language: English
  • Source: MEDLINE/PubMed (U.S. National Library of Medicine)

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