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Incorporation of penicillin-producing fungi into living materials to provide chemically active and antibiotic-releasing surfaces

Gerber, Lukas C ; Koehler, Fabian M ; Grass, Robert N ; Stark, Wendelin J

Angewandte Chemie (International ed. in English), 05 November 2012, Vol.51(45), pp.11293-6 [Peer Reviewed Journal]

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  • Title:
    Incorporation of penicillin-producing fungi into living materials to provide chemically active and antibiotic-releasing surfaces
  • Author: Gerber, Lukas C ; Koehler, Fabian M ; Grass, Robert N ; Stark, Wendelin J
  • Description: Living materials: artificial biological niches are loaded with the penicillin-producing mold Penicillium chrysogenum. This living material consumes food through a nanoporous top layer and releases the antibiotic on-site. No reloading of the active compound is needed. Gram-positive bacteria were efficiently killed if nearby, whereas Gram-negative bacteria (control experiment, not sensitive to penicillin) were not affected.
  • Is Part Of: Angewandte Chemie (International ed. in English), 05 November 2012, Vol.51(45), pp.11293-6
  • Identifier: E-ISSN: 1521-3773 ; PMID: 23044633 Version:1 ; DOI: 10.1002/anie.201204337
  • Subjects: Fungi -- Growth & Development ; Penicillins -- Biosynthesis ; Penicillium -- Metabolism
  • Language: English
  • Source: MEDLINE/PubMed (U.S. National Library of Medicine)

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