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Weight gain associated with olanzapine and risperidone in adolescent patients: a comparative prospective study

Ratzoni, Gidi ; Gothelf, Doron ; Brand-Gothelf, Ayelet ; Reidman, Judith ; Kikinzon, Leonid ; Gal, Gilad ; Phillip, Moshe ; Apter, Alan ; Weizman, Ronit

Journal of the American Academy of Child and Adolescent Psychiatry, March 2002, Vol.41(3), pp.337-43 [Peer Reviewed Journal]

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  • Title:
    Weight gain associated with olanzapine and risperidone in adolescent patients: a comparative prospective study
  • Author: Ratzoni, Gidi ; Gothelf, Doron ; Brand-Gothelf, Ayelet ; Reidman, Judith ; Kikinzon, Leonid ; Gal, Gilad ; Phillip, Moshe ; Apter, Alan ; Weizman, Ronit
  • Description: To evaluate weight gain associated with olanzapine, risperidone, and haloperidol treatment and its clinical risk factors in adolescent patients. The study was conducted at three adolescent psychiatric departments in two mental health centers in the Tel Aviv area. All patients were Jewish Israelis. Weight and body mass index (BMI) of hospitalized adolescents treated with olanzapine (n = 21), risperidone (n = 21), or haloperidol (n = 8) were prospectively monitored on a weekly basis for the first 12 weeks of treatment. Various clinical risk factors were tested for association with weight gain. The olanzapine and risperidone groups experienced significant weight gain between baseline and endpoint (p 7%) was recorded in 19 patients (90.5%), 9 patients (42.9%), and 1 (12.5%) patient, respectively Gender (males), low concern about gaining weight (females), low baseline BMI, and paternal BMI were positively correlated with weight gain, whereas previous neuroleptic history, neuroleptic dosage, response to treatment, and illness duration were not. Olanzapine and risperidone are associated with extreme weight gain in adolescents, much higher than that reported in adults. This side effect should be taken into consideration before prescribing these medications, especially in patients at high risk.
  • Is Part Of: Journal of the American Academy of Child and Adolescent Psychiatry, March 2002, Vol.41(3), pp.337-43
  • Identifier: ISSN: 0890-8567 ; PMID: 11886029 Version:1
  • Subjects: Weight Gain ; Antipsychotic Agents -- Therapeutic Use ; Haloperidol -- Therapeutic Use ; Mental Disorders -- Drug Therapy ; Pirenzepine -- Analogs & Derivatives ; Risperidone -- Therapeutic Use
  • Language: English
  • Source: MEDLINE/PubMed (U.S. National Library of Medicine)

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