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C-Kit-Negative Gastrointestinal Stromal Tumor in the Stomach

Seo, Ho Seok ; Hyeon, Ji Yeon ; Shin, Ok-Ran ; Lee, Han Hong

Journal of gastric cancer, December 2015, Vol.15(4), pp.290-4 [Peer Reviewed Journal]

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  • Title:
    C-Kit-Negative Gastrointestinal Stromal Tumor in the Stomach
  • Author: Seo, Ho Seok ; Hyeon, Ji Yeon ; Shin, Ok-Ran ; Lee, Han Hong
  • Description: C-kit-negative gastrointestinal stromal tumors (GISTs) are uncommon, and there have been few reports about the diagnosis and treatment of c-kit-negative GISTs in the stomach. We report the case of a patient who was diagnosed with a huge and atypical GIST in the stomach. The GIST was completely resected and finally diagnosed as c-kit-negative GIST based on immunohistochemical staining of tumor cells, which were negative for CD117 and CD34 and positive for Discovered on GIST-1 (DOG1). C-kit-negative GISTs could be treated by complete resection and/or imatinib, which is the same treatment for c-kit-positive GISTs.
  • Is Part Of: Journal of gastric cancer, December 2015, Vol.15(4), pp.290-4
  • Identifier: ISSN: 2093-582X ; PMID: 26819809 Version:1 ; DOI: 10.5230/jgc.2015.15.4.290
  • Subjects: C-Kit Protein ; Dog1 Protein ; Gastrointestinal Stromal Tumors
  • Language: English
  • Source: MEDLINE/PubMed (U.S. National Library of Medicine)

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