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Evidence for the involvement of ZNF804A in cognitive processes of relevance to reading and spelling

Becker, J ; Czamara, D ; Hoffmann, P ; Landerl, K ; Blomert, L ; Brandeis, D ; Vaessen, A ; Maurer, U ; Moll, K ; Ludwig, K U ; Müller-Myhsok, B ; Nöthen, M M ; Schulte-Körne, G ; Schumacher, J

Translational psychiatry, 10 July 2012, Vol.2, pp.e136 [Peer Reviewed Journal]

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  • Title:
    Evidence for the involvement of ZNF804A in cognitive processes of relevance to reading and spelling
  • Author: Becker, J ; Czamara, D ; Hoffmann, P ; Landerl, K ; Blomert, L ; Brandeis, D ; Vaessen, A ; Maurer, U ; Moll, K ; Ludwig, K U ; Müller-Myhsok, B ; Nöthen, M M ; Schulte-Körne, G ; Schumacher, J
  • Description: Previous studies have shown that individuals with schizophrenia and dyslexia display common neurocognitive abnormalities. The aim of the present study was to determine whether known schizophrenia-risk genes contribute to dyslexia risk or to disease-relevant cognitive functions. For this purpose, we genotyped the schizophrenia-associated risk variants within zinc-finger protein 804A (ZNF804A), transcription-factor 4 and neurogranin in a large dyslexia case-control sample. We tested all variants for association with dyslexia (927 cases, 1096 controls), and with eight language-relevant cognitive processes (1552 individuals). We observed six significant associations between language-relevant traits and the ZNF804A-variant rs1344706. Interestingly, the ZNF804A schizophrenia risk variant was associated with a better cognitive performance in our data set. This finding might be consistent with a previously reported ZNF804A association in schizophrenia, in which patients carrying the schizophrenia-risk allele at rs1344706 showed a better performance in two memory tests. In conclusion, the present study provides evidence that ZNF804A might have a role in cognitive traits of relevance to reading and spelling, and underlines the phenotypic complexity that might be associated with ZNF804A.
  • Is Part Of: Translational psychiatry, 10 July 2012, Vol.2, pp.e136
  • Identifier: E-ISSN: 2158-3188 ; PMID: 22781169 Version:1 ; DOI: 10.1038/tp.2012.62
  • Subjects: Language ; Dyslexia -- Genetics ; Genetic Variation -- Physiology ; Kruppel-Like Transcription Factors -- Genetics ; Neurogranin -- Genetics ; Schizophrenia -- Genetics
  • Language: English
  • Source: MEDLINE/PubMed (U.S. National Library of Medicine)

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