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ID 403 – Fronto-parietal changes in oscillatory activity reflects spike-timing-dependent plasticity

Casula, E.P ; Pellicciari, M.C ; Picazio, S ; Koch, G

Clinical Neurophysiology, March 2016, Vol.127(3), pp.e69-e69 [Peer Reviewed Journal]

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  • Title:
    ID 403 – Fronto-parietal changes in oscillatory activity reflects spike-timing-dependent plasticity
  • Author: Casula, E.P ; Pellicciari, M.C ; Picazio, S ; Koch, G
  • Description: We applied cortico-cortical PAS to induce spike-timing-dependent-plasticity in a fronto-parietal network. Plasticity dynamics were investigated by means of concurrent TMS and hd-EEG. 8 healthy volunteers underwent two experimental sessions during which they received a fronto-parietal (FP) or a parieto-frontal (PF) PAS (ISIms, 0.2Hz, 100pulses). PAS effects were investigated in the oscillatory (ERSP) and in the time domain (LMFP) over DLPFC, PPC and M1 (as a control area) with 80 neuronavigated TMS single-pulses applied before and after the PAS protocol. EEG was recorded throughout the stimulation from 64 channels all over the scalp. Beta oscillations evoked by TMS of DLPFC were differently modulated by the two PAS protocols: FP-PAS produced a desynchronization, whereas PF-PAS produced a strong synchronization of beta activity compared to baseline values. FP-PAS resulted also in an increase of DLPFC reactivity, as assessed by TEPs waveform...
  • Is Part Of: Clinical Neurophysiology, March 2016, Vol.127(3), pp.e69-e69
  • Identifier: ISSN: 1388-2457 ; E-ISSN: 1872-8952 ; DOI: 10.1016/j.clinph.2015.11.230
  • Subjects: Medicine
  • Language: English

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