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P296 Spike timing dependent plasticity in the human parietal-prefrontal network

Casula, E.P ; Pellicciari, M.C ; Picazio, S ; Caltagirone, C ; Koch, G

Clinical Neurophysiology, March 2017, Vol.128(3), pp.e155-e156 [Peer Reviewed Journal]

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  • Title:
    P296 Spike timing dependent plasticity in the human parietal-prefrontal network
  • Author: Casula, E.P ; Pellicciari, M.C ; Picazio, S ; Caltagirone, C ; Koch, G
  • Description: Learning may occur through associative changes in the synaptic strength of neural connections that can be induced by coupling of activity of interconnected neurons with precise timing (spike-timing dependent plasticity, STDP). It is debated if this model can be applied in the context of large-scale cortical networks in humans. We combined transcranial magnetic stimulation with concurrent electroencephalography to directly investigate if precise repeated activation of pre and post-synaptic large-scale cortical inputs produces STDP effects within the parietal-prefrontal network of 15 healthy volunteers. We found direct evidence for bidirectional STDP after effects over the DLPFC ruled by the PPC pre-synaptic inputs. Specifically, when the pre-synaptic input (PPC) precedes repeatedly the post-synaptic activation (DLPFC) by 10ms a LTD-like effect of TMS-evoked activity is induced within the DLPFC. When the temporal order of the two stimulated...
  • Is Part Of: Clinical Neurophysiology, March 2017, Vol.128(3), pp.e155-e156
  • Identifier: ISSN: 1388-2457 ; E-ISSN: 1872-8952 ; DOI: 10.1016/j.clinph.2016.10.404
  • Subjects: Medicine
  • Language: English

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