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High CXCR4 and low VLA-4 expression predicts poor survival in adults with acute lymphoblastic leukemia

Ko, Sun-Young ; Park, Chan-Jeoung ; Park, Sang-Hyuk ; Cho, Young-Uk ; Jang, Seongsoo ; Seo, Eul-Ju ; Kim, Nayoung ; Kim, Dae-Young ; Koh, Kyung Nam ; Im, Ho Joon ; Seo, Jong-Jin ; Chi, Hyun-Sook

Leukemia Research, January 2014, Vol.38(1), pp.65-70 [Peer Reviewed Journal]

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  • Title:
    High CXCR4 and low VLA-4 expression predicts poor survival in adults with acute lymphoblastic leukemia
  • Author: Ko, Sun-Young ; Park, Chan-Jeoung ; Park, Sang-Hyuk ; Cho, Young-Uk ; Jang, Seongsoo ; Seo, Eul-Ju ; Kim, Nayoung ; Kim, Dae-Young ; Koh, Kyung Nam ; Im, Ho Joon ; Seo, Jong-Jin ; Chi, Hyun-Sook
  • Description: Data regarding the prognostic significance of CXCR4 and VLA-4 in ALL are limited. Especially, VLA-4 has not been evaluated at the time of diagnosis in both adult and childhood ALL patients. We prospectively analyzed the expression of VLA-4 and CXCR4 in 54 patients (VLA-4 in 29 adults and 25 children and CXCR4 in 22 adults and 24 children) newly diagnosed with ALL by flow cytometry. Expression levels of VLA-4 and CXCR4 were not different between adults and children with ALL. High CXCR4 and low VLA-4 expression each correlated with worse prognosis in adults; patients with high CXCR4 expression had shorter disease-free survival ( = 0.01) and overall survival ( = 0.04) and patients with low VLA-4 expression had shorter disease-free survival ( = 0.02). Expression levels of CXCR4 and VLA-4 did not predict patient prognosis in children. Analysis of CXCR4 and VLA-4 expression at diagnosis in adults with ALL can provide useful information on patient prognosis.
  • Is Part Of: Leukemia Research, January 2014, Vol.38(1), pp.65-70
  • Identifier: ISSN: 0145-2126 ; E-ISSN: 1873-5835 ; DOI: 10.1016/j.leukres.2013.10.016
  • Subjects: Vla-4 ; Cxcr4 ; Acute Lymphoblastic Leukemia ; Adult ; Survival ; Prognostic Marker ; Medicine
  • Language: English
  • Source: ScienceDirect Journals (Elsevier)

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