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Potential mechanism of enhanced postprandial glucagon-like peptide-1 release following treatment with a diacylglycerol acyltransferase 1 inhibitor

Liu, Jinqi ; Mclaren, David G ; Chen, Dunlu ; Kan, Yanqing ; Stout, Steven J ; Shen, Xiaolan ; Murphy, Beth Ann ; Forrest, Gail ; Karanam, Bindhu ; Sonatore, Lisa ; He, Shuwen ; Roddy, Thomas P ; Pinto, Shirly

Pharmacology research & perspectives, December 2015, Vol.3(6), pp.e00193 [Peer Reviewed Journal]

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  • Title:
    Potential mechanism of enhanced postprandial glucagon-like peptide-1 release following treatment with a diacylglycerol acyltransferase 1 inhibitor
  • Author: Liu, Jinqi ; Mclaren, David G ; Chen, Dunlu ; Kan, Yanqing ; Stout, Steven J ; Shen, Xiaolan ; Murphy, Beth Ann ; Forrest, Gail ; Karanam, Bindhu ; Sonatore, Lisa ; He, Shuwen ; Roddy, Thomas P ; Pinto, Shirly
  • Description: Studies have demonstrated that blockade of diacylglycerol acyltransferase 1 (DGAT1) leads to prolonged release of glucagon-like peptide 1 (GLP-1) after meal challenge. The current study was undertaken to investigate the mechanism of action underlying the elevated levels of GLP-1 release following pharmacological inhibition of DGAT1. We utilized a potent, specific DGAT1 inhibitor, compound , to investigate the changes in intestinal lipid profile in a mouse model after oral administration of the compound and challenge with tracer containing fatty meal. [C]-oleic acid and LC-MS were employed to trace the fate of dietary fatty acids provided as part of a meal challenge in lean mice. Lipid profiles in plasma, proximal to distal segments of intestine, and feces were evaluated at various times following the meal challenge to study the kinetics of fatty acid absorption, synthesis into complex lipids, and excretion. Pharmacological inhibition of DGAT1 led to reduction of postprandial total and newly...
  • Is Part Of: Pharmacology research & perspectives, December 2015, Vol.3(6), pp.e00193
  • Identifier: ISSN: 2052-1707 ; PMID: 27022467 Version:1
  • Subjects: Dgat1 Inhibitor ; Glp‐1 Release ; Intestine ; Lipid Partition
  • Language: English

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